Rock Springs Capital Management Lp Top Holdings and 13F Report (2026) About Rock Springs Capital Management LpInvestment ActivityRock Springs Capital Management Lp has $1.70 billion in total holdings as of March 31, 2026.Rock Springs Capital Management Lp owns shares of 100 different stocks, but just 38 companies or ETFs make up 80% of its holdings.Approximately 6.77% of the portfolio was purchased this quarter.About 16.28% of the portfolio was sold this quarter.This quarter, Rock Springs Capital Management Lp has purchased 98 new stocks and bought additional shares in 37 stocks.Rock Springs Capital Management Lp sold shares of 24 stocks and completely divested from 9 stocks this quarter.Largest Holdings Revolution Medicines $117,620,471Eli Lilly and Company $90,781,299Madrigal Pharmaceuticals $89,512,847Mirum Pharmaceuticals $74,947,340argenex $71,929,625 Largest New Holdings this Quarter 60365F109 - MINIMED GROUP INC $15,740,600 Holding45579U109 - INDIVIOR PHARMACEUTICALS INC $6,096,000 Holding863667101 - Stryker $4,863,132 Holding670100205 - Novo Nordisk A/S $3,307,500 Holding92686J106 - Viking Therapeutics $3,123,840 Holding Largest Purchases this Quarter Madrigal Pharmaceuticals 31,381 shares (about $16.43M)MINIMED GROUP INC 1,055,000 shares (about $15.74M)Boston Scientific 116,250 shares (about $7.29M)HEARTFLOW INC 294,800 shares (about $7.17M)PTC Therapeutics 99,919 shares (about $6.81M) Largest Sales this Quarter Amicus Therapeutics 1,908,869 shares (about $27.60M)SPDR S&P Biotech ETF 192,000 shares (about $24.52M)Travere Therapeutics 732,368 shares (about $21.76M)Revolution Medicines 125,805 shares (about $12.23M)Cogent Biosciences 224,875 shares (about $8.66M) Sector Allocation Over TimeMap of 500 Largest Holdings ofRock Springs Capital Management Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorRVMDRevolution Medicines$117,620,471$12,234,536 â–¼-9.4%1,209,4656.9%MedicalLLYEli Lilly and Company$90,781,299$6,162,459 â–¼-6.4%98,7005.4%MedicalMDGLMadrigal Pharmaceuticals$89,512,847$16,427,012 â–²22.5%170,9995.3%MedicalMIRMMirum Pharmaceuticals$74,947,340$4,526,620 â–²6.4%811,2944.4%MedicalARGXargenex$71,929,625$3,468,688 â–¼-4.6%98,5004.2%MedicalRYTMRhythm Pharmaceuticals$59,987,384$457,636 â–¼-0.8%689,7483.5%MedicalINSMInsmed$51,394,336$809,424 â–¼-1.6%314,3003.0%MedicalASNDAscendis Pharma A/S$44,373,620$2,172,935 â–¼-4.7%194,0002.6%MedicalXENEXenon Pharmaceuticals$44,369,613$1,440,259 â–¼-3.1%763,0202.6%MedicalTVTXTravere Therapeutics$43,910,013$21,758,653 â–¼-33.1%1,477,9542.6%MedicalKYMRKymera Therapeutics$41,384,3860.0%496,8712.4%MedicalPENPenumbra$39,568,5850.0%120,5002.3%MedicalISRGIntuitive Surgical$37,801,1800.0%82,0002.2%MedicalSRRKScholar Rock$36,369,355$311,625 â–²0.9%739,8162.1%MedicalELVNEnliven