Upstream Bio (UPB) Stock Chart & Stock Price History $16.76 +0.06 (+0.36%) Closing price 08/28/2025 04:00 PM EasternExtended Trading$16.75 -0.01 (-0.06%) As of 08/28/2025 04:11 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOwnershipSEC FilingsTrendsBuy This Stock Upstream Bio Stock Price Performance The Upstream Bio (UPB) stock chart highlights key performance trends across multiple timeframes. Since the beginning of the year, the stock increased 1.95%. In the past month, the stock has increased 19.97%, reflecting recent market activity. As of the latest close, Upstream Bio traded at $16.76 with a market cap of $903.53 million and volume of 444,386 shares. 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Read our full terms of service and privacy policy. 5 Day Performance-4.93%1 Month Performance+19.97%3 Month Performance+79.25%Year-To-Date Performance+1.95% UPB Stock Chart for Friday, August, 29, 2025 UPB Chart by TradingView Upstream Bio Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization08/28/2025$16.70$16.76+0.36%$17.20$16.42444,386 shs$903.53 million08/27/2025$17.30$16.70-3.47%$17.42$16.66254,173 shs$900.28 million08/26/2025$16.73$17.30+3.41%$17.78$16.93356,186 shs$932.64 million08/25/2025$17.63$16.73-5.10%$17.60$16.56215,747 shs$901.91 million08/22/2025$17.74$17.63-0.62%$18.48$17.54289,080 shs$950.43 million08/21/2025$16.36$17.74+8.44%$17.98$16.02421,874 shs$956.36 million08/20/2025$16.90$16.36-3.20%$17.17$16.34378,945 shs$881.97 million08/19/2025$18.02$16.90-6.22%$18.23$16.50507,894 shs$911.08 million08/18/2025$18.93$18.02-4.81%$19.37$17.67394,799 shs$971.46 million08/15/2025$18.62$18.93+1.66%$19.28$18.15424,802 shs$1.02 billion Get the Latest News and Ratings for UPB and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Upstream Bio and its competitors with MarketBeat's FREE daily newsletter. 08/14/2025$18.56$18.62+0.32%$18.95$16.80525,569 shs$1.00 billion08/13/2025$17.50$18.56+6.06%$18.70$17.05557,831 shs$1.00 billion08/12/2025$16.59$17.50+5.49%$17.82$16.62290,401 shs$943.43 million08/11/2025$16.00$16.59+3.69%$16.62$15.641.45 million shs$892.44 million08/08/2025$15.84$16.00+1.01%$16.00$15.18214,758 shs$860.70 million08/07/2025$16.72$15.84-5.26%$17.57$15.81371,732 shs$852.03 million08/06/2025$15.50$16.72+7.87%$16.80$15.05366,682 shs$899.37 million08/05/2025$15.61$15.50-0.70%$16.06$15.45359,635 shs$833.81 million08/04/2025$15.54$15.61+0.45%$15.88$15.04410,281 shs$839.66 million08/01/2025$15.31$15.54+1.50%$15.60$14.21514,108 shs$835.90 million07/31/2025$15.19$15.31+0.79%$16.15$15.02567,996 shs$823.53 million07/30/2025$13.97$15.19+8.73%$15.47$13.99868,457 shs$817.13 million07/29/2025$14.34$13.97-2.58%$14.63$12.95469,205 shs$751.45 million07/28/2025$13.63$14.34+5.21%$15.27$13.59760,548 shs$771.35 million Related Companies PTGX Stock Price Chart APLS Stock Price Chart MLTX Stock Price Chart MIRM Stock Price Chart MTSR Stock Price Chart MENS Stock Price Chart KYMR Stock Price Chart SRRK Stock Price Chart AMRX Stock Price Chart BHC Stock Price Chart Receive UPB Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Upstream Bio and its competitors with MarketBeat's FREE daily newsletter. 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