Karyopharm Therapeutics (KPTI) Stock Chart & Stock Price History $6.34 +0.15 (+2.42%) Closing price 04:00 PM EasternExtended Trading$6.30 -0.04 (-0.65%) As of 07:57 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Karyopharm Therapeutics Stock Price Performance The Karyopharm Therapeutics (KPTI) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has decreased 48.20%, with a year-to-date return of -37.50%. In the past month, the stock has decreased 7.85%, reflecting recent market activity. As of the latest close, Karyopharm Therapeutics traded at $6.19 with a market cap of $53.67 million and volume of 90,164 shares. Five years ago, the stock traded at a split-adjusted price of $236.40, representing a 97.32% decrease over that period. At the time, it had a market cap of $1.16 billion and a volume of 40,436 shares. Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. 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Read our full terms of service and privacy policy. 5 Day Performance+6.91%1 Month Performance-7.85%3 Month Performance+43.12%Year-To-Date Performance-37.50%1 Year Performance-48.20%5 Year Performance-97.32% KPTI Stock Chart for Friday, October, 24, 2025 KPTI Chart by TradingView Karyopharm Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization10/24/2025$6.19$6.34+2.42%$6.39$6.1184,549 shs$54.97 million10/23/2025$6.14$6.19+0.81%$6.40$6.1490,164 shs$53.67 million10/22/2025$6.43$6.14-4.51%$6.75$5.71331,435 shs$53.24 million10/21/2025$6.47$6.43-0.62%$6.60$6.1883,025 shs$55.75 million10/20/2025$5.93$6.47+9.11%$6.70$5.93248,256 shs$56.10 million10/17/2025$6.03$5.93-1.66%$6.03$5.7649,883 shs$51.41 million10/16/2025$5.95$6.03+1.34%$6.07$5.84151,380 shs$52.28 million10/15/2025$5.77$5.95+3.12%$6.22$5.85179,312 shs$51.59 million10/14/2025$5.62$5.77+2.67%$6.06$5.51207,168 shs$50.03 million10/13/2025$5.50$5.62+2.18%$6.15$5.60171,702 shs$48.73 million10/10/2025$5.82$5.50-5.50%$5.95$5.50217,715 shs$47.69 million10/09/2025$5.90$5.82-1.36%$6.09$5.52649,781 shs$51.16 million10/08/2025$5.77$5.90+2.25%$6.11$4.513.13 million shs$51.15 million10/07/2025$6.16$5.77-6.33%$6.29$5.52133,887 shs$50.03 million10/06/2025$6.38$6.16-3.45%$6.68$6.1551,798 shs$53.41 million10/03/2025$6.29$6.38+1.43%$6.59$6.1947,255 shs$55.32 million10/02/2025$6.21$6.29+1.29%$6.45$6.1735,792 shs$54.53 million10/01/2025$6.54$6.21-5.05%$6.70$6.1369,309 shs$53.84 million09/30/2025$6.35$6.54+2.99%$6.62$6.0844,367 shs$56.71 million09/29/2025$6.55$6.35-3.05%$6.77$6.3355,578 shs$55.05 million09/26/2025$6.66$6.55-1.65%$6.64$6.2848,568 shs$56.79 million09/25/2025$6.88$6.66-3.20%$7.18$6.6639,978 shs$57.74 million09/24/2025$7.48$6.88-8.02%$7.90$6.80145,889 shs$59.66 million09/23/2025$5.85$7.48+27.86%$7.89$5.64474,027 shs$64.85 million Related Companies Corbus Pharmaceuticals Stock Chart Forte Biosciences Stock Chart Journey Medical Stock Chart Fate Therapeutics Stock Chart Protalix BioTherapeutics Stock Chart Innate Pharma Stock Chart Tonix Pharmaceuticals Stock Chart FitLife Brands Stock Chart Avalo Therapeutics Stock Chart BioHarvest Sciences Stock Chart Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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