Rock Springs Capital Management Lp Top Holdings and 13F Report (2026) About Rock Springs Capital Management LpInvestment ActivityRock Springs Capital Management Lp has $2.05 billion in total holdings as of June 30, 2026.Rock Springs Capital Management Lp owns shares of 104 different stocks, but just 40 companies or ETFs make up 80% of its holdings.Approximately 12.50% of the portfolio was purchased this quarter.About 12.84% of the portfolio was sold this quarter.This quarter, Rock Springs Capital Management Lp has purchased 100 new stocks and bought additional shares in 40 stocks.Rock Springs Capital Management Lp sold shares of 30 stocks and completely divested from 13 stocks this quarter.Largest Holdings Revolution Medicines $206,983,729Travere Therapeutics $123,792,910Eli Lilly and Company $118,383,741Madrigal Pharmaceuticals $93,965,713Mirum Pharmaceuticals $93,438,835 Largest New Holdings this Quarter K08588103 - ASCENDIS PHARMA A/S $45,009,000 Holding05348Y105 - AVALYN PHARMACEUTICALS INC $21,823,261 Holding423494103 - HEMAB THERAPEUTICS HLDGS INC $21,135,617 Holding698955101 - PARABILIS MEDICINES INC $15,820,626 Holding682143102 - Omeros $6,832,925 Holding Largest Purchases this Quarter ASCENDIS PHARMA A/S 168,750 shares (about $45.01M)Travere Therapeutics 701,115 shares (about $39.83M)AVALYN PHARMACEUTICALS INC 662,918 shares (about $21.82M)HEMAB THERAPEUTICS HLDGS INC 575,432 shares (about $21.14M)PARABILIS MEDICINES INC 578,028 shares (about $15.82M) Largest Sales this Quarter argenex 45,750 shares (about $42.45M)Revolution Medicines 104,255 shares (about $19.52M)Enliven Therapeutics 361,875 shares (about $18.37M)Agios Pharmaceuticals 266,600 shares (about $9.89M)Ultragenyx Pharmaceutical 250,918 shares (about $8.38M) Sector Allocation Over TimeMap of 500 Largest Holdings ofRock Springs Capital Management Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorRVMDRevolution Medicines$206,983,729$19,524,876 â–¼-8.6%1,105,21010.1%HealthcareTVTXTravere Therapeutics$123,792,910$39,830,343 â–²47.4%2,179,0696.0%HealthcareLLYEli Lilly and Company$118,383,7410.0%98,7005.8%HealthcareMDGLMadrigal Pharmaceuticals$93,965,713$2,147,800 â–²2.3%174,9994.6%HealthcareMIRMMirum Pharmaceuticals$93,438,835$1,539,353 â–¼-1.6%798,1454.6%HealthcareRYTMRhythm Pharmaceuticals$76,899,156$316,436 â–²0.4%692,5983.8%HealthcareKYMRKymera Therapeutics$51,963,399$5,012,799 â–¼-8.8%453,1562.5%HealthcareARGXargenex$48,939,868$42,445,478 â–¼-46.4%52,7502.4%HealthcareASCENDIS PHARMA A/S$45,009,000$45,009,000 â–²New Holding168,7502.2%ORD SHSXENEXenon Pharmaceuticals$41,280,627$4,775,261 â–¼-10.4%683,9072.0%HealthcareSRRKScholar Rock$39,349,860$1,340,020 â–¼-3.3%715,4521.9%HealthcareINSMInsmed$38,612,433$5,101,767 â–²15.2%362,1501.9%HealthcarePENPenumbra$36,548,063$1,499,813 â–¼-3.9%115,7501.8%HealthcareGPCRStructure Therapeutics$34,365,813$5,367 â–²0.0%640,3171.7%HealthcareRAREUltragenyx