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Xilio Therapeutics (XLO) Competitors

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$9.01 +0.10 (+1.12%)
Closing price 10/2/2026 03:59 PM Eastern
Extended Trading
$8.98 -0.03 (-0.28%)
As of 10/2/2026 07:30 PM Eastern
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XLO vs. WHWK, CGEN, ALXO, PLX, and KROS

Should you buy Xilio Therapeutics stock or one of its competitors? Xilio Therapeutics's main competitors and comparable companies include Whitehawk Therapeutics (WHWK), Compugen (CGEN), ALX Oncology (ALXO), Protalix BioTherapeutics (PLX), and Keros Therapeutics (KROS). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Xilio Therapeutics compare to Whitehawk Therapeutics?

Xilio Therapeutics (NASDAQ:XLO) and Whitehawk Therapeutics (NASDAQ:WHWK) are both small-cap healthcare companies, but which is the better stock? We will compare the two businesses based on the strength of their dividends, institutional ownership, risk, valuation, earnings, profitability, media sentiment and analyst recommendations.

In the previous week, Xilio Therapeutics had 1 more articles in the media than Whitehawk Therapeutics. MarketBeat recorded 4 mentions for Xilio Therapeutics and 3 mentions for Whitehawk Therapeutics. Xilio Therapeutics' average media sentiment score of 0.00 equaled Whitehawk Therapeutics'average media sentiment score.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Xilio Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Whitehawk Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

54.3% of Xilio Therapeutics shares are owned by institutional investors. Comparatively, 52.1% of Whitehawk Therapeutics shares are owned by institutional investors. 7.5% of Xilio Therapeutics shares are owned by insiders. Comparatively, 49.9% of Whitehawk Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term.

Whitehawk Therapeutics has lower revenue, but higher earnings than Xilio Therapeutics. Xilio Therapeutics is trading at a lower price-to-earnings ratio than Whitehawk Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xilio Therapeutics$43.77M1.35-$35.04M-$1.64N/A
Whitehawk Therapeutics$7.14M29.54-$20.60M-$1.12N/A

Whitehawk Therapeutics has a consensus target price of $8.33, indicating a potential upside of 125.23%. Given Whitehawk Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Whitehawk Therapeutics is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00
Whitehawk Therapeutics
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.67

Xilio Therapeutics has a beta of -0.15, indicating that its share price is 115% less volatile than the broader market. Comparatively, Whitehawk Therapeutics has a beta of 0.92, indicating that its share price is 8% less volatile than the broader market.

Whitehawk Therapeutics has a net margin of 0.00% compared to Xilio Therapeutics' net margin of -34.06%. Whitehawk Therapeutics' return on equity of -53.89% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Xilio Therapeutics-34.06% -71.99% -20.43%
Whitehawk Therapeutics N/A -53.89%-49.97%

Summary

Whitehawk Therapeutics beats Xilio Therapeutics on 11 of the 15 factors compared between the two stocks.

How does Xilio Therapeutics compare to Compugen?

Xilio Therapeutics (NASDAQ:XLO) and Compugen (NASDAQ:CGEN) are both small-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their analyst recommendations, dividends, risk, media sentiment, valuation, earnings, profitability and institutional ownership.

Compugen has a consensus price target of $5.00, indicating a potential upside of 116.45%. Given Compugen's stronger consensus rating and higher probable upside, analysts plainly believe Compugen is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00
Compugen
0 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
3.00

Compugen has a net margin of 47.56% compared to Xilio Therapeutics' net margin of -34.06%. Compugen's return on equity of 42.57% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Xilio Therapeutics-34.06% -71.99% -20.43%
Compugen 47.56%42.57%26.13%

In the previous week, Xilio Therapeutics had 3 more articles in the media than Compugen. MarketBeat recorded 4 mentions for Xilio Therapeutics and 1 mentions for Compugen. Xilio Therapeutics' average media sentiment score of 0.00 equaled Compugen'saverage media sentiment score.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Xilio Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Compugen
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Xilio Therapeutics has a beta of -0.15, indicating that its share price is 115% less volatile than the broader market. Comparatively, Compugen has a beta of 2.78, indicating that its share price is 178% more volatile than the broader market.

