Baker Bros. Advisors Lp Top Holdings and 13F Report (2026) About Baker Bros. Advisors LpInvestment ActivityBaker Bros. Advisors Lp has $19.96 billion in total holdings as of June 30, 2026.Baker Bros. Advisors Lp owns shares of 84 different stocks, but just 13 companies or ETFs make up 80% of its holdings.Approximately 3.80% of the portfolio was purchased this quarter.About 2.34% of the portfolio was sold this quarter.This quarter, Baker Bros. Advisors Lp has purchased 84 new stocks and bought additional shares in 16 stocks.Baker Bros. Advisors Lp sold shares of 7 stocks and completely divested from 8 stocks this quarter.Largest Holdings Incyte $3,487,217,729BeOne Medicines Ltd. $2,508,182,548Revolution Medicines $2,143,111,899Madrigal Pharmaceuticals $1,150,754,190ACADIA Pharmaceuticals $1,085,696,471 Largest New Holdings this Quarter 81728A207 - Faeth Therapeutics, Inc. $32,160,275 Holding23282W605 - Cytokinetics $17,997,836 Holding45826J105 - Intellia Therapeutics $15,739,525 Holding698955101 - Parabilis Medicines, Inc. $13,685,000 Holding05348Y105 - Avalyn Pharma Inc. $11,522,000 Holding Largest Purchases this Quarter Revolution Medicines 1,888,000 shares (about $353.58M)Insmed 1,375,000 shares (about $146.60M)IDEAYA Biosciences 1,063,515 shares (about $39.64M)Faeth Therapeutics, Inc. 1,286,411 shares (about $32.16M)Relay Therapeutics 1,666,666 shares (about $31.18M) Largest Sales this Quarter Edgewise Therapeutics 2,874,221 shares (about $116.78M)Summit Therapeutics 3,604,715 shares (about $52.52M)Immatics 1,408,128 shares (about $14.26M)Cerus 3,612,914 shares (about $10.55M)Jade Biosciences, Inc. 410,711 shares (about $9.13M) Sector Allocation Over TimeMap of 500 Largest Holdings ofBaker Bros. Advisors Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorINCYIncyte$3,487,217,729$2,031,184 ▲0.1%30,762,33017.5%HealthcareBeOne Medicines Ltd.$2,508,182,548$716,415 ▲0.0%8,801,56712.6%SPONSORED ADSRVMDRevolution Medicines$2,143,111,899$353,584,640 ▲19.8%11,443,35710.7%HealthcareMDGLMadrigal Pharmaceuticals$1,150,754,190$767,838 ▲0.1%2,143,1315.8%HealthcareACADACADIA Pharmaceuticals$1,085,696,471$410,214 ▲0.0%42,912,9045.4%HealthcareKYMRKymera Therapeutics$992,725,9400.0%8,657,2425.0%HealthcareINSMInsmed$937,841,355$146,602,500 ▲18.5%8,796,1114.7%HealthcareCELCCelcuity$828,150,1590.0%7,915,7924.2%HealthcareKODKodiak Sciences$776,051,4870.0%19,919,1863.9%HealthcareRYTMRhythm Pharmaceuticals$622,265,7470.0%5,604,4833.1%HealthcarePraxis Precision Medicines, Inc.$586,953,1580.0%1,753,1982.9%COMALKSAlkermes$524,592,7290.0%10,012,2672.6%HealthcareSMMTSummit Therapeutics$477,697,090$52,520,698 ▼-9.9%32,786,3482.4%HealthcareGRAIL, Inc.$275,033,4780.0%4,028,6141.4%COMABCLAbCellera Biologics$259,145,283$21,479,170 ▲9.0%33,012,1381.3%HealthcareIMVTImmunovant$209,419,027$873,128 ▼-0.4%5,435,2201.0%HealthcareIDYAIDEAYA Biosciences$186,723,818$39,637,204 ▲26.9%5,010,0300.9%HealthcareKiniksa Pharmaceuticals International, plc$181,275,420$536,988 ▲0.3%2,834,6430.9%ORD SHS CL AROIVRoivant Sciences$166,928,649$5,340,068 ▼-3.1%4,716,8310.8%HealthcareARWRArrowhead Pharmaceuticals$162,431,7420.0%1,992,7830.8%HealthcareIONSIonis Pharmaceuticals$162,364,2740.0%2,047,7270.8%HealthcareEWTXEdgewise Therapeutics$150,400,843$116,779,599 ▼-43.7%3,701,7190.8%HealthcareREPLReplimune Group$122,271,8700.0%11,045,3360.6%HealthcareNRIXNurix Therapeutics$113,016,5690.0%4,658,5560.6%HealthcareSTOKStoke Therapeutics$109,176,7260.0%3,336,6970.5%HealthcareGLUEMonte Rosa Therapeutics$105,166,8110.0%4,345,7360.5%HealthcareIMTXImmatics$96,321,763$14,264,337 ▼-12.9%9,508,5650.5%HealthcareDNLIDenali Therapeutics$96,047,122$67,927 ▲0.1%3,734,3360.5%HealthcareCRNXCrinetics Pharmaceuticals$87,991,8200.0%2,351,4650.4%HealthcareDianthus Therapeutics, Inc.