Siren, L.L.C. Top Holdings and 13F Report (2025) About Siren, L.L.C.Investment ActivitySiren, L.L.C. has $1.76 billion in total holdings as of March 31, 2025.Siren, L.L.C. owns shares of 116 different stocks, but just 30 companies or ETFs make up 80% of its holdings.Approximately 17.94% of the portfolio was purchased this quarter.About 19.12% of the portfolio was sold this quarter.This quarter, Siren, L.L.C. has purchased 117 new stocks and bought additional shares in 28 stocks.Siren, L.L.C. sold shares of 42 stocks and completely divested from 25 stocks this quarter.Largest Holdings Scholar Rock $297,387,661BeiGene $135,728,185Kymera Therapeutics $88,687,367Blueprint Medicines $64,273,041Crinetics Pharmaceuticals $56,636,013 Largest New Holdings this Quarter 09627Y109 - Blueprint Medicines $64,273,041 Holding254604101 - Disc Medicine $53,207,379 Holding76243J105 - Rhythm Pharmaceuticals $14,700,923 Holding86627T108 - Summit Therapeutics $13,406,550 Holding59267L107 - Metsera Inc $4,083,000 Holding Largest Purchases this Quarter Blueprint Medicines 726,167 shares (about $64.27M)Disc Medicine 1,071,865 shares (about $53.21M)Soleno Therapeutics 375,519 shares (about $26.83M)Edgewise Therapeutics 962,101 shares (about $21.17M)Rhythm Pharmaceuticals 277,533 shares (about $14.70M) Largest Sales this Quarter BeiGene 155,032 shares (about $42.20M)Lexicon Pharmaceuticals 35,402,689 shares (about $16.31M)Apogee Therapeutics Inc 152,331 shares (about $5.69M)Apellis Pharmaceuticals 237,862 shares (about $5.20M)NewAmsterdam Pharma 183,608 shares (about $3.76M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSiren, L.L.C. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorSRRKScholar Rock$297,387,6610.0%9,250,00516.9%MedicalBGNEBeiGene$135,728,185$42,195,059 ▼-23.7%498,6897.7%MedicalKYMRKymera Therapeutics$88,687,367$7,405,775 ▲9.1%3,240,3135.0%MedicalBPMCBlueprint Medicines$64,273,041$64,273,041 ▲New Holding726,1673.7%MedicalCRNXCrinetics Pharmaceuticals$56,636,013$2,648,285 ▲4.9%1,688,6113.2%MedicalAPLSApellis Pharmaceuticals$56,389,521$5,202,042 ▼-8.4%2,578,3963.2%MedicalIRONDisc Medicine$53,207,379$53,207,379 ▲New Holding1,071,8653.0%MedicalSLNOSoleno Therapeutics$51,968,229$26,830,833 ▲106.7%727,3373.0%MedicalASNDAscendis Pharma A/S$44,788,865$1,551,586 ▼-3.3%287,3662.5%MedicalMRUSMerus$43,919,526$10,903,625 ▲33.0%1,043,4672.5%MedicalBicara Therapeutics Inc$42,570,091$74,844 ▼-0.2%3,267,0832.4%COMCNTACentessa Pharmaceuticals$42,565,217$642,038 ▼-1.5%2,960,0292.4%MedicalNAMSNewAmsterdam Pharma$39,139,254$3,758,456 ▼-8.8%1,912,0302.2%MedicalEWTXEdgewise Therapeutics$37,321,768$21,166,222 ▲131.0%1,696,4442.1%MedicalARWRArrowhead Pharmaceuticals$34,014,271$2,953,145 ▼-8.0%2,669,8801.9%MedicalRNAAvidity Biosciences$32,785,207$492,541 ▼-1.5%1,110,6101.9%MedicalWVEWave