Karyopharm Therapeutics (KPTI) Stock Chart & Stock Price History $4.39 -0.04 (-0.79%) As of 11:02 AM Eastern This is a fair market value price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Karyopharm Therapeutics Stock Price Performance The Karyopharm Therapeutics (KPTI) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has decreased 70.99%, with a year-to-date return of -56.68%. In the past month, the stock has decreased 26.87%, reflecting recent market activity. As of the latest close, Karyopharm Therapeutics traded at $4.43 with a market cap of $38.28 million and volume of 66,173 shares. Five years ago, the stock traded at a split-adjusted price of $249.00, representing a 98.23% decrease over that period. At the time, it had a market cap of $1.24 billion and a volume of 97,245 shares. Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Email Address 5 Day Performance-2.12%1 Month Performance-26.87%3 Month Performance-40.93%Year-To-Date Performance-56.68%1 Year Performance-70.99%5 Year Performance-98.23% KPTI Stock Chart for Wednesday, June, 11, 2025 KPTI Chart by TradingView Karyopharm Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization06/10/2025$4.21$4.43+5.23%$4.61$4.2266,173 shs$38.28 million06/09/2025$4.49$4.21-6.24%$4.62$4.1959,574 shs$36.37 million06/06/2025$4.26$4.49+5.40%$4.77$4.27139,734 shs$38.79 million06/05/2025$4.34$4.26-1.84%$4.39$4.2054,801 shs$36.81 million06/04/2025$4.25$4.34+2.12%$4.42$4.10116,172 shs$37.50 million06/03/2025$4.12$4.25+3.16%$4.33$4.0982,948 shs$36.72 million06/02/2025$4.30$4.12-4.19%$4.36$4.06109,551 shs$35.60 million05/30/2025$4.53$4.30-5.08%$4.65$4.15112,584 shs$37.15 million05/29/2025$4.48$4.53+1.12%$4.60$4.3589,685 shs$39.14 million05/28/2025$4.55$4.48-1.54%$4.68$4.3386,849 shs$38.71 million Get the Latest News and Ratings for KPTI and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 05/27/2025$4.59$4.55-0.87%$4.81$4.3699,040 shs$39.31 million05/26/2025$4.59$4.59$4.74$4.3464,571 shs$39.66 million05/23/2025$4.64$4.59-1.08%$4.74$4.3464,571 shs$39.66 million05/22/2025$4.70$4.64-1.28%$4.88$4.6064,015 shs$40.09 million05/21/2025$5.16$4.70-8.91%$5.11$4.6180,381 shs$40.61 million05/20/2025$5.13$5.16+0.58%$5.30$5.0241,486 shs$44.58 million05/19/2025$5.32$5.13-3.57%$5.30$4.8458,354 shs$44.32 million05/16/2025$5.44$5.32-2.21%$5.64$5.2535,974 shs$45.59 million05/15/2025$4.85$5.44+12.16%$5.48$4.85108,997 shs$46.62 million05/14/2025$4.92$4.85-1.42%$5.22$4.6471,800 shs$41.56 million05/13/2025$6.15$4.92-20.00%$5.96$4.75265,471 shs$42.16 million05/12/2025$6.01$6.15+2.33%$6.22$5.6055,261 shs$52.71 million Related Companies Eupraxia Pharmaceuticals Stock Chart Larimar Therapeutics Stock Chart FitLife Brands Stock Chart Alector Stock Chart TuHURA Biosciences Stock Chart Black Diamond Therapeutics Stock Chart Enanta Pharmaceuticals Stock Chart Compugen Stock Chart Greenwich LifeSciences Stock Chart Protara Therapeutics Stock Chart Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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