Baker Bros. Advisors Lp Top Holdings and 13F Report (2026) About Baker Bros. Advisors LpInvestment ActivityBaker Bros. Advisors Lp has $17.42 billion in total holdings as of March 31, 2026.Baker Bros. Advisors Lp owns shares of 84 different stocks, but just 13 companies or ETFs make up 80% of its holdings.Approximately 3.94% of the portfolio was purchased this quarter.About 1.66% of the portfolio was sold this quarter.This quarter, Baker Bros. Advisors Lp has purchased 86 new stocks and bought additional shares in 18 stocks.Baker Bros. Advisors Lp sold shares of 6 stocks and completely divested from 9 stocks this quarter.Largest Holdings Incyte $2,893,664,057BeOne Medicines Ltd. $2,613,054,769Insmed $1,213,500,071Madrigal Pharmaceuticals $1,121,116,222ACADIA Pharmaceuticals $954,880,319 Largest New Holdings this Quarter 604749101 - Mirum Pharmaceuticals $41,199,171 Holding30054Y107 - Evommune, Inc. $19,481,496 Holding01021M104 - Aktis Oncology, Inc. $17,824,719 Holding370920100 - Generate Biomedicines, Inc. $17,795,025 Holding20451W101 - Compass Pathways $12,966,302 Holding Largest Purchases this Quarter Praxis Precision Medicines, Inc. 626,710 shares (about $201.92M)Insmed 828,365 shares (about $135.45M)GRAIL, Inc. 1,943,281 shares (about $100.43M)Mirum Pharmaceuticals 445,975 shares (about $41.20M)Crinetics Pharmaceuticals 702,596 shares (about $25.52M) Largest Sales this Quarter Immunocore 1,588,259 shares (about $47.89M)BioNTech 249,180 shares (about $22.15M)Roivant Sciences 687,294 shares (about $19.04M)Immatics 1,177,401 shares (about $11.59M)Arrowhead Pharmaceuticals 182,862 shares (about $11.47M) Sector Allocation Over TimeMap of 500 Largest Holdings ofBaker Bros. Advisors Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorINCYIncyte$2,893,664,057$39,625 â–²0.0%30,744,41216.6%MedicalBeOne Medicines Ltd.$2,613,054,7690.0%8,799,05315.0%SPONSORED ADSINSMInsmed$1,213,500,071$135,454,245 â–²12.6%7,421,1117.0%MedicalMDGLMadrigal Pharmaceuticals$1,121,116,2220.0%2,141,7016.4%MedicalACADACADIA Pharmaceuticals$954,880,3190.0%42,896,6905.5%MedicalRVMDRevolution Medicines$929,258,468$9,725,000 â–²1.1%9,555,3575.3%MedicalCELCCelcuity$903,508,4990.0%7,915,7925.2%MedicalKODKodiak Sciences$759,319,3700.0%19,919,1864.4%MedicalKYMRKymera Therapeutics$721,061,6860.0%8,657,2424.1%MedicalSMMTSummit Therapeutics$689,974,5540.0%36,391,0634.0%MedicalPraxis Precision Medicines, Inc.$564,862,864$201,919,695 â–²55.6%1,753,1983.2%COMRYTMRhythm Pharmaceuticals$487,421,8870.0%5,604,4832.8%MedicalALKSAlkermes$354,033,7610.0%10,012,2672.0%MedicalGRAIL, Inc.$208,198,772$100,428,762 â–²93.2%4,028,6141.2%COMEWTXEdgewise Therapeutics$207,142,1100.0%6,575,9401.2%MedicalIONSIonis Pharmaceuticals$153,763,820$19,214,480 â–²14.3%2,047,7270.9%MedicalKiniksa Pharmaceuticals International, plc$136,083,7450.0%2,826,2460.8%ORD SHS CL AIMVTImmunovant$135,573,7640.0%5,457,8810.8%MedicalROIVRoivant Sciences$134,835,927$19,038,044 â–¼-12.4%4,867,7230.8%MedicalIDYAIDEAYA Biosciences$131,497,880$10,918,597 â–²9.1%3,946,5150.8%MedicalARWRArrowhead Pharmaceuticals$124,947,494$11,465,447 â–¼-8.4%1,992,7830.7%MedicalSTOKStoke Therapeutics$108,642,8540.0%3,336,6970.6%MedicalIMTXImmatics$107,420,259$11,585,626 â–¼-9.7%10,916,6930.6%MedicalABCLAbCellera Biologics$105,663,024$9,598,540 â–²10.0%30,275,9380.6%MedicalAbivax S.A.$97,519,8850.0%875,7960.6%SPONSORED ADSCRNXCrinetics Pharmaceuticals$85,405,209$25,518,287 â–²42.6%2,351,4650.5%MedicalREPLReplimune Group$84,496,8200.0%11,045,3360.5%MedicalCelcuity Inc.$74,868,5630.0%30,750,0000.4%Note 2.75% 8/1/2031NRIXNurix Therapeutics$72,207,6180.0%4,658,5560.4%MedicalDNLIDenali Therapeutics$71,648,5440.0%3,731,6950.4%MedicalDianthus Therapeutics, Inc.