Karyopharm Therapeutics (KPTI) Stock Chart & Stock Price History $5.90 +0.13 (+2.25%) Closing price 10/8/2025 04:00 PM EasternExtended Trading$5.63 -0.27 (-4.58%) As of 09:16 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Karyopharm Therapeutics Stock Price Performance The Karyopharm Therapeutics (KPTI) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has decreased 53.97%, with a year-to-date return of -41.84%. In the past month, the stock has decreased 6.79%, reflecting recent market activity. As of the latest close, Karyopharm Therapeutics traded at $5.90 with a market cap of $51.15 million and volume of 3.13 million shares. Five years ago, the stock traded at a split-adjusted price of $222.45, representing a 97.35% decrease over that period. At the time, it had a market cap of $1.09 billion and a volume of 76,104 shares. Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. 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Read our full terms of service and privacy policy. 5 Day Performance-7.52%1 Month Performance-6.79%3 Month Performance+22.66%Year-To-Date Performance-41.84%1 Year Performance-53.97%5 Year Performance-97.35% KPTI Stock Chart for Thursday, October, 9, 2025 KPTI Chart by TradingView Karyopharm Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization10/08/2025$5.77$5.90+2.25%$6.11$4.513.13 million shs$51.15 million10/07/2025$6.16$5.77-6.33%$6.29$5.52133,887 shs$50.03 million10/06/2025$6.38$6.16-3.45%$6.68$6.1551,798 shs$53.41 million10/03/2025$6.29$6.38+1.43%$6.59$6.1947,255 shs$55.32 million10/02/2025$6.21$6.29+1.29%$6.45$6.1735,792 shs$54.53 million10/01/2025$6.54$6.21-5.05%$6.70$6.1369,309 shs$53.84 million09/30/2025$6.35$6.54+2.99%$6.62$6.0844,367 shs$56.71 million09/29/2025$6.55$6.35-3.05%$6.77$6.3355,578 shs$55.05 million09/26/2025$6.66$6.55-1.65%$6.64$6.2848,568 shs$56.79 million09/25/2025$6.88$6.66-3.20%$7.18$6.6639,978 shs$57.74 million Get the Latest News and Ratings for KPTI and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 09/24/2025$7.48$6.88-8.02%$7.90$6.80145,889 shs$59.66 million09/23/2025$5.85$7.48+27.86%$7.89$5.64474,027 shs$64.85 million09/22/2025$5.41$5.85+8.13%$5.92$5.32149,588 shs$50.72 million09/19/2025$5.73$5.41-5.58%$5.84$5.33173,955 shs$46.91 million09/18/2025$6.08$5.73-5.76%$6.15$5.6871,583 shs$49.69 million09/17/2025$6.26$6.08-2.88%$6.40$6.0251,041 shs$52.71 million09/16/2025$6.26$6.26$6.40$6.1627,108 shs$54.27 million09/15/2025$6.45$6.26-2.95%$6.78$6.1562,709 shs$54.28 million09/12/2025$6.64$6.45-2.86%$6.85$6.3965,890 shs$55.93 million09/11/2025$6.21$6.64+6.92%$6.64$6.1946,118 shs$57.57 million09/10/2025$6.33$6.21-1.90%$6.60$6.1979,538 shs$53.84 million09/09/2025$6.25$6.33+1.28%$6.89$6.2045,027 shs$54.89 million09/08/2025$6.60$6.25-5.30%$6.54$5.70164,034 shs$54.19 million Related Companies Organigram Global Stock Chart ProQR Therapeutics Stock Chart Heron Therapeutics Stock Chart Entrada Therapeutics Stock Chart Cabaletta Bio Stock Chart Aclaris Therapeutics Stock Chart Ventyx Biosciences Stock Chart Tonix Pharmaceuticals Stock Chart Eupraxia Pharmaceuticals Stock Chart Scilex Stock Chart Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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