Life Sciences$29,866,282$437,686 ▼-1.4%3,696,3221.7%MedicalTBLATaboola.com$29,410,0100.0%9,969,4951.7%Computer and TechnologyDyne Therapeutics Inc$28,430,144$14,335,754 ▲101.7%2,717,9871.6%COMSLDBSolid Biosciences$27,438,849$13,567,397 ▲97.8%7,415,9051.6%MedicalXENEXenon Pharmaceuticals$24,584,132$369,318 ▼-1.5%732,7611.4%MedicalApogee Therapeutics Inc$22,228,976$5,691,086 ▼-20.4%594,9941.3%COMRVMDRevolution Medicines$19,934,377$275,560 ▼-1.4%563,7551.1%MedicalTRVITrevi Therapeutics$18,013,258$265,859 ▼-1.5%2,863,7931.0%MedicalVERAVera Therapeutics$17,948,128$270,201 ▼-1.5%747,2161.0%MedicalPRTAProthena$15,883,993$2,273,473 ▲16.7%1,283,5550.9%MedicalBCYCBicycle Therapeutics$15,390,264$226,225 ▼-1.4%1,812,7520.9%MedicalSTOKStoke Therapeutics$14,944,858$1,644,858 ▲12.4%2,247,3470.9%MedicalRYTMRhythm Pharmaceuticals$14,700,923$14,700,923 ▲New Holding277,5330.8%MedicalSMMTSummit Therapeutics$13,406,550$13,406,550 ▲New Holding695,0000.8%MedicalSepterna Inc$12,752,5560.0%2,202,5140.7%COMRCUSArcus Biosciences$12,654,8040.0%1,612,0770.7%MedicalIHS(IHS)$12,306,2540.0%2,357,5200.7%Computer and TechnologyERASErasca$11,997,431$136,904 ▼-1.1%8,757,2490.7%MedicalDNLIDenali Therapeutics$11,168,469$170,141 ▼-1.5%821,5130.6%MedicalPCVXVaxcyte$11,159,704$167,956 ▼-1.5%295,5430.6%MedicalAMZNAmazon.com$10,749,690$3,805,200 ▲54.8%56,5000.6%Retail/WholesaleMSFTMicrosoft$10,698,615$2,064,645 ▲23.9%28,5000.6%Computer and TechnologyRemitly Global Inc$10,201,3390.0%490,4490.6%COMTSHATaysha Gene Therapies$9,055,484$121,956 ▼-1.3%6,514,7370.5%MedicalCGEMCullinan Therapeutics$9,034,114$135,859 ▼-1.5%1,193,4100.5%MedicalCRWDCrowdStrike$8,814,500$352,580 ▲4.2%25,0000.5%Computer and TechnologySLNSilence Therapeutics$7,867,329$118,262 ▼-1.5%2,789,8330.4%MedicalGOOGLAlphabet$7,840,712$6,758,232 ▲624.3%50,7030.4%Computer and TechnologyCartesian Therapeutics Inc$7,423,925$118,146 ▼-1.6%563,2720.4%COM NEWADBEAdobe$7,401,362$4,027,065 ▲119.3%19,2980.4%Computer and TechnologyKorro Bio Inc$7,291,8830.0%418,8330.4%COMNOWServiceNow$7,265,574$2,803,209 ▲62.8%9,1260.4%Computer and TechnologySEERSeer$6,760,0000.0%4,000,0000.4%MedicalPDDPDD$6,260,8330.0%52,9010.4%Retail/WholesaleSpyre Therapeutics Inc$5,947,329$87,161 ▼-1.4%368,5980.3%COM NEWGOSSGossamer Bio$5,729,865$227,700 ▼-3.8%5,208,9680.3%MedicalORICORIC Pharmaceuticals$5,622,2690.0%1,007,5750.3%MedicalUpstream Bio Inc$4,825,314$70,686 ▼-1.4%788,4500.3%COMNVDANVIDIA$4,815,540$487,710 ▼-9.2%44,4320.3%Computer and TechnologyTSMTaiwan Semiconductor Manufacturing$4,731,000$2,241,000 ▲90.0%28,5000.3%Computer and TechnologyDDOGDatadog$4,705,034$1,686,570 ▲55.9%47,4250.3%Computer and TechnologyNeumora Therapeutics Inc$4,358,283$37,817 ▼-0.9%4,358,2830.2%COMFROGJFrog$4,211,712$368,000 ▲9.6%131,6160.2%Computer and TechnologyDTDynatrace$4,136,422$235,750 ▲6.0%87,7290.2%Computer and TechnologyMetsera Inc$4,083,000$4,083,000 ▲New Holding150,0000.2%COMRCKTRocket Pharmaceuticals$3,943,724$58,276 ▼-1.5%591,2630.2%MedicalCRMSalesforce$3,918,056$3,918,056 ▲New Holding14,6000.2%Computer and TechnologyEDUNew Oriental Education & Technology Group$3,800,895$525,910 ▲16.1%79,5000.2%Consumer DiscretionaryRapport Therapeutics Inc$3,796,044$57,452 ▼-1.5%378,4690.2%COMIONQIonQ$3,751,9000.0%170,0000.2%Computer and TechnologyIGMSIGM Biosciences$3,744,200$85,785 ▼-2.2%3,255,8260.2%MedicalAADIAadi Bioscience$3,705,960$3,705,960 ▲New Holding2,082,0000.2%MedicalInstil Bio Inc$3,540,277$199,640 ▲6.0%203,9330.2%COM NEWTNGXTango Therapeutics$3,514,519$52,820 ▼-1.5%2,565,3420.2%MedicalVIGLVigil Neuroscience$3,501,374$42,674 ▼-1.2%1,967,0640.2%MedicalSionna Therapeutics Inc$3,399,500$3,399,500 ▲New Holding325,0000.2%COMYNDXYandex$2,955,400$422,200 ▲16.7%140,0000.2%Computer and TechnologyFHTXFoghorn Therapeutics$2,630,6280.0%720,7200.1%MedicalReddit Inc$2,465,150$2,465,150 ▲New Holding23,5000.1%CL ALPLALPL Financial$2,453,550$2,453,550 ▲New Holding7,5000.1%FinanceSagimet Biosciences Inc$2,362,7530.0%724,7710.1%COM SER AELDNEledon Pharmaceuticals$2,339,676$2,339,676 ▲New Holding690,1700.1%MedicalTSLATesla$2,332,440$2,332,440 ▲New Holding9,0000.1%Auto/Tires/TrucksKalaris Therapeutics Inc$2,269,166$2,269,166 ▲New Holding282,5860.1%COMMRVLMarvell Technology$2,266,269$1,958,419 ▲636.2%36,8080.1%Computer and TechnologyQCOMQUALCOMM$2,150,540$153,610 ▼-6.7%14,0000.1%Computer and TechnologyBEKEKE$2,109,450$904,050 ▲75.0%105,0000.1%Computer and TechnologyLexeo Therapeutics Inc$2,093,9190.0%603,4350.1%COMPRQRProQR Therapeutics$2,064,403$30,347 ▼-1.4%1,552,1830.1%MedicalPANWPalo Alto Networks$1,962,360$938,520 ▲91.7%11,5000.1%Computer and TechnologySailPoint Inc$1,781,250$1,781,250 ▲New Holding95,0000.1%COMBDTXBlack Diamond Therapeutics$1,622,1010.0%1,046,5170.1%MedicalLXRXLexicon Pharmaceuticals$1,620,271$16,313,555 ▼-91.0%3,516,2140.1%MedicalStandardAero, Inc.$1,514,617$1,514,617 ▲New Holding56,8550.1%COMBIOAGE Labs Inc$1,437,847$21,033 ▼-1.4%382,4060.1%COMTourmaline Bio Inc$1,390,5890.0%91,4260.1%COMWKWorkiva$1,328,425$569,325 ▲75.0%17,5000.1%Computer and TechnologyBILLBILL$1,307,865$1,307,865 ▲New Holding28,5000.1%Computer and TechnologyPYPLPayPal$1,305,000$326,250 ▲33.3%20,0000.1%Computer and TechnologyGBIOGeneration Bio$1,202,415$5,592 ▼-0.5%2,968,9250.1%MedicalSEMRSemrush$1,166,250$839,700 ▲257.1%125,0000.1%Computer and TechnologyPEGAPegasystems$1,147,080$1,147,080 ▲New Holding16,5000.1%Computer and TechnologyMDBMongoDB$964,700$964,700 ▲New Holding5,5000.1%Computer and TechnologyNKENIKE$952,200$952,200 ▲New Holding15,0000.1%Consumer DiscretionaryShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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