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Xilio Therapeutics (XLO) Competitors

Xilio Therapeutics logo
$9.24 +0.14 (+1.54%)
Closing price 07/13/2026 04:00 PM Eastern
Extended Trading
$9.25 +0.01 (+0.11%)
As of 07/13/2026 04:04 PM Eastern
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XLO vs. FULC, AVXL, IVVD, CHRS, and NKTX

Should you buy Xilio Therapeutics stock or one of its competitors? MarketBeat compares Xilio Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Xilio Therapeutics include Fulcrum Therapeutics (FULC), Anavex Life Sciences (AVXL), Invivyd (IVVD), Coherus Oncology (CHRS), and Nkarta (NKTX). These companies are all part of the "pharmaceutical products" industry.

How does Xilio Therapeutics compare to Fulcrum Therapeutics?

Fulcrum Therapeutics (NASDAQ:FULC) and Xilio Therapeutics (NASDAQ:XLO) are both small-cap medical companies, but which is the superior investment? We will contrast the two companies based on the strength of their profitability, earnings, valuation, media sentiment, analyst recommendations, dividends, risk and institutional ownership.

89.8% of Fulcrum Therapeutics shares are held by institutional investors. Comparatively, 54.3% of Xilio Therapeutics shares are held by institutional investors. 7.3% of Fulcrum Therapeutics shares are held by company insiders. Comparatively, 7.5% of Xilio Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

In the previous week, Xilio Therapeutics had 1 more articles in the media than Fulcrum Therapeutics. MarketBeat recorded 3 mentions for Xilio Therapeutics and 2 mentions for Fulcrum Therapeutics. Fulcrum Therapeutics' average media sentiment score of 1.45 beat Xilio Therapeutics' score of 0.38 indicating that Fulcrum Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Fulcrum Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Xilio Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Xilio Therapeutics has lower revenue, but higher earnings than Fulcrum Therapeutics. Fulcrum Therapeutics is trading at a lower price-to-earnings ratio than Xilio Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Fulcrum Therapeutics$80M2.95-$74.88M-$1.15N/A
Xilio Therapeutics$43.77M1.39-$35.04M-$3.55N/A

Fulcrum Therapeutics presently has a consensus price target of $8.20, indicating a potential upside of 131.64%. Xilio Therapeutics has a consensus price target of $28.00, indicating a potential upside of 203.03%. Given Xilio Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Xilio Therapeutics is more favorable than Fulcrum Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Fulcrum Therapeutics
4 Sell rating(s)
7 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
1.75
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
1 Strong Buy rating(s)
2.50

Fulcrum Therapeutics has a net margin of 0.00% compared to Xilio Therapeutics' net margin of -58.52%. Fulcrum Therapeutics' return on equity of -27.80% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Fulcrum TherapeuticsN/A -27.80% -26.32%
Xilio Therapeutics -58.52%-151.42%-27.61%

Fulcrum Therapeutics has a beta of 3.01, indicating that its share price is 201% more volatile than the broader market. Comparatively, Xilio Therapeutics has a beta of -0.14, indicating that its share price is 114% less volatile than the broader market.

Summary

Fulcrum Therapeutics beats Xilio Therapeutics on 10 of the 17 factors compared between the two stocks.

How does Xilio Therapeutics compare to Anavex Life Sciences?

Xilio Therapeutics (NASDAQ:XLO) and Anavex Life Sciences (NASDAQ:AVXL) are both small-cap medical companies, but which is the superior stock? We will contrast the two businesses based on the strength of their dividends, analyst recommendations, profitability, media sentiment, earnings, risk, institutional ownership and valuation.

Anavex Life Sciences has a net margin of 0.00% compared to Xilio Therapeutics' net margin of -58.52%. Anavex Life Sciences' return on equity of -38.76% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Xilio Therapeutics-58.52% -151.42% -27.61%
Anavex Life Sciences N/A -38.76%-35.01%

In the previous week, Xilio Therapeutics had 2 more articles in the media than Anavex Life Sciences. MarketBeat recorded 3 mentions for Xilio Therapeutics and 1 mentions for Anavex Life Sciences. Anavex Life Sciences' average media sentiment score of 1.87 beat Xilio Therapeutics' score of 0.38 indicating that Anavex Life Sciences is being referred to more favorably in the news media.

Company Overall Sentiment
Xilio Therapeutics Neutral
Anavex Life Sciences Very Positive

54.3% of Xilio Therapeutics shares are held by institutional investors. Comparatively, 31.6% of Anavex Life Sciences shares are held by institutional investors. 7.5% of Xilio Therapeutics shares are held by insiders. Comparatively, 11.0% of Anavex Life Sciences shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Xilio Therapeutics has higher revenue and earnings than Anavex Life Sciences. Anavex Life Sciences is trading at a lower price-to-earnings ratio than Xilio Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xilio Therapeutics$43.77M1.39-$35.04M-$3.55N/A
Anavex Life SciencesN/AN/A-$46.38M-$0.46N/A

Xilio Therapeutics has a beta of -0.14, indicating that its share price is 114% less volatile than the broader market. Comparatively, Anavex Life Sciences has a beta of 1.14, indicating that its share price is 14% more volatile than the broader market.

