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Xilio Therapeutics (XLO) Competitors

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$8.93 0.00 (0.00%)
Closing price 09/11/2026 04:00 PM Eastern
Extended Trading
$9.09 +0.16 (+1.74%)
As of 09/11/2026 06:59 PM Eastern
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XLO vs. ADAG, GLSI, TARA, IPHA, and ABOS

Should you buy Xilio Therapeutics stock or one of its competitors? Xilio Therapeutics's main competitors and comparable companies include Adagene (ADAG), Greenwich LifeSciences (GLSI), Protara Therapeutics (TARA), Innate Pharma (IPHA), and Acumen Pharmaceuticals (ABOS). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Xilio Therapeutics compare to Adagene?

Xilio Therapeutics (NASDAQ:XLO) and Adagene (NASDAQ:ADAG) are both small-cap healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their dividends, analyst recommendations, institutional ownership, risk, media sentiment, profitability, earnings and valuation.

In the previous week, Adagene had 9 more articles in the media than Xilio Therapeutics. MarketBeat recorded 10 mentions for Adagene and 1 mentions for Xilio Therapeutics. Xilio Therapeutics' average media sentiment score of 1.87 beat Adagene's score of 0.31 indicating that Xilio Therapeutics is being referred to more favorably in the media.

Company Overall Sentiment
Xilio Therapeutics Very Positive
Adagene Neutral

Xilio Therapeutics has a beta of -0.14, suggesting that its share price is 114% less volatile than the broader market. Comparatively, Adagene has a beta of 0.56, suggesting that its share price is 44% less volatile than the broader market.

54.3% of Xilio Therapeutics shares are owned by institutional investors. Comparatively, 9.5% of Adagene shares are owned by institutional investors. 7.5% of Xilio Therapeutics shares are owned by insiders. Comparatively, 21.2% of Adagene shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Adagene has a consensus target price of $9.50, indicating a potential upside of 179.41%. Given Adagene's stronger consensus rating and higher possible upside, analysts plainly believe Adagene is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00
Adagene
1 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
1 Strong Buy rating(s)
2.75

Adagene has a net margin of 0.00% compared to Xilio Therapeutics' net margin of -34.06%. Adagene's return on equity of 0.00% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Xilio Therapeutics-34.06% -71.99% -20.43%
Adagene N/A N/A N/A

Adagene has lower revenue, but higher earnings than Xilio Therapeutics.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xilio Therapeutics$43.77M1.34-$35.04M-$1.64N/A
Adagene$7.67M29.28-$17.61MN/AN/A

Summary

Adagene beats Xilio Therapeutics on 12 of the 15 factors compared between the two stocks.

How does Xilio Therapeutics compare to Greenwich LifeSciences?

Greenwich LifeSciences (NASDAQ:GLSI) and Xilio Therapeutics (NASDAQ:XLO) are both small-cap healthcare companies, but which is the superior stock? We will contrast the two companies based on the strength of their dividends, earnings, valuation, risk, profitability, institutional ownership, analyst recommendations and media sentiment.

Greenwich LifeSciences has higher earnings, but lower revenue than Xilio Therapeutics. Greenwich LifeSciences is trading at a lower price-to-earnings ratio than Xilio Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Greenwich LifeSciencesN/AN/A-$19.36M-$1.54N/A
Xilio Therapeutics$43.77M1.34-$35.04M-$1.64N/A

In the previous week, Greenwich LifeSciences and Greenwich LifeSciences both had 1 articles in the media. Greenwich LifeSciences' average media sentiment score of 1.89 beat Xilio Therapeutics' score of 1.87 indicating that Greenwich LifeSciences is being referred to more favorably in the media.

Company Overall Sentiment
Greenwich LifeSciences Very Positive
Xilio Therapeutics Very Positive

4.2% of Greenwich LifeSciences shares are owned by institutional investors. Comparatively, 54.3% of Xilio Therapeutics shares are owned by institutional investors. 51.5% of Greenwich LifeSciences shares are owned by insiders. Comparatively, 7.5% of Xilio Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Greenwich LifeSciences currently has a consensus target price of $69.00, suggesting a potential upside of 346.60%. Given Greenwich LifeSciences' stronger consensus rating and higher probable upside, research analysts clearly believe Greenwich LifeSciences is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Greenwich LifeSciences
1 Sell rating(s)
0 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

Greenwich LifeSciences has a beta of 1.47, suggesting that its stock price is 47% more volatile than the broader market. Comparatively, Xilio Therapeutics has a beta of -0.14, suggesting that its stock price is 114% less volatile than the broader market.

