Dafna Capital Management LLC Top Holdings and 13F Report (2025) About Dafna Capital Management LLCInvestment ActivityDafna Capital Management LLC has $362.25 million in total holdings as of March 31, 2025.Dafna Capital Management LLC owns shares of 76 different stocks, but just 25 companies or ETFs make up 80% of its holdings.Approximately 4.21% of the portfolio was purchased this quarter.About 6.80% of the portfolio was sold this quarter.This quarter, Dafna Capital Management LLC has purchased 83 new stocks and bought additional shares in 22 stocks.Dafna Capital Management LLC sold shares of 21 stocks and completely divested from 10 stocks this quarter.Largest Holdings SPDR S&P Biotech ETF $34,457,830Stereotaxis $29,002,774Revolution Medicines $24,913,305Blueprint Medicines $21,632,041Merus $20,977,090 Largest New Holdings this Quarter 20454B104 - Compass Therapeutics $1,369,316 Holding640268306 - NEKTAR THERAPEUTICS $258,400 Holding74276L105 - PROCEPT BioRobotics $172,800 Holding Largest Purchases this Quarter Blueprint Medicines 16,500 shares (about $2.11M)Compass Therapeutics 526,660 shares (about $1.37M)Inogen 147,560 shares (about $1.04M)BICARA THERAPEUTICS INC 105,000 shares (about $975.45K)Day One Biopharmaceuticals 147,800 shares (about $960.70K) Largest Sales this Quarter Merus 63,000 shares (about $3.31M)BioCryst Pharmaceuticals 340,000 shares (about $3.05M)Urogen Pharma 143,000 shares (about $1.96M)KalVista Pharmaceuticals 170,602 shares (about $1.93M)Ascendis Pharma A/S 7,721 shares (about $1.33M) Sector Allocation Over TimeMap of 500 Largest Holdings ofDafna Capital Management LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorXBISPDR S&P Biotech ETF$34,457,830$912,230 ▲2.7%415,5059.5%ETFSTXSStereotaxis$29,002,7740.0%13,680,5548.0%MedicalRVMDRevolution Medicines$24,913,305$772,590 ▲3.2%677,1766.9%MedicalBPMCBlueprint Medicines$21,632,041$2,114,970 ▲10.8%168,7636.0%MedicalMRUSMerus$20,977,090$3,313,800 ▼-13.6%398,8045.8%MedicalATRCAtriCure$19,408,7860.0%592,2735.4%MedicalCYTKCytokinetics$13,153,2240.0%398,1003.6%MedicalIDYAIDEAYA Biosciences$13,013,272$625,555 ▲5.0%619,0903.6%MedicalIBBiShares Biotechnology ETF$12,967,2750.0%102,5003.6%FinanceASNDAscendis Pharma A/S$12,544,050$1,332,645 ▼-9.6%72,6773.5%MedicalXENEXenon Pharmaceuticals$9,012,491$444,460 ▲5.2%287,9392.5%MedicalNBIXNeurocrine Biosciences$8,875,599$125,690 ▼-1.4%70,6152.5%MedicalAXGNAxoGen$8,048,335$661,850 ▲9.0%741,7822.2%MedicalKALVKalVista Pharmaceuticals$6,576,763$1,928,656 ▼-22.7%581,7571.8%MedicalDXCMDexCom$5,722,0340.0%65,5521.6%MedicalDAWNDay One Biopharmaceuticals$5,714,560$960,700 ▲20.2%879,1631.6%MedicalSTOKStoke Therapeutics$5,697,382$658,005 ▲13.1%501,9721.6%MedicalTNDMTandem Diabetes Care$5,484,0370.0%294,2081.5%MedicalRCUSArcus Biosciences$5,108,876$20,350 ▲0.4%627,6261.4%MedicalSNDXSyndax Pharmaceuticals$5,090,833$8,429 ▼-0.2%543,6021.4%MedicalMLYSMineralys Therapeutics$5,026,706$843,230 ▲20.2%371,5231.4%MedicalASCENDIS PHARMA A/S$5,010,0000.0%4,000,0001.4%NOTE 2.250% 4/0URGNUrogen Pharma$4,788,356$1,959,100 ▼-29.0%349,5151.3%MedicalINGNInogen$4,257,544$1,037,347 ▲32.2%605,6251.2%MedicalGLPGGalapagos$3,643,5980.0%130,1751.0%MedicalBHVNBiohaven$3,319,166$211,650 ▲6.8%235,2350.9%MedicalPRQRProQR Therapeutics$3,197,8240.0%1,567,5610.9%MedicalEWTXEdgewise Therapeutics$3,122,015$721,050 ▲30.0%238,1400.9%MedicalPODDInsulet$3,110,382$628,360 ▼-16.8%9,9000.9%MedicalIMVTImmunovant$3,063,888$343,952 ▲12.6%191,4930.8%MedicalALKSAlkermes$2,968,230$273,168 ▲10.1%103,7480.8%MedicalBICARA THERAPEUTICS INC$2,944,939$975,450 ▲49.5%317,0010.8%COMTELATELA Bio$2,795,5960.0%1,441,0290.8%MedicalKURAKura Oncology$2,673,6330.0%463,3680.7%MedicalDNLIDenali Therapeutics$2,357,315$567,994 ▲31.7%168,5000.7%MedicalCMPSCOMPASS Pathways$2,270,929$280,000 ▲14.1%811,0460.6%MedicalALGNAlign Technology$2,082,6300.0%11,0000.6%MedicalBCRXBioCryst Pharmaceuticals$1,955,565$3,046,400 ▼-60.9%218,2550.5%MedicalATXSAstria Therapeutics$1,740,794$53,600 ▲3.2%324,7750.5%MedicalKROSKeros Therapeutics$1,739,7190.0%130,3160.5%MedicalVKTXViking Therapeutics$1,709,6740.0%64,5160.5%MedicalARAYAccuray$1,674,6300.0%1,222,3580.5%MedicalBWAYBrainsway$1,672,036$386,373 ▼-18.8%127,1510.5%MedicalALLOAllogene Therapeutics$1,559,5330.0%1,380,1180.4%MedicalLEXEO THERAPEUTICS INC$1,519,8940.0%378,0830.4%COMFHTXFoghorn Therapeutics$1,412,124$20,210 ▼-1.4%300,4520.4%MedicalITOSiTeos Therapeutics$1,404,245$722,825 ▼-34.0%140,8470.4%MedicalORICOric Pharmaceuticals$1,373,001$1,083,300 ▼-44.1%135,2710.4%MedicalCMPXCompass Therapeutics$1,369,316$1,369,316 ▲New Holding526,6600.4%MedicalIMTXImmatics$1,318,1000.0%245,0000.4%MedicalALECAlector$1,278,0990.0%912,9280.4%MedicalMDWDMediWound$1,248,9580.0%64,4790.3%MedicalGPCRStructure Therapeutics$1,223,6600.0%59,0000.3%MedicalBDTXBlack Diamond Therapeutics$1,168,080$820,880 ▲236.4%471,0000.3%MedicalLRMRLarimar Therapeutics$1,073,4440.0%371,4340.3%MedicalVYNEVYNE Therapeutics$1,049,5700.0%636,1030.3%MedicalGOSSGossamer Bio$1,045,403$71,258 ▼-6.4%849,9210.3%MedicalPALVELLA THERAPEUTICS INC$977,0640.0%43,3480.3%COMAUTLAutolus Therapeutics$970,404$367,196 ▼-27.5%425,6160.3%MedicalIPSCCentury Therapeutics$952,1540.0%1,704,2320.3%MedicalNEUROGENE INC$763,885$6,040 ▼-0.8%51,0960.2%COMBNTXBioNTech$745,290$372,645 ▼-33.3%7,0000.2%MedicalPOLYPID LTD$733,887$294,307 ▼-28.6%207,9000.2%COMKORRO BIO INC$720,561$132,457 ▲22.5%57,6910.2%COMCGENCompugen$484,8760.0%272,4020.1%MedicalAQSTAquestive Therapeutics$470,0200.0%142,0000.1%MedicalBCYCBicycle Therapeutics$448,219$113,334 ▼-20.2%64,4920.1%MedicalERASErasca$444,500$12,700 ▲2.9%350,0000.1%MedicalACETAdicet Bio$329,400$36,600 ▼-10.0%540,0000.1%MedicalADCTADC Therapeutics$327,177$273,360 ▼-45.5%122,0810.1%MedicalSTROSutro Biopharma$312,0310.0%437,0790.1%MedicalNEKTAR THERAPEUTICS$258,400$258,400 ▲New Holding10,0000.1%COM NEWAPREAprea Therapeutics$231,8240.0%137,1740.1%MedicalBIOMX INC$180,5110.0%401,1360.0%COM NEWPRCTPROCEPT BioRobotics$172,800$172,800 ▲New Holding3,0000.0%MedicalIFRXInflaRx$158,000$197,500 ▼-55.6%200,0000.0%MedicalTSVT2seventy bio$0$2,120,505 ▼-100.0%00.0%MedicalRGLSRegulus Therapeutics$0$1,482,558 ▼-100.0%00.0%MedicalSPRYARS Pharmaceuticals$0$1,198,748 ▼-100.0%00.0%MedicalLCTXLineage Cell Therapeutics$0$1,134,136 ▼-100.0%00.0%MedicalSAGESage Therapeutics$0$860,190 ▼-100.0%00.0%MedicalTSHATaysha Gene Therapies$0$726,275 ▼-100.0%00.0%MedicalCRDFCardiff Oncology$0$471,000 ▼-100.0%00.0%MedicalNVRONevro$0$221,920 ▼-100.0%00.0%MedicalSPROSpero Therapeutics$0$90,000 ▼-100.0%00.0%MedicalTNYATenaya Therapeutics$0$26,977 ▼-100.0%00.0%MedicalShowing largest 100 holdings. 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