Spruce Biosciences (SPRB) Competitors $12.40 +3.60 (+40.91%) As of 09/12/2025 03:58 PM Eastern Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock SPRB vs. AYTU, LEXX, SONN, LSTA, MTEX, EDSA, HOTH, LSB, ABP, and SYBXShould you be buying Spruce Biosciences stock or one of its competitors? The main competitors of Spruce Biosciences include Aytu BioPharma (AYTU), Lexaria Bioscience (LEXX), Sonnet BioTherapeutics (SONN), Lisata Therapeutics (LSTA), Mannatech (MTEX), Edesa Biotech (EDSA), Hoth Therapeutics (HOTH), LakeShore Biopharma (LSB), Abpro (ABP), and Synlogic (SYBX). These companies are all part of the "pharmaceutical products" industry. Spruce Biosciences vs. Its Competitors Aytu BioPharma Lexaria Bioscience Sonnet BioTherapeutics Lisata Therapeutics Mannatech Edesa Biotech Hoth Therapeutics LakeShore Biopharma Abpro Synlogic Aytu BioPharma (NASDAQ:AYTU) and Spruce Biosciences (NASDAQ:SPRB) are both small-cap medical companies, but which is the superior business? We will compare the two businesses based on the strength of their dividends, institutional ownership, profitability, valuation, analyst recommendations, media sentiment, risk and earnings. Do institutionals & insiders hold more shares of AYTU or SPRB? 33.5% of Aytu BioPharma shares are held by institutional investors. Comparatively, 91.7% of Spruce Biosciences shares are held by institutional investors. 3.6% of Aytu BioPharma shares are held by company insiders. Comparatively, 6.9% of Spruce Biosciences shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth. Do analysts recommend AYTU or SPRB? Aytu BioPharma currently has a consensus price target of $10.00, suggesting a potential upside of 323.73%. Spruce Biosciences has a consensus price target of $131.25, suggesting a potential upside of 958.47%. Given Spruce Biosciences' higher probable upside, analysts clearly believe Spruce Biosciences is more favorable than Aytu BioPharma.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Aytu BioPharma 0 Sell rating(s) 0 Hold rating(s) 2 Buy rating(s) 0 Strong Buy rating(s) 3.00Spruce Biosciences 0 Sell rating(s) 6 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 2.00 Which has better valuation and earnings, AYTU or SPRB? Aytu BioPharma has higher revenue and earnings than Spruce Biosciences. Aytu BioPharma is trading at a lower price-to-earnings ratio than Spruce Biosciences, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioAytu BioPharma$81M0.26-$15.84M-$0.72-3.28Spruce Biosciences$4.91M1.42-$47.92M-$86.21-0.14 Is AYTU or SPRB more profitable? Aytu BioPharma has a net margin of 2.37% compared to Spruce Biosciences' net margin of -555.23%. Aytu BioPharma's return on equity of 3.51% beat Spruce Biosciences' return on equity.Company Net Margins Return on Equity Return on Assets Aytu BioPharma2.37% 3.51% 0.91% Spruce Biosciences -555.23%-62.10%-47.49% Which has more risk & volatility, AYTU or SPRB? Aytu BioPharma has a beta of 0.22, suggesting that its share price is 78% less volatile than the S&P 500. Comparatively, Spruce Biosciences has a beta of 2.43, suggesting that its share price is 143% more volatile than the S&P 500. Does the media refer more to AYTU or SPRB? In the previous week, Aytu BioPharma had 1 more articles in the media than Spruce Biosciences. MarketBeat recorded 1 mentions for Aytu BioPharma and 0 mentions for Spruce Biosciences. Aytu BioPharma's average media sentiment score of 1.91 beat Spruce Biosciences' score of 0.00 indicating that Aytu BioPharma is being referred to more favorably in the media. Company Overall Sentiment Aytu BioPharma Very Positive Spruce Biosciences Neutral SummaryAytu BioPharma beats Spruce Biosciences on 11 of the 16 factors compared between the two stocks. Get Spruce Biosciences News Delivered to You Automatically Sign up to receive the latest news and ratings for SPRB and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding SPRB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart SPRB vs. The Competition Export to ExcelMetricSpruce BiosciencesPharmaceutical IndustryMedical SectorNASDAQ ExchangeMarket Cap$6.97M$934.71M$5.86B$10.14BDividend YieldN/A4.84%5.68%4.59%P/E Ratio-13.191.1074.5225.93Price / Sales1.4226.70547.62126.81Price / CashN/A19.5637.5660.44Price / Book6.606.6912.166.29Net Income-$47.92M-$4.50M$3.28B$270.77M7 Day Performance37.78%8.75%0.87%3.88%1 Month Performance37.78%9.50%4.96%4.88%1 Year Performance-64.47%22.47%60.75%26.01% Spruce Biosciences Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)SPRBSpruce Biosciences1.8567 of 5 stars$12.40+40.9%$131.25+958.5%-63.9%$6.97M$4.91M-13.1920Gap DownHigh Trading VolumeAYTUAytu BioPharma3.9506 of 5 stars$2.27+0.9%$10.00+340.5%-6.3%$20.20M$81M-3.15160Positive NewsShort Interest ↓LEXXLexaria Bioscience3.8814 of 5 stars$1.04+1.0%$4.00+284.6%-66.2%$20.15M$460K-1.557Positive NewsShort Interest ↓SONNSonnet BioTherapeutics2.8673 of 5 stars$3.29+15.4%$20.00+507.9%-7.9%$19.46M$20K0.0010Positive NewsGap UpLSTALisata Therapeutics3.2398 of 5 stars$2.18+0.5%$23.50+978.0%-27.2%$19M$1M-0.9830Short Interest ↓Gap DownMTEXMannatech1.1737 of 5 stars$9.37-2.1%N/A+7.9%$18.19M$117.87M-4.59250News CoveragePositive NewsShort Interest ↓Gap DownHigh Trading VolumeEDSAEdesa Biotech1.4391 of 5 stars$2.42-4.3%$5.00+106.6%-44.5%$17.81MN/A-1.8320Positive NewsGap UpHOTHHoth Therapeutics2.8323 of 5 stars$1.47+10.5%$4.00+172.1%+41.6%$17.64MN/A-1.374Short Interest ↓Gap UpLSBLakeShore Biopharma1.2641 of 5 stars$0.83-0.7%N/A-84.1%$17.44M$85.67M0.00773News CoverageShort Interest ↓Gap UpABPAbpro3.9542 of 5 stars$0.22+1.2%$4.00+1,739.1%N/A$17.24M$183K0.0015Positive NewsSYBXSynlogic1.6397 of 5 stars$1.47+0.7%N/A+12.4%$17.08M$10K-18.3880Positive NewsShort Interest ↓ Related Companies and Tools Related Companies Aytu BioPharma Competitors Lexaria Bioscience Competitors Sonnet BioTherapeutics Competitors Lisata Therapeutics Competitors Mannatech Competitors Edesa Biotech Competitors Hoth Therapeutics Competitors LakeShore Biopharma Competitors Abpro Competitors Synlogic Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:SPRB) was last updated on 9/13/2025 by MarketBeat.com Staff From Our PartnersWhy Trump’s “Smart Dollar” could rewrite the rulesMUST SEE: Donald Trump's Radical Overhaul of the U.S. Dollar Congress just approved President Trump's lates...Stansberry Research | SponsoredTrump's Law S.1582: $21T Dollar Revolution ComingDo you have money in any of these banks? 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