Xilio Therapeutics currently has a consensus price target of $28.00, indicating a potential upside of 203.03%. Anavex Life Sciences has a consensus price target of $21.33, indicating a potential upside of 807.80%. Given Anavex Life Sciences' higher possible upside, analysts plainly believe Anavex Life Sciences is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
1 Strong Buy rating(s)
2.50
Anavex Life Sciences
1 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
0 Strong Buy rating(s)
2.40

Summary

Xilio Therapeutics and Anavex Life Sciences tied by winning 8 of the 16 factors compared between the two stocks.

How does Xilio Therapeutics compare to Invivyd?

Xilio Therapeutics (NASDAQ:XLO) and Invivyd (NASDAQ:IVVD) are both small-cap medical companies, but which is the superior business? We will contrast the two companies based on the strength of their dividends, institutional ownership, valuation, profitability, analyst recommendations, earnings, media sentiment and risk.

Xilio Therapeutics presently has a consensus target price of $28.00, suggesting a potential upside of 203.03%. Invivyd has a consensus target price of $8.00, suggesting a potential upside of 915.87%. Given Invivyd's higher probable upside, analysts clearly believe Invivyd is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
1 Strong Buy rating(s)
2.50
Invivyd
1 Sell rating(s)
2 Hold rating(s)
3 Buy rating(s)
0 Strong Buy rating(s)
2.33

Xilio Therapeutics has higher earnings, but lower revenue than Invivyd. Xilio Therapeutics is trading at a lower price-to-earnings ratio than Invivyd, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xilio Therapeutics$43.77M1.39-$35.04M-$3.55N/A
Invivyd$53.43M4.34-$52.49M-$0.31N/A

Xilio Therapeutics has a beta of -0.14, meaning that its share price is 114% less volatile than the broader market. Comparatively, Invivyd has a beta of 0.67, meaning that its share price is 33% less volatile than the broader market.

Xilio Therapeutics has a net margin of -58.52% compared to Invivyd's net margin of -138.90%. Invivyd's return on equity of -53.48% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Xilio Therapeutics-58.52% -151.42% -27.61%
Invivyd -138.90%-53.48%-41.56%

In the previous week, Invivyd had 1 more articles in the media than Xilio Therapeutics. MarketBeat recorded 4 mentions for Invivyd and 3 mentions for Xilio Therapeutics. Invivyd's average media sentiment score of 0.46 beat Xilio Therapeutics' score of 0.38 indicating that Invivyd is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Xilio Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Invivyd
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

54.3% of Xilio Therapeutics shares are held by institutional investors. Comparatively, 70.4% of Invivyd shares are held by institutional investors. 7.5% of Xilio Therapeutics shares are held by insiders. Comparatively, 12.3% of Invivyd shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Summary

Invivyd beats Xilio Therapeutics on 12 of the 17 factors compared between the two stocks.

How does Xilio Therapeutics compare to Coherus Oncology?

Coherus Oncology (NASDAQ:CHRS) and Xilio Therapeutics (NASDAQ:XLO) are both small-cap medical companies, but which is the better investment? We will contrast the two companies based on the strength of their analyst recommendations, valuation, media sentiment, profitability, risk, dividends, earnings and institutional ownership.

72.8% of Coherus Oncology shares are owned by institutional investors. Comparatively, 54.3% of Xilio Therapeutics shares are owned by institutional investors. 8.1% of Coherus Oncology shares are owned by company insiders. Comparatively, 7.5% of Xilio Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Coherus Oncology has a beta of 0.97, suggesting that its stock price is 3% less volatile than the broader market. Comparatively, Xilio Therapeutics has a beta of -0.14, suggesting that its stock price is 114% less volatile than the broader market.

Coherus Oncology presently has a consensus price target of $8.67, indicating a potential upside of 489.57%. Xilio Therapeutics has a consensus price target of $28.00, indicating a potential upside of 203.03%. Given Coherus Oncology's stronger consensus rating and higher probable upside, equities research analysts plainly believe Coherus Oncology is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Coherus Oncology
0 Sell rating(s)
1 Hold rating(s)
3 Buy rating(s)
0 Strong Buy rating(s)
2.75
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
1 Strong Buy rating(s)
2.50

In the previous week, Xilio Therapeutics had 1 more articles in the media than Coherus Oncology. MarketBeat recorded 3 mentions for Xilio Therapeutics and 2 mentions for Coherus Oncology. Coherus Oncology's average media sentiment score of 1.28 beat Xilio Therapeutics' score of 0.38 indicating that Coherus Oncology is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Coherus Oncology
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Xilio Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Coherus Oncology has higher earnings, but lower revenue than Xilio Therapeutics. Xilio Therapeutics is trading at a lower price-to-earnings ratio than Coherus Oncology, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Coherus Oncology$42.17M5.38$168.02M$1.670.88
Xilio Therapeutics$43.77M1.39-$35.04M-$3.55N/A

Coherus Oncology has a net margin of 397.30% compared to Xilio Therapeutics' net margin of -58.52%. Xilio Therapeutics' return on equity of -151.42% beat Coherus Oncology's return on equity.

