Upstream Bio (UPB) Stock Chart & Stock Price History $18.92 +0.25 (+1.34%) Closing price 10/8/2025 04:00 PM EasternExtended Trading$19.01 +0.09 (+0.48%) As of 04:27 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOwnershipSEC FilingsShort InterestTrendsBuy This Stock Upstream Bio Stock Price Performance The Upstream Bio (UPB) stock chart highlights key performance trends across multiple timeframes. Since the beginning of the year, the stock increased 15.09%. In the past month, the stock has increased 3.73%, reflecting recent market activity. As of the latest close, Upstream Bio traded at $18.92 with a market cap of $1.02 billion and volume of 328,407 shares. 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Read our full terms of service and privacy policy. 5 Day Performance+1.56%1 Month Performance+3.73%3 Month Performance+61.71%Year-To-Date Performance+15.09% UPB Stock Chart for Thursday, October, 9, 2025 UPB Chart by TradingView Upstream Bio Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization10/08/2025$18.67$18.92+1.34%$19.30$18.72328,407 shs$1.02 billion10/07/2025$18.97$18.67-1.58%$18.96$18.17190,145 shs$1.01 billion10/06/2025$18.63$18.97+1.83%$19.44$18.72334,578 shs$1.02 billion10/03/2025$18.59$18.63+0.22%$19.06$18.60239,517 shs$1.00 billion10/02/2025$18.63$18.59-0.21%$19.01$18.37336,949 shs$1.00 billion10/01/2025$18.81$18.63-0.96%$19.00$18.05327,760 shs$1.00 billion09/30/2025$17.34$18.81+8.48%$19.23$17.14783,041 shs$1.01 billion09/29/2025$17.26$17.34+0.46%$17.81$17.06208,388 shs$934.80 million09/26/2025$16.31$17.26+5.82%$17.32$16.27254,348 shs$930.49 million09/25/2025$16.75$16.31-2.63%$16.63$16.02171,304 shs$879.27 million Get the Latest News and Ratings for UPB and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Upstream Bio and its competitors with MarketBeat's FREE daily newsletter. 09/24/2025$16.28$16.75+2.89%$16.78$16.20294,685 shs$902.98 million09/23/2025$16.65$16.28-2.22%$16.79$16.14190,419 shs$877.66 million09/22/2025$16.38$16.65+1.65%$16.98$16.00322,092 shs$897.60 million09/19/2025$17.27$16.38-5.15%$17.59$16.162.45 million shs$883.05 million09/18/2025$16.02$17.27+7.80%$17.40$16.16342,799 shs$931.01 million09/17/2025$17.35$16.02-7.67%$17.78$15.55539,363 shs$863.64 million09/16/2025$16.79$17.35+3.34%$17.97$16.61593,399 shs$935.34 million09/15/2025$17.57$16.79-4.44%$18.00$16.79373,978 shs$905.13 million09/12/2025$17.92$17.57-1.95%$18.11$17.54282,430 shs$947.20 million09/11/2025$17.80$17.92+0.67%$18.18$17.47305,341 shs$966.07 million09/10/2025$18.24$17.80-2.41%$18.71$17.02526,200 shs$959.60 million09/09/2025$18.73$18.24-2.62%$18.94$17.98373,667 shs$983.32 million09/08/2025$19.97$18.73-6.21%$20.32$18.67600,169 shs$1.01 billion Related Companies CRNX Stock Price Chart ZLAB Stock Price Chart MIRM Stock Price Chart AKRO Stock Price Chart AAPG Stock Price Chart SRRK Stock Price Chart ACAD Stock Price Chart ADMA Stock Price Chart LNTH Stock Price Chart MENS Stock Price Chart Receive UPB Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Upstream Bio and its competitors with MarketBeat's FREE daily newsletter. 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