Dafna Capital Management LLC Top Holdings and 13F Report (2025)

About Dafna Capital Management LLC

Investment Activity

Dafna Capital Management LLC has $352.66 million in total holdings as of March 31, 2025.
Dafna Capital Management LLC owns shares of 83 different stocks, but just 27 companies or ETFs make up 80% of its holdings.
Approximately 7.58% of the portfolio was purchased this quarter.
About 4.78% of the portfolio was sold this quarter.
This quarter, Dafna Capital Management LLC has purchased 82 new stocks and bought additional shares in 24 stocks.
Dafna Capital Management LLC sold shares of 15 stocks and completely divested from 7 stocks this quarter.

Largest Holdings

SPDR S&P Biotech ETF: $32,805,356
Stereotaxis: $24,077,775
Revolution Medicines: $23,202,383
Merus: $19,437,330
AtriCure: $19,106,727

Largest New Holdings this Quarter

24823R105 - Denali Therapeutics: $1,738,801 Holding
68622P109 - ORIC Pharmaceuticals: $1,350,360 Holding
92941V308 - VYNE Therapeutics: $1,005,043 Holding
500946108 - KORRO BIO INC: $819,767 Holding
14147L108 - Cardiff Oncology: $471,000 Holding

Largest Purchases this Quarter

Arcus Biosciences: 370,909 shares (about $2.91M)
Mineralys Therapeutics: 162,700 shares (about $2.58M)
Stoke Therapeutics: 272,901 shares (about $1.81M)
Inogen: 249,275 shares (about $1.78M)
Denali Therapeutics: 127,900 shares (about $1.74M)

Largest Sales this Quarter

Ascendis Pharma A/S: 22,957 shares (about $3.58M)
AxoGen: 166,100 shares (about $3.07M)
AtriCure: 49,400 shares (about $1.59M)
Alkermes: 26,500 shares (about $875.03K)
BioCryst Pharmaceuticals: 108,745 shares (about $815.59K)