Greenwich LifeSciences has a net margin of 0.00% compared to Xilio Therapeutics' net margin of -34.06%. Xilio Therapeutics' return on equity of -71.99% beat Greenwich LifeSciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Greenwich LifeSciencesN/A -793.81% -295.32%
Xilio Therapeutics -34.06%-71.99%-20.43%

Summary

Greenwich LifeSciences beats Xilio Therapeutics on 9 of the 13 factors compared between the two stocks.

How does Xilio Therapeutics compare to Protara Therapeutics?

Xilio Therapeutics (NASDAQ:XLO) and Protara Therapeutics (NASDAQ:TARA) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two companies based on the strength of their valuation, profitability, media sentiment, risk, institutional ownership, earnings, dividends and analyst recommendations.

Protara Therapeutics has a net margin of 0.00% compared to Xilio Therapeutics' net margin of -34.06%. Protara Therapeutics' return on equity of -41.72% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Xilio Therapeutics-34.06% -71.99% -20.43%
Protara Therapeutics N/A -41.72%-38.78%

Protara Therapeutics has a consensus target price of $26.25, suggesting a potential upside of 587.17%. Given Protara Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Protara Therapeutics is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00
Protara Therapeutics
1 Sell rating(s)
0 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.75

In the previous week, Protara Therapeutics had 1 more articles in the media than Xilio Therapeutics. MarketBeat recorded 2 mentions for Protara Therapeutics and 1 mentions for Xilio Therapeutics. Xilio Therapeutics' average media sentiment score of 1.87 beat Protara Therapeutics' score of 0.94 indicating that Xilio Therapeutics is being referred to more favorably in the media.

Company Overall Sentiment
Xilio Therapeutics Very Positive
Protara Therapeutics Positive

Xilio Therapeutics has higher revenue and earnings than Protara Therapeutics. Xilio Therapeutics is trading at a lower price-to-earnings ratio than Protara Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xilio Therapeutics$43.77M1.34-$35.04M-$1.64N/A
Protara TherapeuticsN/AN/A-$57.44M-$1.35N/A

Xilio Therapeutics has a beta of -0.14, indicating that its stock price is 114% less volatile than the broader market. Comparatively, Protara Therapeutics has a beta of 1.49, indicating that its stock price is 49% more volatile than the broader market.

54.3% of Xilio Therapeutics shares are held by institutional investors. Comparatively, 38.1% of Protara Therapeutics shares are held by institutional investors. 7.5% of Xilio Therapeutics shares are held by company insiders. Comparatively, 7.6% of Protara Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Summary

Protara Therapeutics beats Xilio Therapeutics on 9 of the 14 factors compared between the two stocks.

How does Xilio Therapeutics compare to Innate Pharma?

Xilio Therapeutics (NASDAQ:XLO) and Innate Pharma (NASDAQ:IPHA) are both small-cap healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their risk, earnings, valuation, institutional ownership, media sentiment, analyst recommendations, dividends and profitability.

Xilio Therapeutics has higher revenue and earnings than Innate Pharma.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xilio Therapeutics$43.77M1.34-$35.04M-$1.64N/A
Innate Pharma$10.19M20.50-$55.64MN/AN/A

Innate Pharma has a net margin of 0.00% compared to Xilio Therapeutics' net margin of -34.06%. Innate Pharma's return on equity of 0.00% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Xilio Therapeutics-34.06% -71.99% -20.43%
Innate Pharma N/A N/A N/A

54.3% of Xilio Therapeutics shares are held by institutional investors. Comparatively, 0.2% of Innate Pharma shares are held by institutional investors. 7.5% of Xilio Therapeutics shares are held by company insiders. Comparatively, 31.9% of Innate Pharma shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

In the previous week, Innate Pharma had 5 more articles in the media than Xilio Therapeutics. MarketBeat recorded 6 mentions for Innate Pharma and 1 mentions for Xilio Therapeutics. Xilio Therapeutics' average media sentiment score of 1.87 beat Innate Pharma's score of 0.81 indicating that Xilio Therapeutics is being referred to more favorably in the media.