Pharmaceutical$32,316,678$8,378,152 â–¼-20.6%967,8551.6%HealthcareIRTCiRhythm Technologies$32,074,868$939,705 â–²3.0%269,6501.6%HealthcareISRGIntuitive Surgical$30,406,613$2,203,147 â–¼-6.8%76,4601.5%HealthcareAGILON HEALTH INC$28,145,468$278,668 â–²1.0%262,6001.4%COM NEWUNHUnitedHealth Group$26,496,413$4,468,023 â–²20.3%63,7501.3%HealthcareCLDXCelldex Therapeutics$26,015,223$1,818,676 â–²7.5%699,1461.3%HealthcareERASErasca$25,687,388$5,471,836 â–²27.1%1,402,1501.3%HealthcareNBIXNeurocrine Biosciences$24,395,441$960,649 â–¼-3.8%144,7501.2%HealthcareELVNEnliven Therapeutics$23,579,719$18,365,156 â–¼-43.8%464,6251.2%HealthcareTHCTenet Healthcare$23,385,0000.0%125,0001.1%HealthcareDXCMDexCom$23,101,050$848,610 â–¼-3.5%343,0001.1%HealthcareACRSAclaris Therapeutics$22,908,514$751,804 â–¼-3.2%4,330,5321.1%HealthcareMINIMED GROUP INC$22,724,000$6,951,750 â–²44.1%1,520,0001.1%COMBSXBoston Scientific$22,556,380$563,376 â–²2.6%528,5001.1%HealthcarePHVSPharvaris$22,419,355$96,824 â–²0.4%648,3331.1%HealthcareAVALYN PHARMACEUTICALS INC$21,823,261$21,823,261 â–²New Holding662,9181.1%COM SHSHEMAB THERAPEUTICS HLDGS INC$21,135,617$21,135,617 â–²New Holding575,4321.0%COM SHSDYNE THERAPEUTICS INC$20,925,240$667,277 â–¼-3.1%942,1541.0%COMALNYAlnylam Pharmaceuticals$20,093,753$2,182,468 â–¼-9.8%66,7501.0%HealthcareCOGTCogent Biosciences$19,965,988$4,188,811 â–¼-17.3%515,9171.0%HealthcareAGIOAgios Pharmaceuticals$19,763,413$9,893,526 â–¼-33.4%532,5631.0%HealthcareNAMSNewAmsterdam Pharma$19,749,194$205,034 â–¼-1.0%582,7441.0%HealthcareVERAVera Therapeutics$18,347,629$3,261,203 â–¼-15.1%427,5840.9%HealthcareTARSTarsus Pharmaceuticals$17,439,856$3,267,090 â–²23.1%277,0870.9%HealthcareHEARTFLOW INC$16,826,490$29,340 â–²0.2%573,5000.8%COMMBX BIOSCIENCES INC$16,461,634$565,855 â–²3.6%298,2180.8%COMCYTKCytokinetics$16,014,016$12,149,457 â–²314.4%187,9800.8%HealthcareBICARA THERAPEUTICS INC$15,892,641$1,371,411 â–²9.4%535,2860.8%COMPARABILIS MEDICINES INC$15,820,626$15,820,626 â–²New Holding578,0280.8%COMZLABZai Lab$15,479,4330.0%814,7070.8%HealthcareDHRDanaher$14,533,624$2,819,104 â–²24.1%76,3000.7%HealthcareTNGXTango Therapeutics$14,271,784$2,176,821 â–²18.0%456,5510.7%HealthcareEVHEvolent Health$13,550,000$948,500 â–¼-6.5%2,500,0000.7%HealthcarePTCTPTC Therapeutics$13,238,648$40,785 â–²0.3%162,2980.6%HealthcareMLYSMineralys Therapeutics$13,083,978$1,219,496 â–²10.3%484,9510.6%HealthcareZENAS BIOPHARMA INC$12,742,7140.0%502,0770.6%COMARDXArdelyx$11,433,022$294,290 â–¼-2.5%2,241,7690.6%HealthcareINSPInspire Medical Systems$10,884,840$5,005,242 â–²85.1%244,0000.5%HealthcareBBIOBridgeBio Pharma$10,780,980$1,228,920 â–²12.9%144,7500.5%HealthcareALKSAlkermes$10,469,097$829,151 â–²8.6%199,8110.5%HealthcareSMMTSummit Therapeutics$10,417,550$72,850 â–²0.7%715,0000.5%HealthcareAZTAAzenta$10,284,560$4,238,872 â–¼-29.2%403,0000.5%HealthcareINDIVIOR PHARMACEUTICALS INC$10,072,865$1,866,865 