Karyopharm Therapeutics (KPTI) Stock Chart & Stock Price History $4.70 -0.46 (-8.91%) Closing price 05/21/2025 04:00 PM EasternExtended Trading$4.72 +0.02 (+0.43%) As of 05/21/2025 06:36 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Karyopharm Therapeutics Stock Price Performance The Karyopharm Therapeutics (KPTI) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has decreased 71.77%, with a year-to-date return of -53.67%. In the past month, the stock has decreased 22.06%, reflecting recent market activity. As of the latest close, Karyopharm Therapeutics traded at $4.70 with a market cap of $40.61 million and volume of 80,381 shares. Five years ago, the stock traded at a split-adjusted price of $309.75, representing a 98.48% decrease over that period. At the time, it had a market cap of $1.40 billion and a volume of 135,742 shares. Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Email Address 5 Day Performance-11.65%1 Month Performance-22.06%3 Month Performance-47.64%Year-To-Date Performance-53.67%1 Year Performance-71.77%5 Year Performance-98.48% KPTI Stock Chart for Thursday, May, 22, 2025 KPTI Chart by TradingView Karyopharm Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame * Start Date * End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization05/21/2025$5.16$4.70-8.91%$5.11$4.6180,381 shs$40.61 million05/20/2025$5.13$5.16+0.58%$5.30$5.0241,486 shs$44.58 million05/19/2025$5.32$5.13-3.57%$5.30$4.8458,354 shs$44.32 million05/16/2025$5.44$5.32-2.21%$5.64$5.2535,974 shs$45.59 million05/15/2025$4.85$5.44+12.16%$5.48$4.85108,997 shs$46.62 million05/14/2025$4.92$4.85-1.42%$5.22$4.6471,800 shs$41.56 million05/13/2025$6.15$4.92-20.00%$5.96$4.75265,471 shs$42.16 million05/12/2025$6.01$6.15+2.33%$6.22$5.6055,261 shs$52.71 million05/09/2025$6.15$6.01-2.28%$6.71$5.8162,645 shs$51.51 million05/08/2025$6.11$6.15+0.65%$6.31$5.9070,580 shs$52.71 million Get the Latest News and Ratings for KPTI and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 05/07/2025$6.27$6.11-2.55%$6.43$6.0135,534 shs$52.36 million05/06/2025$7.09$6.27-11.57%$7.42$6.0494,987 shs$53.73 million05/05/2025$7.36$7.09-3.67%$7.83$7.04107,138 shs$60.76 million05/02/2025$6.76$7.36+8.88%$7.90$6.73120,197 shs$63.08 million05/01/2025$6.75$6.76+0.15%$6.99$6.4054,408 shs$57.93 million04/30/2025$6.35$6.75+6.30%$6.79$6.2581,516 shs$57.85 million04/29/2025$6.07$6.35+4.61%$6.41$5.9451,875 shs$54.42 million04/28/2025$5.62$6.07+8.01%$6.32$5.52133,530 shs$52.02 million04/25/2025$5.97$5.62-5.86%$5.86$5.5250,896 shs$48.16 million04/24/2025$6.27$5.97-4.78%$6.46$5.78115,921 shs$51.16 million04/23/2025$6.03$6.27+3.98%$6.56$6.09100,115 shs$53.73 million04/22/2025$5.40$6.03+11.67%$6.08$5.39107,837 shs$51.68 million04/21/2025$4.95$5.40+9.09%$5.50$4.8981,398 shs$46.28 million Related Companies Design Therapeutics Stock Chart Humacyte Stock Chart Ocugen Stock Chart Actuate Therapeutics Stock Chart MediWound Stock Chart Nuvectis Pharma Stock Chart Annexon Stock Chart Innate Pharma Stock Chart CARGO Therapeutics Stock Chart Voyager Therapeutics Stock Chart Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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