$83,068,9470.0%852,1640.4%COMGPCRStructure Therapeutics$76,883,8310.0%1,432,5290.4%HealthcareCelcuity Inc.$69,158,6870.0%30,750,0000.3%Note 2.75% 8/1/2031Rapport Therapeutics, Inc.$64,467,2400.0%1,547,0900.3%COMAlumis Inc.$56,631,7500.0%2,012,5000.3%COMPRLDPrelude Therapeutics$53,959,9820.0%10,123,8240.3%HealthcareRLAYRelay Therapeutics$52,889,110$31,183,321 ▲143.7%2,826,7830.3%HealthcareMIRMMirum Pharmaceuticals$52,210,2930.0%445,9750.3%HealthcareBCYCBicycle Therapeutics$46,153,9140.0%10,885,3570.2%HealthcareELVNEnliven Therapeutics$45,938,4430.0%905,1910.2%HealthcareCLDXCelldex Therapeutics$44,004,955$19,246,537 ▲77.7%1,182,6110.2%HealthcareVRDNViridian Therapeutics$43,776,169$7,556,444 ▲20.9%2,383,0250.2%HealthcareDSGNDesign Therapeutics$38,756,882$1,337,780 ▲3.6%2,678,4300.2%HealthcareTRDAEntrada Therapeutics$37,335,2930.0%5,072,7300.2%HealthcareFaeth Therapeutics, Inc.$32,160,275$32,160,275 ▲New Holding1,286,4110.2%COMAktis Oncology, Inc.$32,112,3930.0%996,3510.2%COMNeurogene Inc.$31,188,6820.0%991,6910.2%COMJade Biosciences, Inc.$27,340,066$9,125,999 ▼-25.0%1,230,4260.1%COMTSHATaysha Gene Therapies$27,272,3880.0%4,004,7560.1%HealthcareRCUSArcus Biosciences$26,045,677$13,232,082 ▲103.3%844,8160.1%HealthcareIRONDisc Medicine$25,573,9130.0%349,6570.1%HealthcareABSIAbsci$24,742,3670.0%2,134,8030.1%HealthcareGenerate Biomedicines, Inc.$24,016,1660.0%1,423,6020.1%COM SHSDBV Technologies S.A.$23,967,3700.0%1,461,4250.1%SPONSORED ADSXENEXenon Pharmaceuticals$22,345,7550.0%370,2080.1%HealthcareTectonic Therapeutic, Inc.$20,892,7130.0%607,7880.1%COMCERSCerus$18,674,659$10,549,709 ▼-36.1%6,395,4310.1%HealthcareCTMXCytomX Therapeutics$18,659,3480.0%4,975,8260.1%HealthcareDyne Therapeutics, Inc.$18,066,7020.0%813,4490.1%COMCYTKCytokinetics$17,997,836$17,997,836 ▲New Holding211,2670.1%HealthcareXNCRXencor$17,743,9070.0%1,102,1060.1%HealthcareSionna Therapeutics, Inc.$17,596,0000.0%400,0000.1%COMNTLAIntellia Therapeutics$15,739,525$15,739,525 ▲New Holding930,2320.1%HealthcareParabilis Medicines, Inc.$13,685,000$13,685,000 ▲New Holding500,0000.1%COMMapLight Therapeutics, Inc.$13,071,0270.0%364,7050.1%COMAvalyn Pharma Inc.$11,522,000$11,522,000 ▲New Holding350,0000.1%COM SHSEvommune, Inc.$11,261,8130.0%847,3900.1%COM SHSBNTXBioNTech$11,142,0860.0%119,7430.1%HealthcareTNGXTango Therapeutics$10,419,990$10,419,990 ▲New Holding333,3330.1%HealthcareAvalo Therapeutics, Inc.$10,164,000$10,164,000 ▲New Holding550,0000.1%COMSERASera Prognostics$10,006,6690.0%5,498,1700.1%HealthcareVSTMVerastem$9,547,471$7,313,699 ▲327.4%2,499,3380.0%HealthcareSagimet Biosciences Inc.$7,366,6590.0%952,9960.0%COM SER AEikon Therapeutics, Inc.$7,249,9930.0%555,5550.0%COMLB Pharmaceuticals Inc.$6,491,0000.0%200,0000.0%COM SHSvTv Therapeutics, Inc.$5,584,0220.0%148,3140.0%CL AWVEWAVE Life Sciences$4,779,5270.0%822,6380.0%HealthcareTARAProtara Therapeutics$3,711,5650.0%971,6140.0%HealthcareTCRXTScan Therapeutics$2,729,3750.0%2,784,7920.0%HealthcareIMNMImmunome$1,171,934$1,171,934 ▲New Holding55,3060.0%HealthcareSkye Bioscience, Inc.$1,092,1160.0%1,575,2430.0%COMSANASana Biotechnology$1,083,5860.0%310,4830.0%HealthcareAligos Therapeutics, Inc.$479,2270.0%83,0550.0%COMTYRATyra Biosciences$338,7880.0%10,6070.0%HealthcareSRZNWSurrozen$13,7500.0%833,3330.0%HealthcareAbivax S.A.$0$97,519,885 ▼-100.0%00.0%SPONSORED ADSSpyre Therapeutics, Inc.$0$50,440,000 ▼-100.0%00.0%COMCNTACentessa Pharmaceuticals$0$26,642,230 ▼-100.0%00.0%HealthcareIMCRImmunocore$0$22,142,070 ▼-100.0%00.0%HealthcareContineum Therapeutics, Inc.$0$18,556,144 ▼-100.0%00.0%CL AARGXargenex$0$18,383,314 ▼-100.0%00.0%HealthcareCMPSCompass Pathways$0$12,966,302 ▼-100.0%00.0%HealthcarePHVSPharvaris$0$10,593,750 ▼-100.0%00.0%HealthcareShowing largest 100 holdings. 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