Septerna (SEPN) Competitors $11.40 +0.80 (+7.55%) Closing price 07/2/2025 04:00 PM EasternExtended Trading$11.44 +0.04 (+0.35%) As of 04:31 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOwnershipSEC FilingsTrendsBuy This Stock SEPN vs. HRMY, IRON, TARS, BEAM, CNTA, ARQT, ADPT, IMCR, SPRY, and EWTXShould you be buying Septerna stock or one of its competitors? The main competitors of Septerna include Harmony Biosciences (HRMY), Disc Medicine (IRON), Tarsus Pharmaceuticals (TARS), Beam Therapeutics (BEAM), Centessa Pharmaceuticals (CNTA), Arcutis Biotherapeutics (ARQT), Adaptive Biotechnologies (ADPT), Immunocore (IMCR), ARS Pharmaceuticals (SPRY), and Edgewise Therapeutics (EWTX). These companies are all part of the "pharmaceutical products" industry. Septerna vs. Its Competitors Harmony Biosciences Disc Medicine Tarsus Pharmaceuticals Beam Therapeutics Centessa Pharmaceuticals Arcutis Biotherapeutics Adaptive Biotechnologies Immunocore ARS Pharmaceuticals Edgewise Therapeutics Septerna (NASDAQ:SEPN) and Harmony Biosciences (NASDAQ:HRMY) are both small-cap medical companies, but which is the superior investment? We will contrast the two companies based on the strength of their media sentiment, valuation, dividends, profitability, risk, earnings, analyst recommendations and institutional ownership. Is SEPN or HRMY more profitable? Harmony Biosciences has a net margin of 20.53% compared to Septerna's net margin of 0.00%. Harmony Biosciences' return on equity of 24.32% beat Septerna's return on equity.Company Net Margins Return on Equity Return on Assets SepternaN/A N/A N/A Harmony Biosciences 20.53%24.32%15.92% Do analysts recommend SEPN or HRMY? Septerna presently has a consensus price target of $26.75, suggesting a potential upside of 134.65%. Harmony Biosciences has a consensus price target of $53.63, suggesting a potential upside of 67.00%. Given Septerna's higher possible upside, equities research analysts plainly believe Septerna is more favorable than Harmony Biosciences.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Septerna 0 Sell rating(s) 1 Hold rating(s) 4 Buy rating(s) 0 Strong Buy rating(s) 2.80Harmony Biosciences 0 Sell rating(s) 0 Hold rating(s) 7 Buy rating(s) 1 Strong Buy rating(s) 3.13 Do insiders and institutionals hold more shares of SEPN or HRMY? 86.2% of Harmony Biosciences shares are owned by institutional investors. 4.3% of Septerna shares are owned by insiders. Comparatively, 23.6% of Harmony Biosciences shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth. Does the media refer more to SEPN or HRMY? In the previous week, Septerna had 2 more articles in the media than Harmony Biosciences. MarketBeat recorded 2 mentions for Septerna and 0 mentions for Harmony Biosciences. Harmony Biosciences' average media sentiment score of 1.90 beat Septerna's score of 1.20 indicating that Harmony Biosciences is being referred to more favorably in the news media. Company Overall Sentiment Septerna Positive Harmony Biosciences Very Positive Which has better earnings & valuation, SEPN or HRMY? Harmony Biosciences has higher revenue and earnings than Septerna. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioSepterna$1.08M470.36-$71.80MN/AN/AHarmony Biosciences$714.73M2.58$145.49M$2.6212.26 SummaryHarmony Biosciences beats Septerna on 11 of the 14 factors compared between the two stocks. Get Septerna News Delivered to You Automatically Sign up to receive the latest news and ratings for SEPN and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding SEPN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart SEPN vs. The Competition Export to ExcelMetricSepternaMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$472.32M$2.88B$5.54B$8.87BDividend YieldN/A2.64%5.39%4.10%P/E RatioN/A21.3126.1719.90Price / Sales470.36278.47413.55113.66Price / CashN/A41.4736.1356.90Price / Book1.217.518.025.38Net Income-$71.80M-$55.05M$3.15B$248.50M7 Day Performance4.88%2.07%1.48%2.06%1 Month Performance14.34%4.84%3.66%4.86%1 Year PerformanceN/A5.37%34.68%20.24% Septerna Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)SEPNSepterna1.7138 of 5 stars$11.40+7.5%$26.75+134.6%N/A$472.32M$1.08M0.00N/APositive NewsHRMYHarmony Biosciences4.8291 of 5 stars$31.93+0.1%$53.63+67.9%+7.0%$1.83B$714.73M12.19200Positive NewsIRONDisc Medicine2.0118 of 5 stars$51.68+0.1%$96.70+87.1%+27.8%$1.79BN/A-13.1830Positive NewsTARSTarsus Pharmaceuticals2.2687 of 5 stars$40.60-0.1%$66.67+64.2%+46.8%$1.71B$182.95M-14.8750BEAMBeam Therapeutics1.9127 of 5 stars$16.71-0.3%$48.75+191.7%-11.9%$1.69B$63.52M-3.62510CNTACentessa Pharmaceuticals2.9685 of 5 stars$13.00+4.6%$27.89+114.5%+56.7%$1.66B$6.85M-7.18200ARQTArcutis Biotherapeutics2.0541 of 5 stars$14.40+4.2%$18.80+30.6%+48.0%$1.65B$212.82M-13.85150Positive NewsADPTAdaptive Biotechnologies3.4624 of 5 stars$10.56+1.7%$10.57+0.1%+240.7%$1.58B$178.96M-11.00790News CoverageIMCRImmunocore2.5011 of 5 stars$31.12-0.7%$58.89+89.2%-5.9%$1.56B$333.58M-72.37320SPRYARS Pharmaceuticals2.9444 of 5 stars$16.57+4.9%$31.00+87.1%+93.4%$1.55B$89.15M-103.5690Insider TradeEWTXEdgewise Therapeutics2.6574 of 5 stars$14.18-0.8%$39.78+180.5%-29.2%$1.50BN/A-9.1560News CoverageAnalyst ForecastAnalyst Revision Related Companies and Tools Related Companies HRMY Competitors IRON Competitors TARS Competitors BEAM Competitors CNTA Competitors ARQT Competitors ADPT Competitors IMCR Competitors SPRY Competitors EWTX Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:SEPN) was last updated on 7/3/2025 by MarketBeat.com Staff From Our PartnersHere's the last trade you should make before heading out for the weekend tomorrow.Make this one trade at 2:59 PM on Friday afternoon, and you'll thank me on Monday morning.Timothy Sykes | SponsoredThis Signal Only Flashes Once Every 4 Years – And It Just TriggeredThis same signal has appeared twice before in the past 8 years — both times, it kicked off major moves in cryp...Crypto Swap Profits | SponsoredTrump’s New Order Could Boost Social Security Benefits by 400%If you collect—or plan to collect—Social Security, you need to see this. 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