Therapeutics$32,398,800$1,101,324 â–²3.5%826,5001.9%MedicalBSXBoston Scientific$32,335,075$7,294,688 â–²29.1%515,3001.9%MedicalIRTCiRhythm Technologies$30,891,735$3,157,035 â–²11.4%261,7501.8%MedicalGPCRStructure Therapeutics$30,858,459$5,206,516 â–¼-14.4%640,2171.8%MedicalAGIOAgios Pharmaceuticals$27,035,6840.0%799,1631.6%MedicalRAREUltragenyx Pharmaceutical$25,533,294$1,015,405 â–¼-3.8%1,218,7731.5%MedicalALNYAlnylam Pharmaceuticals$24,484,380$909,893 â–²3.9%74,0001.4%MedicalCOGTCogent Biosciences$24,023,726$8,655,439 â–¼-26.5%624,1551.4%MedicalTHCTenet Healthcare$23,588,7500.0%125,0001.4%MedicalDXCMDexCom$22,331,680$521,240 â–²2.4%355,6001.3%MedicalCLDXCelldex Therapeutics$20,626,564$1,340,741 â–¼-6.1%650,2701.2%MedicalVERAVera Therapeutics$20,259,225$2,614,709 â–¼-11.4%503,5851.2%MedicalNBIXNeurocrine Biosciences$19,820,283$3,286,913 â–²19.9%150,4501.2%MedicalACLXArcellx$19,503,2100.0%169,8591.1%MedicalNAMSNewAmsterdam Pharma$18,847,2960.0%588,7941.1%MedicalPHVSPharvaris$18,236,307$625,201 â–²3.6%645,5331.1%MedicalERASErasca$17,854,128$2,455,461 â–²15.9%1,103,4691.1%MedicalDYNE THERAPEUTICS INC$17,625,950$1,074,076 â–²6.5%972,1981.0%COMCMPXCompass Therapeutics$17,485,079$3,289,819 â–¼-15.8%3,305,3081.0%MedicalACRSAclaris Therapeutics$16,772,438$70,909 â–²0.4%4,472,6501.0%MedicalTARSTarsus Pharmaceuticals$15,796,307$2,466,825 â–¼-13.5%225,1790.9%MedicalMINIMED GROUP INC$15,740,600$15,740,600 â–²New Holding1,055,0000.9%COMZLABZai Lab$15,324,639$59,458 â–²0.4%814,7070.9%MedicalUNHUnitedHealth Group$14,341,270$3,301,198 â–²29.9%53,0000.8%MedicalCNTACentessa Pharmaceuticals$13,974,608$1,104,732 â–²8.6%351,8280.8%MedicalHEARTFLOW INC$13,928,925$7,172,484 â–²106.2%572,5000.8%COMARDXArdelyx$13,773,8430.0%2,299,4730.8%MedicalSMMTSummit Therapeutics$13,461,6000.0%710,0000.8%MedicalAZTAAzenta$12,025,0830.0%569,1000.7%MedicalMLYSMineralys Therapeutics$11,912,855$329,279 â–²2.8%439,7510.7%MedicalDHRDanaher$11,660,4000.0%61,5000.7%MedicalPTCTPTC Therapeutics$11,023,298$6,807,482 â–²161.5%161,7980.6%MedicalCARIS LIFE SCIENCES INC$10,066,440$2,226,060 â–¼-18.1%563,0000.6%COMZENAS BIOPHARMA INC$9,815,6050.0%502,0770.6%COMBICARA THERAPEUTICS INC$9,728,100$1,193,400 â–²14.0%489,0950.6%COMBBIOBridgeBio Pharma$9,523,845$1,837,935 â–²23.9%128,2500.6%MedicalSLNOSoleno Therapeutics$8,612,830$341,496 â–²4.1%257,2530.5%MedicalMBX BIOSCIENCES INC$8,595,815$159,489 â–²1.9%287,9670.5%COMTNGXTango Therapeutics$8,094,2620.0%386,9150.5%MedicalREGNRegeneron Pharmaceuticals$7,803,6640.0%10,1000.5%MedicalIMNMImmunome$7,603,4550.0%347,6660.4%MedicalAMLXAmylyx Pharmaceuticals$6,946,7200.0%499,7640.4%MedicalOMADA HEALTH INC$6,800,370$2,501,430 â–¼-26.9%541,0000.4%COMINSPInspire Medical Systems$6,798,244$41,264 