Company Net Margins Return on Equity Return on Assets
Coherus Oncology397.30% -198.90% -46.65%
Xilio Therapeutics -58.52%-151.42%-27.61%

Summary

Coherus Oncology beats Xilio Therapeutics on 12 of the 17 factors compared between the two stocks.

How does Xilio Therapeutics compare to Nkarta?

Xilio Therapeutics (NASDAQ:XLO) and Nkarta (NASDAQ:NKTX) are both small-cap medical companies, but which is the better stock? We will contrast the two companies based on the strength of their institutional ownership, risk, dividends, valuation, analyst recommendations, media sentiment, profitability and earnings.

In the previous week, Xilio Therapeutics had 2 more articles in the media than Nkarta. MarketBeat recorded 3 mentions for Xilio Therapeutics and 1 mentions for Nkarta. Nkarta's average media sentiment score of 1.87 beat Xilio Therapeutics' score of 0.38 indicating that Nkarta is being referred to more favorably in the news media.

Company Overall Sentiment
Xilio Therapeutics Neutral
Nkarta Very Positive

54.3% of Xilio Therapeutics shares are held by institutional investors. Comparatively, 80.5% of Nkarta shares are held by institutional investors. 7.5% of Xilio Therapeutics shares are held by insiders. Comparatively, 9.8% of Nkarta shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Nkarta has a net margin of 0.00% compared to Xilio Therapeutics' net margin of -58.52%. Nkarta's return on equity of -30.90% beat Xilio Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Xilio Therapeutics-58.52% -151.42% -27.61%
Nkarta N/A -30.90%-24.20%

Xilio Therapeutics has higher revenue and earnings than Nkarta. Xilio Therapeutics is trading at a lower price-to-earnings ratio than Nkarta, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xilio Therapeutics$43.77M1.39-$35.04M-$3.55N/A
NkartaN/AN/A-$104.08M-$1.34N/A

Xilio Therapeutics presently has a consensus target price of $28.00, indicating a potential upside of 203.03%. Nkarta has a consensus target price of $10.75, indicating a potential upside of 285.30%. Given Nkarta's stronger consensus rating and higher possible upside, analysts clearly believe Nkarta is more favorable than Xilio Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xilio Therapeutics
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
1 Strong Buy rating(s)
2.50
Nkarta
1 Sell rating(s)
0 Hold rating(s)
4 Buy rating(s)
1 Strong Buy rating(s)
2.83

Xilio Therapeutics has a beta of -0.14, indicating that its stock price is 114% less volatile than the broader market. Comparatively, Nkarta has a beta of 0.9, indicating that its stock price is 10% less volatile than the broader market.

Summary

Nkarta beats Xilio Therapeutics on 12 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding XLO and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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XLO vs. The Competition

MetricXilio TherapeuticsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$59.83M$3.71B$7.05B$12.61B
Dividend YieldN/A2.20%2.68%8.00%
P/E Ratio-2.6020.8527.1124.26
Price / Sales1.39314.01589.96117.88
Price / CashN/A61.9829.2249.36
Price / Book1.268.4910.746.29
Net Income-$35.04M$23.83M$3.58B$330.66M
7 Day Performance-0.75%-3.56%-2.11%-1.35%
1 Month Performance11.19%6.31%3.27%-0.64%
1 Year Performance-10.76%48.30%26.31%19.08%

Xilio Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
XLO
Xilio Therapeutics
2.092 of 5 stars
$9.24
+1.5%
$28.00
+203.0%
-10.1%$59.83M$43.77MN/A70
FULC
Fulcrum Therapeutics
3.5877 of 5 stars
$3.77
+1.3%
$8.20
+117.5%
-54.8%$247.88M$80MN/A100
AVXL
Anavex Life Sciences
2.8313 of 5 stars
$2.71
+1.9%
$21.33
+687.2%
-78.8%$246.51MN/AN/A40
IVVD
Invivyd
3.5569 of 5 stars
$0.94
+12.9%
$8.00
+749.4%
+6.6%$245.70M$53.43MN/A100
CHRS
Coherus Oncology
2.8055 of 5 stars
$1.67
+7.1%
$8.67
+419.0%
+67.0%$240.63M$42.17M1.00330

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This page (NASDAQ:XLO) was last updated on 7/14/2026 by MarketBeat.com Staff.
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