Sector Allocation Over Time

Selling

Neutral

Buying

Latest 13F Holdings and Changes Since Previous Quarterly Filing

Issuer Name	Holdings Value	Approximate Purchase/Sale	Change in Shares	Shares Held	% of Portfolio	Sector
XBI SPDR S&P Biotech ETF	$32,805,356	$567,700 ▲	1.8%	404,505	9.3%	ETF
STXS Stereotaxis	$24,077,775		0.0%	13,680,554	6.8%	Medical
RVMD Revolution Medicines	$23,202,383	$884,000 ▲	4.0%	656,176	6.6%	Medical
MRUS Merus	$19,437,330	$420,900 ▲	2.2%	461,804	5.5%	Medical
ATRC AtriCure	$19,106,727	$1,593,644 ▼	-7.7%	592,273	5.4%	Medical
CYTK Cytokinetics	$15,999,639		0.0%	398,100	4.5%	Medical
BPMC Blueprint Medicines	$13,476,798	$221,275 ▲	1.7%	152,263	3.8%	Medical
IBB iShares Biotechnology ETF	$13,109,750		0.0%	102,500	3.7%	Finance
AXGN AxoGen	$12,594,467	$3,072,850 ▼	-19.6%	680,782	3.6%	Medical
ASND Ascendis Pharma A/S	$12,530,832	$3,578,078 ▼	-22.2%	80,398	3.6%	Medical
IDYA IDEAYA Biosciences	$9,653,225	$1,482,439 ▲	18.1%	589,330	2.7%	Medical
XENE Xenon Pharmaceuticals	$9,183,943		0.0%	273,739	2.6%	Medical
KALV KalVista Pharmaceuticals	$8,682,223	$684,541 ▼	-7.3%	752,359	2.5%	Medical
NBIX Neurocrine Biosciences	$7,920,619		0.0%	71,615	2.2%	Medical
SNDX Syndax Pharmaceuticals	$6,689,207	$30,712 ▲	0.5%	544,502	1.9%	Medical
DAWN Day One Biopharmaceuticals	$5,799,709		0.0%	731,363	1.6%	Medical
TNDM Tandem Diabetes Care	$5,637,025	$1,360,360 ▲	31.8%	294,208	1.6%	Medical
URGN UroGen Pharma	$5,447,216		0.0%	492,515	1.5%	Medical
BHVN Biohaven	$5,294,449		0.0%	220,235	1.5%	Medical
MLYS Mineralys Therapeutics	$4,910,096	$2,583,676 ▲	111.1%	309,200	1.4%	Medical
RCUS Arcus Biosciences	$4,907,239	$2,911,636 ▲	145.9%	625,126	1.4%	Medical
ASCENDIS PHARMA A/S	$4,710,000		0.0%	4,000,000	1.3%	NOTE 2.250% 4/0
DXCM DexCom	$4,476,546		0.0%	65,552	1.3%	Medical
BCRX BioCryst Pharmaceuticals	$4,186,913	$815,588 ▼	-16.3%	558,255	1.2%	Medical
EWTX Edgewise Therapeutics	$4,029,080	$88,000 ▼	-2.1%	183,140	1.1%	Medical
GLPG Galapagos	$3,269,996		0.0%	130,175	0.9%	Medical
INGN Inogen	$3,266,003	$1,777,331 ▲	119.4%	458,065	0.9%	Medical
PODD Insulet	$3,125,059	$131,305 ▼	-4.0%	11,900	0.9%	Medical
ALKS Alkermes	$3,110,484	$875,030 ▼	-22.0%	94,200	0.9%	Medical
KURA Kura Oncology	$3,058,229	$99,000 ▲	3.3%	463,368	0.9%	Medical
STOK Stoke Therapeutics	$2,952,587	$1,814,792 ▲	159.5%	443,998	0.8%	Medical
IMVT Immunovant	$2,905,232	$1,059,580 ▲	57.4%	169,996	0.8%	Medical
BICARA THERAPEUTICS INC	$2,762,373	$1,387,708 ▲	100.9%	212,001	0.8%	COM
ARAY Accuray	$2,188,021		0.0%	1,222,358	0.6%	Medical
TSVT 2seventy bio	$2,120,505		0.0%	429,252	0.6%	Medical
PRQR ProQR Therapeutics	$2,084,856		0.0%	1,567,561	0.6%	Medical
CMPS COMPASS Pathways	$2,033,592	$1,338,011 ▲	192.4%	711,046	0.6%	Medical
ALLO Allogene Therapeutics	$2,014,972	$204,400 ▲	11.3%	1,380,118	0.6%	Medical
TELA TELA Bio	$1,758,055		0.0%	1,441,029	0.5%	Medical
ALGN Align Technology	$1,747,460	$873,730 ▲	100.0%	11,000	0.5%	Medical
DNLI Denali Therapeutics	$1,738,801	$1,738,801 ▲	New Holding	127,900	0.5%	Medical
ATXS Astria Therapeutics	$1,680,899	$80,100 ▲	5.0%	314,775	0.5%	Medical
VKTX Viking Therapeutics	$1,558,061		0.0%	64,516	0.4%	Medical
RGLS Regulus Therapeutics	$1,482,558	$49,042 ▼	-3.2%	847,176	0.4%	Medical
BWAY BrainsWay	$1,482,368	$347,312 ▼	-19.0%	156,533	0.4%	Medical
ORIC ORIC Pharmaceuticals	$1,350,360	$1,350,360 ▲	New Holding	242,000	0.4%	Medical
KROS Keros Therapeutics	$1,327,920		0.0%	130,316	0.4%	Medical
LEXEO THERAPEUTICS INC	$1,311,948	$52,050 ▼	-3.8%	378,083	0.4%	COM
