Karyopharm Therapeutics (KPTI) Stock Chart & Stock Price History $6.30 +0.28 (+4.65%) Closing price 04:00 PM EasternExtended Trading$6.30 0.00 (0.00%) As of 05:58 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Karyopharm Therapeutics Stock Price Performance The Karyopharm Therapeutics (KPTI) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has decreased 46.65%, with a year-to-date return of -37.90%. In the past month, the stock has increased 61.95%, reflecting recent market activity. As of the latest close, Karyopharm Therapeutics traded at $6.02 with a market cap of $52.19 million and volume of 88,331 shares. Five years ago, the stock traded at a split-adjusted price of $213.00, representing a 97.04% decrease over that period. At the time, it had a market cap of $1.09 billion and a volume of 79,855 shares. Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Email Address 5 Day Performance+6.42%1 Month Performance+61.95%3 Month Performance+35.78%Year-To-Date Performance-37.90%1 Year Performance-46.65%5 Year Performance-97.04% KPTI Stock Chart for Friday, August, 22, 2025 KPTI Chart by TradingView Karyopharm Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization08/21/2025$6.50$6.02-7.38%$6.68$6.0288,331 shs$52.19 million08/20/2025$6.22$6.50+4.50%$7.01$6.14313,071 shs$56.36 million08/19/2025$5.59$6.22+11.27%$6.40$5.49135,787 shs$53.93 million08/18/2025$5.92$5.59-5.57%$5.89$5.50124,675 shs$48.47 million08/15/2025$4.65$5.92+27.31%$6.90$4.671.62 million shs$51.33 million08/14/2025$4.45$4.65+4.49%$4.72$4.31154,872 shs$40.32 million08/13/2025$4.02$4.45+10.70%$4.60$4.01144,585 shs$38.45 million08/12/2025$3.77$4.02+6.63%$4.16$3.74183,556 shs$34.73 million08/11/2025$3.94$3.77-4.31%$4.01$3.65301,151 shs$32.57 million08/08/2025$3.97$3.94-0.76%$4.07$3.8390,784 shs$34.04 million Get the Latest News and Ratings for KPTI and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 08/07/2025$4.03$3.97-1.49%$4.35$3.87211,424 shs$34.30 million08/06/2025$3.88$4.03+3.87%$4.15$3.81103,916 shs$34.82 million08/05/2025$4.02$3.88-3.48%$4.17$3.85108,931 shs$33.52 million08/04/2025$3.93$4.02+2.29%$4.08$3.8328,589 shs$34.73 million08/01/2025$3.81$3.93+3.15%$4.04$3.7164,132 shs$33.96 million07/31/2025$4.05$3.81-5.93%$4.09$3.75116,504 shs$32.92 million07/30/2025$4.13$4.05-1.94%$4.36$4.0043,722 shs$34.99 million07/29/2025$4.37$4.13-5.49%$4.39$4.0086,560 shs$35.68 million07/28/2025$4.35$4.37+0.46%$4.45$4.2250,746 shs$37.76 million07/25/2025$4.43$4.35-1.81%$4.60$4.3548,391 shs$37.58 million07/24/2025$4.86$4.43-8.85%$4.91$4.37210,024 shs$38.28 million07/23/2025$3.89$4.86+24.94%$4.90$3.84608,578 shs$41.99 million07/22/2025$4.02$3.89-3.23%$4.07$3.85152,743 shs$33.61 million07/21/2025$3.85$4.02+4.42%$4.20$3.89105,113 shs$34.73 million Related Companies Heron Therapeutics Stock Chart Lyell Immunopharma Stock Chart Aclaris Therapeutics Stock Chart Innate Pharma Stock Chart Ventyx Biosciences Stock Chart Entrada Therapeutics Stock Chart GENFIT Stock Chart MediWound Stock Chart Rapt Therapeutics Stock Chart Neoleukin Therapeutics Stock Chart Receive KPTI Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Karyopharm Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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