Compugen has higher revenue and earnings than Xilio Therapeutics. Xilio Therapeutics is trading at a lower price-to-earnings ratio than Compugen, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xilio Therapeutics$43.77M1.35-$35.04M-$1.64N/A
Compugen$72.76M3.00$35.34M$0.386.08

54.3% of Xilio Therapeutics shares are held by institutional investors. Comparatively, 12.2% of Compugen shares are held by institutional investors. 7.5% of Xilio Therapeutics shares are held by insiders. Comparatively, 9.5% of Compugen shares are held by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Summary

Compugen beats Xilio Therapeutics on 14 of the 16 factors compared between the two stocks.

How does Xilio Therapeutics compare to ALX Oncology?

ALX Oncology (NASDAQ:ALXO) and Xilio Therapeutics (NASDAQ:XLO) are both small-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their valuation, analyst recommendations, earnings, media sentiment, dividends, profitability, risk and institutional ownership.

Xilio Therapeutics has higher revenue and earnings than ALX Oncology. Xilio Therapeutics is trading at a lower price-to-earnings ratio than ALX Oncology, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
ALX OncologyN/AN/A-$101.69M-$1.13N/A
Xilio Therapeutics$43.77M1.35-$35.04M-$1.64N/A

ALX Oncology presently has a consensus target price of $4.60, indicating a potential upside of 277.05%. Given ALX Oncology's stronger consensus rating and higher possible upside, research analysts clearly believe ALX Oncology is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
ALX Oncology
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.67
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

ALX Oncology has a net margin of 0.00% compared to Xilio Therapeutics' net margin of -34.06%. Xilio Therapeutics' return on equity of -71.99% beat ALX Oncology's return on equity.

Company Net Margins Return on Equity Return on Assets
ALX OncologyN/A -90.30% -67.28%
Xilio Therapeutics -34.06%-71.99%-20.43%

In the previous week, ALX Oncology had 1 more articles in the media than Xilio Therapeutics. MarketBeat recorded 5 mentions for ALX Oncology and 4 mentions for Xilio Therapeutics. ALX Oncology's average media sentiment score of 0.73 beat Xilio Therapeutics' score of 0.00 indicating that ALX Oncology is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
ALX Oncology
2 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Xilio Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

98.0% of ALX Oncology shares are owned by institutional investors. Comparatively, 54.3% of Xilio Therapeutics shares are owned by institutional investors. 12.4% of ALX Oncology shares are owned by company insiders. Comparatively, 7.5% of Xilio Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

ALX Oncology has a beta of 0.47, meaning that its share price is 53% less volatile than the broader market. Comparatively, Xilio Therapeutics has a beta of -0.15, meaning that its share price is 115% less volatile than the broader market.

Summary

ALX Oncology beats Xilio Therapeutics on 11 of the 15 factors compared between the two stocks.

How does Xilio Therapeutics compare to Protalix BioTherapeutics?

Protalix BioTherapeutics (NYSE:PLX) and Xilio Therapeutics (NASDAQ:XLO) are both small-cap healthcare companies, but which is the superior stock? We will compare the two companies based on the strength of their earnings, risk, institutional ownership, valuation, media sentiment, analyst recommendations, dividends and profitability.

Protalix BioTherapeutics has higher revenue and earnings than Xilio Therapeutics. Xilio Therapeutics is trading at a lower price-to-earnings ratio than Protalix BioTherapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Protalix BioTherapeutics$80.62M2.71$8.31M$0.2311.78
Xilio Therapeutics$43.77M1.35-$35.04M-$1.64N/A

16.5% of Protalix BioTherapeutics shares are held by institutional investors. Comparatively, 54.3% of Xilio Therapeutics shares are held by institutional investors. 6.7% of Protalix BioTherapeutics shares are held by company insiders. Comparatively, 7.5% of Xilio Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Protalix BioTherapeutics has a beta of -0.09, meaning that its stock price is 109% less volatile than the broader market. Comparatively, Xilio Therapeutics has a beta of -0.15, meaning that its stock price is 115% less volatile than the broader market.

In the previous week, Xilio Therapeutics had 4 more articles in the media than Protalix BioTherapeutics. MarketBeat recorded 4 mentions for Xilio Therapeutics and 0 mentions for Protalix BioTherapeutics. Protalix BioTherapeutics' average media sentiment score of 0.00 equaled Xilio Therapeutics'average media sentiment score.

