Spruce Biosciences (SPRB) Competitors $9.46 -0.34 (-3.46%) As of 01:54 PM Eastern This is a fair market value price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock SPRB vs. AYTU, LEXX, SONN, LSTA, MTEX, EDSA, HOTH, LSB, ABP, and SYBXShould you be buying Spruce Biosciences stock or one of its competitors? The main competitors of Spruce Biosciences include Aytu BioPharma (AYTU), Lexaria Bioscience (LEXX), Sonnet BioTherapeutics (SONN), Lisata Therapeutics (LSTA), Mannatech (MTEX), Edesa Biotech (EDSA), Hoth Therapeutics (HOTH), LakeShore Biopharma (LSB), Abpro (ABP), and Synlogic (SYBX). These companies are all part of the "pharmaceutical products" industry. Spruce Biosciences vs. Its Competitors Aytu BioPharma Lexaria Bioscience Sonnet BioTherapeutics Lisata Therapeutics Mannatech Edesa Biotech Hoth Therapeutics LakeShore Biopharma Abpro Synlogic Spruce Biosciences (NASDAQ:SPRB) and Aytu BioPharma (NASDAQ:AYTU) are both small-cap medical companies, but which is the better business? We will compare the two companies based on the strength of their dividends, analyst recommendations, risk, media sentiment, profitability, institutional ownership, valuation and earnings. Does the media favor SPRB or AYTU? In the previous week, Spruce Biosciences and Spruce Biosciences both had 1 articles in the media. Aytu BioPharma's average media sentiment score of 1.91 beat Spruce Biosciences' score of 0.00 indicating that Aytu BioPharma is being referred to more favorably in the news media. Company Overall Sentiment Spruce Biosciences Neutral Aytu BioPharma Very Positive Do analysts prefer SPRB or AYTU? Spruce Biosciences currently has a consensus target price of $131.25, suggesting a potential upside of 1,287.27%. Aytu BioPharma has a consensus target price of $10.00, suggesting a potential upside of 331.97%. Given Spruce Biosciences' higher possible upside, equities analysts clearly believe Spruce Biosciences is more favorable than Aytu BioPharma.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Spruce Biosciences 0 Sell rating(s) 6 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 2.00Aytu BioPharma 0 Sell rating(s) 0 Hold rating(s) 2 Buy rating(s) 0 Strong Buy rating(s) 3.00 Do institutionals and insiders hold more shares of SPRB or AYTU? 91.7% of Spruce Biosciences shares are owned by institutional investors. Comparatively, 33.5% of Aytu BioPharma shares are owned by institutional investors. 6.9% of Spruce Biosciences shares are owned by company insiders. Comparatively, 3.6% of Aytu BioPharma shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term. Which has higher earnings & valuation, SPRB or AYTU? Aytu BioPharma has higher revenue and earnings than Spruce Biosciences. Aytu BioPharma is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioSpruce Biosciences$4.91M1.08-$47.92M-$86.21-0.11Aytu BioPharma$81M0.26-$15.84M-$0.72-3.22 Which has more risk & volatility, SPRB or AYTU? Spruce Biosciences has a beta of 2.43, suggesting that its share price is 143% more volatile than the S&P 500. Comparatively, Aytu BioPharma has a beta of 0.22, suggesting that its share price is 78% less volatile than the S&P 500. Is SPRB or AYTU more profitable? Aytu BioPharma has a net margin of 2.37% compared to Spruce Biosciences' net margin of -555.23%. Aytu BioPharma's return on equity of 3.51% beat Spruce Biosciences' return on equity.Company Net Margins Return on Equity Return on Assets Spruce Biosciences-555.23% -62.10% -47.49% Aytu BioPharma 2.37%3.51%0.91% SummaryAytu BioPharma beats Spruce Biosciences on 10 of the 15 factors compared between the two stocks. Get Spruce Biosciences News Delivered to You Automatically Sign up to receive the latest news and ratings for SPRB and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding SPRB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart SPRB vs. The Competition Export to ExcelMetricSpruce BiosciencesPharmaceutical IndustryMedical SectorNASDAQ ExchangeMarket Cap$5.32M$840.59M$5.72B$10.27BDividend YieldN/A4.84%5.72%4.60%P/E Ratio-10.061.1975.6826.46Price / Sales1.0826.63493.40165.76Price / CashN/A19.5625.8129.90Price / Book5.036.6612.836.31Net Income-$47.92M-$4.13M$3.29B$270.30M7 Day Performance5.12%2.46%0.32%2.03%1 Month Performance5.01%7.96%4.71%6.23%1 Year Performance-72.34%23.60%68.73%28.08% Spruce Biosciences Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)SPRBSpruce