$71,513,603$5,237,028 â–²7.9%852,1640.4%COMGLUEMonte Rosa Therapeutics$71,487,3570.0%4,345,7360.4%MedicalGPCRStructure Therapeutics$69,047,8980.0%1,432,5290.4%MedicalTRDAEntrada Therapeutics$64,017,8530.0%5,072,7300.4%MedicalBCYCBicycle Therapeutics$50,508,0560.0%10,885,3570.3%MedicalSpyre Therapeutics, Inc.$50,440,0000.0%1,000,0000.3%COMRapport Therapeutics, Inc.$48,408,4460.0%1,547,0900.3%COMAlumis Inc.$44,335,375$9,913,500 â–²28.8%2,012,5000.3%COMMIRMMirum Pharmaceuticals$41,199,171$41,199,171 â–²New Holding445,9750.2%MedicalVRDNViridian Therapeutics$38,566,0220.0%1,971,6780.2%MedicalELVNEnliven Therapeutics$35,483,487$24,844,372 â–²233.5%905,1910.2%MedicalPRLDPrelude Therapeutics$34,623,4780.0%10,123,8240.2%MedicalDBV Technologies S.A.$30,529,1680.0%1,461,4250.2%SPONSORED ADSDSGNDesign Therapeutics$27,514,806$3,754,633 â–²15.8%2,585,9780.2%MedicalCNTACentessa Pharmaceuticals$26,642,2300.0%670,7510.2%MedicalCTMXCytomX Therapeutics$23,386,382$3,407,500 â–²17.1%4,975,8260.1%MedicalJade Biosciences, Inc.$23,057,9750.0%1,641,1370.1%COMIRONDisc Medicine$22,357,069$806,092 â–²3.7%349,6570.1%MedicalIMCRImmunocore$22,142,070$47,886,010 â–¼-68.4%734,3970.1%MedicalXENEXenon Pharmaceuticals$21,527,5950.0%370,2080.1%MedicalCLDXCelldex Therapeutics$21,105,5360.0%665,3700.1%MedicalNeurogene Inc.$19,992,4910.0%991,6910.1%COMEvommune, Inc.$19,481,496$19,481,496 â–²New Holding847,3900.1%COM SHSTectonic Therapeutic, Inc.$18,786,727$9,137,367 â–¼-32.7%607,7880.1%COMContineum Therapeutics, Inc.$18,556,1440.0%1,420,8380.1%CL AARGXargenex$18,383,3140.0%25,1740.1%MedicalCERSCerus$18,215,1880.0%10,008,3450.1%MedicalTSHATaysha Gene Therapies$17,901,2590.0%4,004,7560.1%MedicalAktis Oncology, Inc.$17,824,719$17,824,719 â–²New Holding996,3510.1%COMGenerate Biomedicines, Inc.$17,795,025$17,795,025 â–²New Holding1,423,6020.1%COM SHSSionna Therapeutics, Inc.$16,036,0000.0%400,0000.1%COMDyne Therapeutics, Inc.$14,747,8300.0%813,4490.1%COMXNCRXencor$13,291,3980.0%1,102,1060.1%MedicalCMPSCompass Pathways$12,966,302$12,966,302 â–²New Holding2,344,7200.1%MedicalRLAYRelay Therapeutics$11,543,1640.0%1,160,1170.1%MedicalSERASera Prognostics$11,161,2850.0%5,498,1700.1%MedicalBNTXBioNTech$10,642,758$22,147,119 â–¼-67.5%119,7430.1%MedicalPHVSPharvaris$10,593,7500.0%375,0000.1%MedicalRCUSArcus Biosciences$8,977,414$3,145,414 â–²53.9%415,6210.1%MedicalMapLight Therapeutics, Inc.$7,414,4530.0%364,7050.0%COMABSIAbsci$6,404,4090.0%2,134,8030.0%MedicalWVEWAVE Life Sciences$5,964,126$3,469,669 â–²139.1%822,6380.0%MedicalvTv Therapeutics, Inc.$5,882,1330.0%148,3140.0%CL AEikon Therapeutics, Inc.$5,877,772$5,877,772 â–²New Holding555,5550.0%COMTARAProtara Therapeutics$5,062,1090.0%971,6140.0%MedicalSagimet Biosciences Inc.$4,979,4040.0%952,9960.0%COM SER ALB Pharmaceuticals Inc.$4,932,0000.0%200,0000.0%COM SHSVSTMVerastem$3,099,212$3,099,212 â–²New Holding584,7570.0%MedicalTCRXTScan Therapeutics$2,812,6400.0%2,784,7920.0%MedicalSkye Bioscience, Inc.$968,144$76,582 â–²8.6%1,575,2430.0%COMSANASana Biotechnology$894,1910.0%310,4830.0%MedicalAligos Therapeutics, Inc.$617,0990.0%83,0550.0%COMTYRATyra Biosciences$406,2480.0%10,6070.0%MedicalSRZNWSurrozen$13,3330.0%833,3330.0%MedicalRAREUltragenyx Pharmaceutical$0$63,771,916 â–¼-100.0%00.0%MedicalTERNTerns Pharmaceuticals$0$38,380,000 â–¼-100.0%00.0%MedicalBCRXBioCryst Pharmaceuticals$0$22,017,271 â–¼-100.0%00.0%MedicalVTYXVentyx Biosciences$0$21,213,998 â–¼-100.0%00.0%MedicalNUVLNuvalent$0$14,478,623 â–¼-100.0%00.0%MedicalFDMT4D Molecular Therapeutics$0$3,568,028 â–¼-100.0%00.0%MedicalVIRVir Biotechnology$0$3,271,510 â–¼-100.0%00.0%MedicalKALAKALA BIO$0$1,002,874 â–¼-100.0%00.0%MedicalACRVAcrivon Therapeutics$0$54,970 â–¼-100.0%00.0%MedicalShowing largest 100 holdings. 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