Siren, L.L.C. Top Holdings and 13F Report (2025) About Siren, L.L.C.Investment ActivitySiren, L.L.C. has $1.93 billion in total holdings as of June 30, 2025.Siren, L.L.C. owns shares of 110 different stocks, but just 31 companies or ETFs make up 80% of its holdings.Approximately 10.79% of the portfolio was purchased this quarter.About 11.46% of the portfolio was sold this quarter.This quarter, Siren, L.L.C. has purchased 116 new stocks and bought additional shares in 21 stocks.Siren, L.L.C. sold shares of 19 stocks and completely divested from 21 stocks this quarter.Largest Holdings Scholar Rock $327,635,177Kymera Therapeutics $149,604,466BeiGene $123,453,279Disc Medicine $58,224,277Crinetics Pharmaceuticals $48,564,452 Largest New Holdings this Quarter 61559X104 - MoonLake Immunotherapeutics $23,990,202 Holding00973Y108 - Akero Therapeutics $17,003,004 Holding04272N102 - Arrivent Biopharma Inc $15,239,000 Holding19240Q201 - Cogent Biosciences $6,134,441 Holding695127100 - Pacira BioSciences $5,377,500 Holding Largest Purchases this Quarter MoonLake Immunotherapeutics 508,267 shares (about $23.99M)Dyne Therapeutics Inc 2,118,450 shares (about $20.17M)Edgewise Therapeutics 1,463,854 shares (about $19.19M)Bicara Therapeutics Inc 1,949,886 shares (about $18.11M)Akero Therapeutics 318,647 shares (about $17.00M) Largest Sales this Quarter Soleno Therapeutics 259,995 shares (about $21.78M)NewAmsterdam Pharma 717,790 shares (about $13.00M)Vigil Neuroscience 1,555,873 shares (about $12.37M)Vera Therapeutics 500,000 shares (about $11.78M)Merus 190,000 shares (about $9.99M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSiren, L.L.C. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorSRRKScholar Rock$327,635,1770.0%9,250,00517.0%MedicalKYMRKymera Therapeutics$149,604,466$8,197,207 ▲5.8%3,428,1507.7%MedicalBGNEBeiGene$123,453,279$2,735,633 ▲2.3%509,9906.4%MedicalIRONDisc Medicine$58,224,277$1,458,307 ▲2.6%1,099,4013.0%MedicalCRNXCrinetics Pharmaceuticals$48,564,4520.0%1,688,6112.5%MedicalBicara Therapeutics Inc$48,465,642$18,114,441 ▲59.7%5,216,9692.5%COMDyne Therapeutics Inc$46,042,880$20,167,644 ▲77.9%4,836,4372.4%COMCNTACentessa Pharmaceuticals$45,464,781$6,570,000 ▲16.9%3,460,0292.4%MedicalMRUSMerus$44,892,364$9,994,000 ▼-18.2%853,4672.3%MedicalAPLSApellis Pharmaceuticals$44,632,0350.0%2,578,3962.3%MedicalASNDAscendis Pharma A/S$42,449,762$7,149,610 ▼-14.4%245,9432.2%MedicalARWRArrowhead Pharmaceuticals$42,184,1040.0%2,669,8802.2%MedicalEWTXEdgewise Therapeutics$41,431,507$19,191,126 ▲86.3%3,160,2982.1%MedicalSLNOSoleno Therapeutics$39,153,913$21,782,381 ▼-35.7%467,3422.0%MedicalLXRXLexicon