â–²0.6%131,8000.4%MedicalAPLSApellis Pharmaceuticals$6,547,433$492,818 â–²8.1%162,7500.4%MedicalALKSAlkermes$6,505,745$1,582,643 â–²32.1%183,9860.4%MedicalEVHEvolent Health$6,099,0000.0%2,675,0000.4%Computer and TechnologyINDIVIOR PHARMACEUTICALS INC$6,096,000$6,096,000 â–²New Holding200,0000.4%COMTERNTerns Pharmaceuticals$5,996,795$277,676 â–²4.9%113,7480.4%MedicalEDAPEdap Tms$5,126,160$340,380 â–²7.1%1,378,0000.3%MedicalJANXJanux Therapeutics$5,101,425$114,133 â–²2.3%367,0090.3%MedicalPHRPhreesia$5,031,352$2,314,556 â–¼-31.5%600,4000.3%MedicalTMOThermo Fisher Scientific$4,915,3000.0%10,0000.3%MedicalSYKStryker$4,863,132$4,863,132 â–²New Holding14,8000.3%MedicalSIONNA THERAPEUTICS INC$3,986,1090.0%99,4290.2%COMRCUSArcus Biosciences$3,888,0000.0%180,0000.2%MedicalXBISPDR S&P Biotech ETF$3,831,900$24,524,160 â–¼-86.5%30,0000.2%ETFATECAlphatec$3,808,000$516,800 â–²15.7%350,0000.2%MedicalPCVXVaxcyte$3,501,128$769,958 â–²28.2%60,2500.2%MedicalEYPTEyepoint Pharmaceuticals$3,335,1460.0%258,7390.2%MedicalNVONovo Nordisk A/S$3,307,500$3,307,500 â–²New Holding90,0000.2%MedicalOCULOcular Therapeutix$3,250,075$320,979 â–²11.0%383,7160.2%MedicalVKTXViking Therapeutics$3,123,840$3,123,840 â–²New Holding96,0000.2%MedicalCYTKCytokinetics$2,989,941$626,870 â–²26.5%45,3640.2%MedicalIPSCCentury Therapeutics$2,947,824$2,947,824 â–²New Holding1,304,3470.2%MedicalCVSCVS Health$2,872,800$2,872,800 â–²New Holding40,0000.2%MedicalROIVRoivant Sciences$2,686,900$228,525 â–²9.3%97,0000.2%MedicalTALPHERA INC$2,680,7630.0%3,589,1860.2%COM NEWOLMAOlema Pharmaceuticals$2,540,336$1,075,578 â–²73.4%170,3780.1%MedicalSGRYSurgery Partners$2,479,360$1,215,840 â–¼-32.9%208,0000.1%MedicalLENZ THERAPEUTICS INC$2,355,7590.0%257,4600.1%COMEWEdwards Lifesciences$2,314,312$4,292,288 â–¼-65.0%28,9000.1%MedicalDIANTHUS THERAPEUTICS INC$2,245,447$2,245,447 â–²New Holding26,7570.1%COMNEUROGENE INC$2,103,4740.0%104,3390.1%COMAGILON HEALTH INC$2,056,600$2,056,600 â–²New Holding260,0000.1%COM NEWCORTCorcept Therapeutics$2,025,5780.0%50,2500.1%MedicalACHCAcadia Healthcare$1,765,945$1,040,855 â–¼-37.1%75,5000.1%MedicalTEVATeva Pharmaceutical Industries$1,370,4600.0%45,5000.1%MedicalMLTXMoonLake Immunotherapeutics$1,150,0880.0%61,7000.1%MedicalJAZZJazz Pharmaceuticals$1,087,038$756,200 â–²228.6%5,7500.1%MedicalJASPER THERAPEUTICS INC$964,4560.0%1,100,7260.1%COM NEWLEGNLegend Biotech$732,645$121,203 â–²19.8%40,5000.0%MedicalGOSSGossamer Bio$528,718$544,478 â–¼-50.7%1,609,4920.0%MedicalFOLDAmicus Therapeutics$304,557$27,602,289 â–¼-98.9%21,0620.0%MedicalORUKA THERAPEUTICS INC$202,233$202,233 â–²New Holding4,1230.0%COMBCRXBioCryst Pharmaceuticals$119,952$119,952 â–²New Holding12,6000.0%MedicalShowing largest 100 holdings. 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