ITOS iTeos Therapeutics	$1,273,682	$149,250 ▲	13.3%	213,347	0.4%	Medical
PALVELLA THERAPEUTICS INC	$1,213,311	$786,631 ▼	-39.3%	43,348	0.3%	COM
SPRY ARS Pharmaceuticals	$1,198,748	$81,770 ▲	7.3%	95,290	0.3%	Medical
LCTX Lineage Cell Therapeutics	$1,134,136		0.0%	2,511,374	0.3%	Medical
ALEC Alector	$1,122,901		0.0%	912,928	0.3%	Medical
FHTX Foghorn Therapeutics	$1,112,345	$430,828 ▲	63.2%	304,752	0.3%	Medical
IMTX Immatics	$1,104,950		0.0%	245,000	0.3%	Medical
GPCR Structure Therapeutics	$1,021,290	$406,785 ▲	66.2%	59,000	0.3%	Medical
VYNE VYNE Therapeutics	$1,005,043	$1,005,043 ▲	New Holding	636,103	0.3%	Medical
MDWD MediWound	$1,000,714		0.0%	64,479	0.3%	Medical
GOSS Gossamer Bio	$998,639	$551,549 ▼	-35.6%	907,854	0.3%	Medical
BNTX BioNTech	$956,130	$182,120 ▲	23.5%	10,500	0.3%	Medical
AUTL Autolus Therapeutics	$909,334		0.0%	586,667	0.3%	Medical
SAGE Sage Therapeutics	$860,190		0.0%	108,200	0.2%	Medical
KORRO BIO INC	$819,767	$819,767 ▲	New Holding	47,086	0.2%	COM
IPSC Century Therapeutics	$811,215		0.0%	1,704,232	0.2%	Medical
LRMR Larimar Therapeutics	$798,583		0.0%	371,434	0.2%	Medical
POLYPID LTD	$789,350		0.0%	291,273	0.2%	COM
TSHA Taysha Gene Therapies	$726,275		0.0%	522,500	0.2%	Medical
BCYC Bicycle Therapeutics	$685,984	$339,600 ▼	-33.1%	80,799	0.2%	Medical
NEUROGENE INC	$603,065		0.0%	51,500	0.2%	COM
CRDF Cardiff Oncology	$471,000	$471,000 ▲	New Holding	150,000	0.1%	Medical
ERAS Erasca	$465,800	$465,800 ▲	New Holding	340,000	0.1%	Medical
IFRX InflaRx	$459,000	$459,000 ▲	New Holding	450,000	0.1%	Medical
ACET Adicet Bio	$453,000		0.0%	600,000	0.1%	Medical
AQST Aquestive Therapeutics	$411,800	$43,500 ▲	11.8%	142,000	0.1%	Medical
CGEN Compugen	$397,707	$255,208 ▼	-39.1%	272,402	0.1%	Medical
ADCT ADC Therapeutics	$315,954		0.0%	224,081	0.1%	Medical
STRO Sutro Biopharma	$284,364		0.0%	437,079	0.1%	Medical
APRE Aprea Therapeutics	$279,835		0.0%	137,174	0.1%	Medical
BIOMX INC	$222,911		0.0%	401,136	0.1%	COM NEW
NVRO Nevro	$221,920		0.0%	38,000	0.1%	Medical
BDTX Black Diamond Therapeutics	$217,000		0.0%	140,000	0.1%	Medical
SPRO Spero Therapeutics	$90,000		0.0%	125,000	0.0%	Medical
TNYA Tenaya Therapeutics	$26,977	$26,977 ▲	New Holding	47,319	0.0%	Medical
CNTA Centessa Pharmaceuticals	$0	$794,838 ▼	-100.0%	0	0.0%	Medical
VIR Vir Biotechnology	$0	$734,000 ▼	-100.0%	0	0.0%	Medical
ACRV Acrivon Therapeutics	$0	$676,732 ▼	-100.0%	0	0.0%	Medical
MASI Masimo	$0	$495,900 ▼	-100.0%	0	0.0%	Medical
PERSPECTIVE THERAPEUTICS INC	$0	$415,239 ▼	-100.0%	0	0.0%	COM NEW
SLRN Acelyrin	$0	$276,285 ▼	-100.0%	0	0.0%	Medical
CMPX Compass Therapeutics	$0	$229,671 ▼	-100.0%	0	0.0%	Medical

Showing largest 100 holdings. View all holdings.

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Dafna Capital Management LLC Top Holdings and 13F Report (2025)

About Dafna Capital Management LLC

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

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Dafna Capital Management LLC Top Holdings and 13F Report (2025)

About Dafna Capital Management LLC

Investment Activity

Largest Holdings

Largest New Holdings this Quarter

Largest Purchases this Quarter

Largest Sales this Quarter

Sector Allocation Over Time

Map of 500 Largest Holdings ofDafna Capital Management LLC

Latest 13F Holdings and Changes Since Previous Quarterly Filing

More Institutional Buying and Selling Information

MarketBeat All Access Features

Best-in-Class Portfolio Monitoring

Stock Ideas and Recommendations

Advanced Stock Screeners and Research Tools