Pharmaceuticals$36,805,6070.0%38,918,9031.9%MedicalTBLATaboola.com$36,488,3520.0%9,969,4951.9%Computer and TechnologySLDBSolid Biosciences$36,115,4570.0%7,415,9051.9%MedicalRVMDRevolution Medicines$34,536,796$13,796,250 ▲66.5%938,7551.8%MedicalRNAAvidity Biosciences$31,541,3240.0%1,110,6101.6%MedicalRYTMRhythm Pharmaceuticals$25,891,597$8,354,287 ▲47.6%409,7421.3%MedicalApogee Therapeutics Inc$25,840,5890.0%594,9941.3%COMSTOKStoke Therapeutics$25,507,3880.0%2,247,3471.3%MedicalTSHATaysha Gene Therapies$25,444,042$10,395,000 ▲69.1%11,014,7371.3%MedicalXENEXenon Pharmaceuticals$25,439,419$2,504,000 ▲10.9%812,7611.3%MedicalWVEWAVE Life Sciences$24,026,0930.0%3,696,3221.2%MedicalMLTXMoonLake Immunotherapeutics$23,990,202$23,990,202 ▲New Holding508,2671.2%MedicalSepterna Inc$23,280,5730.0%2,202,5141.2%COMNAMSNewAmsterdam Pharma$21,627,686$12,999,177 ▼-37.5%1,194,2401.1%MedicalTRVITrevi Therapeutics$21,545,198$5,880,250 ▲37.5%3,938,7931.1%MedicalTNGXTango Therapeutics$17,227,848$4,093,297 ▲31.2%3,364,8140.9%MedicalAKROAkero Therapeutics$17,003,004$17,003,004 ▲New Holding318,6470.9%MedicalSLNSilence Therapeutics$16,886,340$705,309 ▲4.4%2,911,4380.9%MedicalArrivent Biopharma Inc$15,239,000$15,239,000 ▲New Holding700,0000.8%COMBCYCBicycle Therapeutics$13,988,626$1,390,000 ▲11.0%2,012,7520.7%MedicalRCUSArcus Biosciences$13,122,3070.0%1,612,0770.7%MedicalIHSIHS$13,107,8110.0%2,357,5200.7%Computer and TechnologyAMZNAmazon.com$12,395,5350.0%56,5000.6%Retail/WholesaleDNLIDenali Therapeutics$11,492,9670.0%821,5130.6%MedicalERASErasca$11,121,7060.0%8,757,2490.6%MedicalORICOric Pharmaceuticals$10,226,8860.0%1,007,5750.5%MedicalRemitly Global Inc$9,674,978$469,250 ▲5.1%515,4490.5%COMPCVXVaxcyte$9,608,1030.0%295,5430.5%MedicalCRWDCrowdStrike$9,422,235$3,310,515 ▼-26.0%18,5000.5%Computer and TechnologyCGEMCullinan Therapeutics$8,986,3770.0%1,193,4100.5%MedicalGOOGLAlphabet$8,933,8690.0%50,7030.5%Computer and TechnologyUpstream Bio Inc$8,657,1810.0%788,4500.4%COMSEERSeer$8,560,0000.0%4,000,0000.4%MedicalMSFTMicrosoft$8,033,172$6,143,014 ▼-43.3%16,1500.4%Computer and TechnologyNVDANVIDIA$7,897,130$877,318 ▲12.5%49,9850.4%Computer and TechnologyIONQIonQ$7,304,9000.0%170,0000.4%Computer and TechnologyTSMTaiwan Semiconductor Manufacturing$6,907,945$452,980 ▲7.0%30,5000.4%Computer and TechnologyGOSSGossamer Bio$6,407,0310.0%5,208,9680.3%MedicalCRMSalesforce$6,162,794$2,181,520 ▲54.8%22,6000.3%Computer and TechnologyCOGTCogent Biosciences$6,134,441$6,134,441 ▲New Holding854,3790.3%MedicalCartesian Therapeutics Inc$5,852,3960.0%563,2720.3%COM NEWVERAVera Therapeutics$5,824,409$11,780,000 ▼-66.9%247,2160.3%MedicalADBEAdobe$5,822,931$1,643,079 ▼-22.0%15,0510.3%Computer and TechnologySionna Therapeutics