Biosciences1.1138 of 5 stars$9.46-3.5%$131.25+1,287.3%-71.9%$5.32M$4.91M-10.0620News CoverageAYTUAytu BioPharma4.0307 of 5 stars$2.27+0.9%$10.00+340.5%-9.7%$20.20M$81M-3.15160LEXXLexaria Bioscience3.8876 of 5 stars$1.04+1.0%$4.00+284.6%-62.1%$20.15M$460K-1.557Negative NewsShort Interest ↓SONNSonnet BioTherapeutics2.8735 of 5 stars$3.29+15.4%$20.00+507.9%-14.6%$19.46M$20K0.0010Positive NewsGap UpLSTALisata Therapeutics3.2557 of 5 stars$2.18+0.5%$23.50+978.0%-27.1%$19M$1M-0.9830Short Interest ↓Gap DownMTEXMannatech0.9766 of 5 stars$9.37-2.1%N/A+8.1%$18.19M$117.87M-4.59250Short Interest ↓Gap DownHigh Trading VolumeEDSAEdesa Biotech1.4516 of 5 stars$2.42-4.3%$5.00+106.6%-43.6%$17.81MN/A-1.8320Gap UpHOTHHoth Therapeutics2.8359 of 5 stars$1.47+10.5%$4.00+172.1%+65.5%$17.64MN/A-1.374Analyst UpgradeShort Interest ↓LSBLakeShore Biopharma1.2302 of 5 stars$0.83-0.7%N/A-86.6%$17.44M$85.67M0.00773Short Interest ↓Gap UpABPAbpro3.7551 of 5 stars$0.22+1.2%$4.00+1,739.1%N/A$17.24M$183K0.0015Positive NewsGap DownSYBXSynlogic1.64 of 5 stars$1.47+0.7%N/A+17.5%$17.08M$10K-18.3880Positive NewsShort Interest ↓Gap Up Related Companies and Tools Related Companies Aytu BioPharma Competitors Lexaria Bioscience Competitors Sonnet BioTherapeutics Competitors Lisata Therapeutics Competitors Mannatech Competitors Edesa Biotech Competitors Hoth Therapeutics Competitors LakeShore Biopharma Competitors Abpro Competitors Synlogic Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:SPRB) was last updated on 9/16/2025 by MarketBeat.com Staff From Our PartnersNew Biotech Backed by Proven Incubator Now Open to PublicA successful biotech incubator just opened its next chapter - and you're invited to their raise. This deal ...i2i Marketing Group, LLC | SponsoredSean Hannity: Help Protect Your RetirementThis Guide to retirement protection has helped thousands protect over $3 billion dollars in retirement savings...Goldco Precious Metals | SponsoredWhat a Former CIA Agent Knows About the Coming Collapse This isn’t just another gold investing book—it’s a survival playbook written by a former CIA officer trained...Advantage Gold | SponsoredForget NVDA. Put $1,000 into this stock nowA massive money shift is underway in the AI market. And it's opening up an extraordinary opportunity in a NEW ...Chaikin Analytics | SponsoredREVEALED: Something Big Happening Behind White House Doorswhat I just learned about what’s unfolding in the White House is truly stunning… And you need to see it for...Paradigm Press | SponsoredTrump’s Plan May Undo 1933’s Biggest Financial InjusticeTrump's Reset Can Give Birth To America's Greatest Era Yet A 90-Year cycle may end soon, creating real weal...American Hartford Gold | SponsoredCrypto Gets Official Government Backing—Here's the WinnerTrump Just Signed the GENIUS Act—One Coin is About to Explode We're at the BEGINNING of smart money really ...Crypto 101 Media | SponsoredMarket Panic: Trump Just Dropped a Bomb on Your Stockstock Market Panic: Trump Just Dropped a Bomb on Your Stocks The market is in freefall—and Trump's new tarif...American Alternative | Sponsored Adding Choose a watchlist: Watchlist Adding You have already added ten stocks to your watchlist. Upgrade to MarketBeat All Access to add more stocks to your watchlist. Adding Spruce Biosciences, Inc. Please log in to your account or sign up in order to add this asset to your watchlist. Share Spruce Biosciences With A Colleague Link copied to clipboard. Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. Real-time analyst ratings, insider transactions, earnings data, and more. Our daily ratings and market update email newsletter. Sign in to your free account to enjoy all that MarketBeat has to offer. Sign In Create Account Your Email Address: Email Address Required Your Password: Password Required Log In or Sign in with Facebook Sign in with Google Forgot your password? Your Email Address: Please enter your email address. Please enter a valid email address Choose a Password: Please enter your password. Your password must be at least 8 characters long and contain at least 1 number, 1 letter, and 1 special character. Create My Account (Free) or Sign in with Facebook Sign in with Google By creating a free account, you agree to our terms of service. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Free SPRB Stock Alerts