â–²22.8%245,5000.5%COMSYKStryker$9,130,360$4,470,728 â–²95.9%29,0000.4%HealthcareAMLXAmylyx Pharmaceuticals$8,975,7610.0%499,7640.4%HealthcareCARIS LIFE SCIENCES INC$8,687,250$1,345,410 â–¼-13.4%487,5000.4%COMOMADA HEALTH INC$8,187,350$3,687,600 â–¼-31.1%373,0000.4%COMCMPXCompass Therapeutics$7,719,595$480,970 â–²6.6%3,524,9290.4%HealthcareIMNMImmunome$7,367,0430.0%347,6660.4%HealthcareEDAP TMS S A$7,179,480$41,440 â–²0.6%1,386,0000.4%SPONSORED ADRPHRPhreesia$7,171,101$992,985 â–²16.1%696,9000.4%HealthcareOMEROmeros$6,832,925$6,832,925 â–²New Holding718,4990.3%HealthcareDEFINIUM THERAPEUTICS INC$6,735,516$6,735,516 â–²New Holding143,1870.3%COM SHSCORTCorcept Therapeutics$6,260,400$1,891,163 â–²43.3%72,0000.3%HealthcareJANXJanux Therapeutics$5,637,2580.0%367,0090.3%HealthcareMOBIA MED INC$5,603,880$5,603,880 â–²New Holding418,2000.3%COMMON STOCKRCUSArcus Biosciences$5,549,4000.0%180,0000.3%HealthcareTMOThermo Fisher Scientific$5,013,6000.0%10,0000.2%HealthcareTRVITrevi Therapeutics$4,849,000$4,849,000 â–²New Holding260,0000.2%HealthcareSIONNA THERAPEUTICS INC$4,373,8820.0%99,4290.2%COMCVSCVS Health$4,138,0000.0%40,0000.2%HealthcareEYPTEyepoint Pharmaceuticals$3,839,822$139,854 â–²3.8%268,5190.2%HealthcareOCULOcular Therapeutix$3,768,0910.0%383,7160.2%HealthcareSPYRE THERAPEUTICS INC$3,751,310$3,751,310 â–²New Holding42,2540.2%COM NEWTALPHERA INC$3,696,8620.0%3,589,1860.2%COM NEWROIVRoivant Sciences$3,574,390$141,560 â–²4.1%101,0000.2%HealthcarePCVXVaxcyte$3,502,3330.0%60,2500.2%HealthcareNEUROGENE INC$3,357,288$75,826 â–²2.3%106,7500.2%COMIPSCCentury Therapeutics$3,195,6500.0%1,304,3470.2%HealthcareATECAlphatec$3,114,000$86,500 â–²2.9%360,0000.2%HealthcareNVONovo Nordisk A/S$3,044,190$1,270,410 â–¼-29.4%63,5000.1%HealthcareOLMAOlema Pharmaceuticals$2,942,077$810,648 â–²38.0%235,1780.1%HealthcareNGENFNervGen Pharma$2,488,956$2,488,956 â–²New Holding1,208,2310.1%HealthcareMDTMedtronic$2,417,307$2,417,307 â–²New Holding30,9000.1%HealthcareTEVATeva Pharmaceutical Industries$1,998,920$457,380 â–²29.7%59,0000.1%HealthcareDIANTHUS THERAPEUTICS INC$1,981,378$626,894 â–¼-24.0%20,3260.1%COMSAGIMET BIOSCIENCES INC$1,932,500$1,932,500 â–²New Holding250,0000.1%COM SER ACAPRCapricor Therapeutics$1,792,708$1,792,708 â–²New Holding74,4480.1%HealthcareLENZ THERAPEUTICS INC$1,462,3730.0%257,4600.1%COMALTAltimmune$1,433,254$1,433,254 â–²New Holding471,4650.1%HealthcareKAILERA THERAPEUTICS INC$1,431,950$1,431,950 â–²New Holding65,0000.1%COMMON STOCKSGRYSurgery Partners$1,411,200$2,083,200 â–¼-59.6%84,0000.1%HealthcareAXSMAxsome Therapeutics$1,346,235$1,346,235 â–²New Holding5,5000.1%HealthcareORUKA THERAPEUTICS INC$1,146,894$754,508 â–²192.3%12,0510.1%COMVKTXViking Therapeutics$994,755$2,750,205 â–¼-73.4%25,5000.0%HealthcareLEGNLegend Biotech$967,480$202,160 â–¼-17.3%33,5000.0%HealthcareShowing largest 100 holdings. 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