Company Overall Sentiment
Xilio Therapeutics Very Positive
Innate Pharma Positive

Innate Pharma has a consensus price target of $6.67, indicating a potential upside of 256.51%. Given Innate Pharma's stronger consensus rating and higher possible upside, analysts clearly believe Innate Pharma is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00
Innate Pharma
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.67

Xilio Therapeutics has a beta of -0.14, suggesting that its stock price is 114% less volatile than the broader market. Comparatively, Innate Pharma has a beta of 0.34, suggesting that its stock price is 66% less volatile than the broader market.

Summary

Innate Pharma beats Xilio Therapeutics on 10 of the 14 factors compared between the two stocks.

How does Xilio Therapeutics compare to Acumen Pharmaceuticals?

Acumen Pharmaceuticals (NASDAQ:ABOS) and Xilio Therapeutics (NASDAQ:XLO) are both small-cap healthcare companies, but which is the superior business? We will contrast the two businesses based on the strength of their institutional ownership, media sentiment, risk, profitability, analyst recommendations, valuation, earnings and dividends.

Acumen Pharmaceuticals presently has a consensus target price of $8.00, indicating a potential upside of 173.97%. Given Acumen Pharmaceuticals' stronger consensus rating and higher probable upside, research analysts plainly believe Acumen Pharmaceuticals is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Acumen Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.33
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

Xilio Therapeutics has higher revenue and earnings than Acumen Pharmaceuticals. Xilio Therapeutics is trading at a lower price-to-earnings ratio than Acumen Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Acumen PharmaceuticalsN/AN/A-$121.33M-$1.63N/A
Xilio Therapeutics$43.77M1.34-$35.04M-$1.64N/A

Acumen Pharmaceuticals has a net margin of 0.00% compared to Xilio Therapeutics' net margin of -34.06%. Xilio Therapeutics' return on equity of -71.99% beat Acumen Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Acumen PharmaceuticalsN/A -136.27% -81.64%
Xilio Therapeutics -34.06%-71.99%-20.43%

Acumen Pharmaceuticals has a beta of 0.37, indicating that its stock price is 63% less volatile than the broader market. Comparatively, Xilio Therapeutics has a beta of -0.14, indicating that its stock price is 114% less volatile than the broader market.

71.0% of Acumen Pharmaceuticals shares are owned by institutional investors. Comparatively, 54.3% of Xilio Therapeutics shares are owned by institutional investors. 10.2% of Acumen Pharmaceuticals shares are owned by insiders. Comparatively, 7.5% of Xilio Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term.

In the previous week, Acumen Pharmaceuticals had 2 more articles in the media than Xilio Therapeutics. MarketBeat recorded 3 mentions for Acumen Pharmaceuticals and 1 mentions for Xilio Therapeutics. Xilio Therapeutics' average media sentiment score of 1.87 beat Acumen Pharmaceuticals' score of 0.63 indicating that Xilio Therapeutics is being referred to more favorably in the news media.

Company Overall Sentiment
Acumen Pharmaceuticals Positive
Xilio Therapeutics Very Positive

Summary

Acumen Pharmaceuticals beats Xilio Therapeutics on 9 of the 14 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding XLO and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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XLO vs. The Competition

MetricXilio TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$58.76M$3.85B$7.15B$12.85B
Dividend YieldN/A3.65%2.57%11.17%
P/E RatioN/A14.18274.9425.36
Price / Sales1.341,374.99686.57116.78
Price / CashN/A106.5076.6551.52
Price / Book1.2215.1210.336.20
Net Income-$35.04M-$22.86M$3.50B$358.50M
7 Day Performance-0.78%-4.34%-3.32%-2.35%
1 Month Performance-0.89%0.54%-0.53%-3.23%
1 Year Performance-13.41%40.74%23.51%8.79%

Xilio Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
XLO
Xilio Therapeutics
0.2173 of 5 stars
$8.93
flat
N/A-13.4%$58.76M$43.77MN/A70
ADAG
Adagene
3.8754 of 5 stars
$3.49
-2.5%
$10.00
+186.5%
+51.8%$236.47M$9.29MN/A260
GLSI
Greenwich LifeSciences
2.7064 of 5 stars
$15.90
-0.3%
$69.00
+334.0%
+37.6%$234.11MN/AN/A3
TARA
Protara Therapeutics
1.8147 of 5 stars
$3.89
-1.3%
$26.25
+574.8%
+21.7%$232.83MN/AN/A30
IPHA
Innate Pharma
4.1065 of 5 stars
$2.05
-1.4%
$6.67
+225.2%
-6.5%$232.38M$2.79MN/A220

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This page (NASDAQ:XLO) was last updated on 9/13/2026 by MarketBeat.com Staff.
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