Talphera (TLPH) Competitors $0.49 +0.01 (+1.21%) Closing price 08/22/2025 04:00 PM EasternExtended Trading$0.48 -0.01 (-2.78%) As of 08/22/2025 07:57 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock TLPH vs. ITRM, SCYX, CLSD, RANI, EQ, AKTX, ALXO, ESLA, TPST, and CLNNShould you be buying Talphera stock or one of its competitors? The main competitors of Talphera include Iterum Therapeutics (ITRM), SCYNEXIS (SCYX), Clearside Biomedical (CLSD), Rani Therapeutics (RANI), Equillium (EQ), Akari Therapeutics (AKTX), ALX Oncology (ALXO), Estrella Immunopharma (ESLA), Tempest Therapeutics (TPST), and Clene (CLNN). These companies are all part of the "pharmaceutical products" industry. Talphera vs. Its Competitors Iterum Therapeutics SCYNEXIS Clearside Biomedical Rani Therapeutics Equillium Akari Therapeutics ALX Oncology Estrella Immunopharma Tempest Therapeutics Clene Talphera (NASDAQ:TLPH) and Iterum Therapeutics (NASDAQ:ITRM) are both small-cap medical companies, but which is the superior business? We will compare the two businesses based on the strength of their risk, valuation, profitability, media sentiment, analyst recommendations, earnings, institutional ownership and dividends. Do institutionals & insiders hold more shares of TLPH or ITRM? 37.7% of Talphera shares are owned by institutional investors. Comparatively, 9.2% of Iterum Therapeutics shares are owned by institutional investors. 3.2% of Talphera shares are owned by company insiders. Comparatively, 2.4% of Iterum Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth. Do analysts prefer TLPH or ITRM? Talphera currently has a consensus target price of $5.00, suggesting a potential upside of 914.82%. Iterum Therapeutics has a consensus target price of $9.00, suggesting a potential upside of 1,109.68%. Given Iterum Therapeutics' higher possible upside, analysts clearly believe Iterum Therapeutics is more favorable than Talphera.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Talphera 0 Sell rating(s) 0 Hold rating(s) 2 Buy rating(s) 2 Strong Buy rating(s) 3.50Iterum Therapeutics 0 Sell rating(s) 0 Hold rating(s) 1 Buy rating(s) 0 Strong Buy rating(s) 3.00 Which has higher valuation & earnings, TLPH or ITRM? Talphera has higher revenue and earnings than Iterum Therapeutics. Talphera is trading at a lower price-to-earnings ratio than Iterum Therapeutics, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioTalphera$650K15.55-$13M-$0.40-1.23Iterum TherapeuticsN/AN/A-$24.77M-$0.85-0.88 Which has more volatility & risk, TLPH or ITRM? Talphera has a beta of -0.09, meaning that its stock price is 109% less volatile than the S&P 500. Comparatively, Iterum Therapeutics has a beta of 2.85, meaning that its stock price is 185% more volatile than the S&P 500. Is TLPH or ITRM more profitable? Iterum Therapeutics' return on equity of 0.00% beat Talphera's return on equity.Company Net Margins Return on Equity Return on Assets TalpheraN/A -152.38% -64.32% Iterum Therapeutics N/A N/A -65.01% Does the media favor TLPH or ITRM? In the previous week, Iterum Therapeutics had 1 more articles in the media than Talphera. MarketBeat recorded 3 mentions for Iterum Therapeutics and 2 mentions for Talphera. Talphera's average media sentiment score of 0.20 beat Iterum Therapeutics' score of 0.00 indicating that Talphera is being referred to more favorably in the media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Talphera 0 Very Positive mention(s) 2 Positive mention(s) 0 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Neutral Iterum Therapeutics 0 Very Positive mention(s) 0 Positive mention(s) 3 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Neutral SummaryTalphera beats Iterum Therapeutics on 10 of the 15 factors compared between the two stocks. Get Talphera News Delivered to You Automatically Sign up to receive the latest news and ratings for TLPH and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding TLPH and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart TLPH vs. The Competition Export to ExcelMetricTalpheraMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$9.99M$2.57B$5.76B$9.58BDividend YieldN/A1.67%4.41%4.10%P/E Ratio-1.2322.6131.1026.05Price / Sales15.55554.26433.22103.03Price / CashN/A180.4637.7358.48Price / Book1.545.939.536.61Net Income-$13M$31.83M$3.26B$265.56M7 Day Performance15.85%1.89%2.10%1.97%1 Month Performance13.26%1.33%2.81%-0.36%1 Year Performance-46.45%8.84%30.56%19.03% Talphera Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)TLPHTalphera2.8796 of 5 stars$0.49+1.2%$5.00+914.8%-45.3%$9.99M$650K-1.2319Gap DownITRMIterum Therapeutics1.8852 of 5 stars$0.77+8.4%$9.00+1,062.8%-38.5%$33.72MN/A-0.8910SCYXSCYNEXIS1.0268 of 5 stars$0.86-2.8%N/A-51.4%$33.36M$3.75M-1.5360News CoverageAnalyst RevisionCLSDClearside Biomedical1.8858 of 5 stars$0.42+5.2%$4.20+890.6%-59.7%$33.29M$1.66M-1.1530RANIRani Therapeutics2.6886 of 5 stars$0.53+5.0%$7.33+1,296.8%-79.7%$33.19M$1.03M-0.58110EQEquillium0.9699 of 5 stars$0.94+5.8%$3.00+220.2%+102.2%$33.15M$41.10M-2.3840Gap DownHigh Trading VolumeAKTXAkari Therapeutics2.4143 of 5 stars$1.03-2.4%$5.00+387.8%-75.1%$32.98MN/A0.009ALXOALX Oncology3.0838 of 5 stars$0.61-0.1%$3.30+437.5%-49.8%$32.79MN/A-0.2540Analyst RevisionESLAEstrella Immunopharma2.3011 of 5 stars$0.87+0.6%$16.00+1,739.1%-26.5%$31.47MN/A-3.35N/ATPSTTempest Therapeutics1.2297 of 5 stars$8.50+6.1%$30.00+252.9%-47.2%$31.28MN/A-0.4720CLNNClene3.2603 of 5 stars$3.76-1.5%$40.00+963.5%+6.8%$31.10M$340K-0.93100Analyst Forecast Related Companies and Tools Related Companies Iterum Therapeutics Alternatives SCYNEXIS Alternatives Clearside Biomedical Alternatives Rani Therapeutics Alternatives Equillium Alternatives Akari Therapeutics Alternatives ALX Oncology Alternatives Estrella Immunopharma Alternatives Tempest Therapeutics Alternatives Clene Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:TLPH) was last updated on 8/23/2025 by MarketBeat.com Staff From Our PartnersBONUS GUIDE - Ben Stein Prepares For the Next Financial CrisisWith inflation high, debt soaring, and global tensions rising, a financial storm may be brewing. 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