Inc$5,638,7500.0%325,0000.3%COMPDDPDD$5,536,6190.0%52,9010.3%Retail/WholesaleSagimet Biosciences Inc$5,522,7550.0%724,7710.3%COM SER ASpyre Therapeutics Inc$5,517,9120.0%368,5980.3%COM NEWPCRXPacira BioSciences$5,377,500$5,377,500 ▲New Holding225,0000.3%MedicalNOWServiceNow$5,269,938$4,112,320 ▼-43.8%5,1260.3%Computer and TechnologyKorro Bio Inc$5,231,2240.0%418,8330.3%COMDDOGDatadog$5,161,630$1,208,970 ▼-19.0%38,4250.3%Computer and TechnologyAgenus Inc$4,863,623$2,578,623 ▲112.9%1,064,2500.3%COM NEWFROGJFrog$4,700,250$1,075,060 ▼-18.6%107,1160.2%Computer and TechnologyRapport Therapeutics Inc$4,303,1930.0%378,4690.2%COMInstil Bio Inc$4,247,9240.0%203,9330.2%COM NEWDTDynatrace$4,153,393$690,125 ▼-14.2%75,2290.2%Computer and TechnologyAADIAadi Bioscience$3,893,3400.0%2,082,0000.2%MedicalEDUNew Oriental Education & Technology Group$3,884,400$404,625 ▼-9.4%72,0000.2%Consumer DiscretionaryIGMSIGM Biosciences$3,646,5250.0%3,255,8260.2%MedicalFHTXFoghorn Therapeutics$3,387,3840.0%720,7200.2%MedicalVIGLVigil Neuroscience$3,268,968$12,369,189 ▼-79.1%411,1910.2%MedicalNeumora Therapeutics Inc$3,195,9290.0%4,358,2830.2%COMPRQRProQR Therapeutics$3,166,4530.0%1,552,1830.2%MedicalYNDXYandex$2,821,830$4,924,370 ▼-63.6%51,0000.1%Computer and TechnologyBDTXBlack Diamond Therapeutics$2,595,3620.0%1,046,5170.1%MedicalLexeo Therapeutics Inc$2,425,8090.0%603,4350.1%COMPANWPalo Alto Networks$2,353,3600.0%11,5000.1%Computer and TechnologyQCOMQUALCOMM$2,229,6400.0%14,0000.1%Computer and TechnologyWKWorkiva$1,916,600$718,725 ▲60.0%28,0000.1%Computer and TechnologyELDNEledon Pharmaceuticals$1,870,3610.0%690,1700.1%MedicalBEKEKE$1,862,7000.0%105,0000.1%Computer and TechnologyHUBSHubSpot$1,669,890$1,669,890 ▲New Holding3,0000.1%Computer and TechnologyUNHUnitedHealth Group$1,583,560$1,583,560 ▲New Holding5,0760.1%MedicalBIOAGE Labs Inc$1,579,3370.0%382,4060.1%COMGTLBGitLab$1,578,850$1,578,850 ▲New Holding35,0000.1%Computer and TechnologyTourmaline Bio Inc$1,461,9020.0%91,4260.1%COMRCKTRocket Pharmaceuticals$1,448,5940.0%591,2630.1%MedicalTSLATesla$1,270,640$1,588,300 ▼-55.6%4,0000.1%Auto/Tires/TrucksBirkenstock Holding PLC$1,229,500$1,229,500 ▲New Holding25,0000.1%COM SHSSailPoint Inc$1,143,000$1,028,700 ▼-47.4%50,0000.1%COMSEMRSemrush$1,131,2500.0%125,0000.1%Computer and TechnologyPrimo Brands Corp$1,110,750$1,110,750 ▲New Holding37,5000.1%CLASS A COM SHSCLBTCellebrite DI$960,000$960,000 ▲New Holding60,0000.0%Computer and TechnologyGBIOGeneration Bio$950,3530.0%2,968,9250.0%MedicalKalaris Therapeutics Inc$754,5050.0%282,5860.0%COMHOOKIPA Pharma Inc$711,1330.0%566,6400.0%COM NEWShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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