Company Overall Sentiment
Protalix BioTherapeutics Neutral
Xilio Therapeutics Neutral

Protalix BioTherapeutics has a net margin of -21.03% compared to Xilio Therapeutics' net margin of -34.06%. Protalix BioTherapeutics' return on equity of -30.89% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Protalix BioTherapeutics-21.03% -30.89% -11.74%
Xilio Therapeutics -34.06%-71.99%-20.43%

Protalix BioTherapeutics presently has a consensus target price of $12.00, suggesting a potential upside of 342.80%. Given Protalix BioTherapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Protalix BioTherapeutics is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Protalix BioTherapeutics
0 Sell rating(s)
0 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
3.00
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

Summary

Protalix BioTherapeutics beats Xilio Therapeutics on 11 of the 15 factors compared between the two stocks.

How does Xilio Therapeutics compare to Keros Therapeutics?

Keros Therapeutics (NASDAQ:KROS) and Xilio Therapeutics (NASDAQ:XLO) are both small-cap healthcare companies, but which is the better stock? We will contrast the two businesses based on the strength of their profitability, institutional ownership, valuation, analyst recommendations, media sentiment, dividends, earnings and risk.

In the previous week, Keros Therapeutics had 3 more articles in the media than Xilio Therapeutics. MarketBeat recorded 7 mentions for Keros Therapeutics and 4 mentions for Xilio Therapeutics. Keros Therapeutics' average media sentiment score of 0.42 beat Xilio Therapeutics' score of 0.00 indicating that Keros Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Keros Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Xilio Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Xilio Therapeutics has a net margin of -34.06% compared to Keros Therapeutics' net margin of -256.60%. Keros Therapeutics' return on equity of -21.40% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Keros Therapeutics-256.60% -21.40% -19.79%
Xilio Therapeutics -34.06%-71.99%-20.43%

Keros Therapeutics currently has a consensus price target of $20.50, suggesting a potential upside of 80.46%. Given Keros Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Keros Therapeutics is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Keros Therapeutics
1 Sell rating(s)
4 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.33
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00

71.6% of Keros Therapeutics shares are owned by institutional investors. Comparatively, 54.3% of Xilio Therapeutics shares are owned by institutional investors. 12.6% of Keros Therapeutics shares are owned by insiders. Comparatively, 7.5% of Xilio Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Keros Therapeutics has higher revenue and earnings than Xilio Therapeutics. Xilio Therapeutics is trading at a lower price-to-earnings ratio than Keros Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Keros Therapeutics$244.06M0.92$87.01M-$3.70N/A
Xilio Therapeutics$43.77M1.35-$35.04M-$1.64N/A

Keros Therapeutics has a beta of 1.12, indicating that its share price is 12% more volatile than the broader market. Comparatively, Xilio Therapeutics has a beta of -0.15, indicating that its share price is 115% less volatile than the broader market.

Summary

Keros Therapeutics beats Xilio Therapeutics on 13 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding XLO and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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XLO vs. The Competition

MetricXilio TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$59.29M$3.86B$7.16B$13.28B
Dividend YieldN/A3.65%2.54%17.32%
P/E Ratio-5.4913.06275.6626.04
Price / Sales1.351,295.73609.4491.76
Price / CashN/A123.3978.8752.62
Price / Book1.2316.6310.936.31
Net Income-$35.04M-$22.71M$3.51B$362.16M
7 Day Performance-0.33%-2.99%-2.00%-1.66%
1 Month Performance-0.11%-10.60%-6.15%-4.50%
1 Year Performance-21.32%19.44%7.44%2.06%

Xilio Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
XLO
Xilio Therapeutics
0.0502 of 5 stars
$9.01
+1.1%
N/A-19.6%$59.29M$43.77MN/A76
WHWK
Whitehawk Therapeutics
2.3741 of 5 stars
$4.04
flat
$8.20
+103.0%
+90.7%$230.32M$7.14MN/A23
CGEN
Compugen
2.8637 of 5 stars
$2.49
+2.5%
$5.00
+100.8%
+31.3%$230.24M$72.76M6.5575
ALXO
ALX Oncology
3.117 of 5 stars
$1.60
-3.6%
$4.60
+187.5%
-36.1%$229.54MN/AN/A48
PLX
Protalix BioTherapeutics
2.4712 of 5 stars
$2.84
+3.3%
$12.00
+322.5%
+15.8%$228.82M$80.62MN/A226

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This page (NASDAQ:XLO) was last updated on 10/3/2026 by MarketBeat.com Staff.
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