Sphera Funds Management Ltd. Top Holdings and 13F Report (2025) About Sphera Funds Management Ltd.Investment ActivitySphera Funds Management Ltd. has $426.14 million in total holdings as of June 30, 2025.Sphera Funds Management Ltd. owns shares of 104 different stocks, but just 47 companies or ETFs make up 80% of its holdings.Approximately 24.62% of the portfolio was purchased this quarter.About 30.48% of the portfolio was sold this quarter.This quarter, Sphera Funds Management Ltd. has purchased 113 new stocks and bought additional shares in 24 stocks.Sphera Funds Management Ltd. sold shares of 53 stocks and completely divested from 27 stocks this quarter.Largest Holdings Teva Pharmaceutical Industries $27,167,792Nova $20,870,067SPDR S&P Biotech ETF $16,586,000Syndax Pharmaceuticals $14,717,697Tower Semiconductor $11,475,699 Largest New Holdings this Quarter 78464A870 - SPDR S&P Biotech ETF $16,586,000 Holding34962G208 - FORTE BIOSCIENCES INC $6,401,759 Holding61559X104 - MoonLake Immunotherapeutics $5,900,000 Holding03152W109 - Amicus Therapeutics $5,676,814 Holding89532M101 - Trevi Therapeutics $4,375,765 Holding Largest Purchases this Quarter SPDR S&P Biotech ETF 200,000 shares (about $16.59M)Tower Semiconductor 203,173 shares (about $8.81M)Biogen 60,000 shares (about $7.54M)FORTE BIOSCIENCES INC 495,109 shares (about $6.40M)Cytokinetics 181,757 shares (about $6.01M) Largest Sales this Quarter iShares 20+ Year Treasury Bond ETF 208,100 shares (about $18.36M)BridgeBio Pharma 229,600 shares (about $9.91M)Sanofi 85,000 shares (about $4.11M)Nova 14,861 shares (about $4.09M)89BIO 412,668 shares (about $4.05M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSphera Funds Management Ltd. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorTEVATeva Pharmaceutical Industries$27,167,792$818,039 ▲3.1%1,620,9906.4%MedicalNVMINova$20,870,067$4,089,747 ▼-16.4%75,8364.9%Computer and TechnologyXBISPDR S&P Biotech ETF$16,586,000$16,586,000 ▲New Holding200,0003.9%ETFSNDXSyndax Pharmaceuticals$14,717,697$865,420 ▼-5.6%1,571,5643.5%MedicalTSEMTower Semiconductor$11,475,699$8,807,550 ▲330.1%264,7222.7%Computer and TechnologyCYTKCytokinetics$10,794,763$6,005,251 ▲125.4%326,7182.5%MedicalSNYSanofi$10,604,770$4,106,350 ▼-27.9%219,5152.5%MedicalBIIBBiogen$10,391,065$7,535,400 ▲263.9%82,7382.4%MedicalRAREUltragenyx Pharmaceutical$10,205,707$1,334,412 ▼-11.6%280,6852.4%MedicalAZNAstraZeneca$9,437,993$2,795,200 ▼-22.8%135,0602.2%MedicalLLYEli Lilly and Company$8,995,776$116,929 ▼-1.3%11,5402.1%MedicalPRAXIS PRECISION MEDICINES I$8,820,282$1,299,471 ▼-12.8%209,7572.1%COM NEWNVDANVIDIA$8,612,825$3,935,531 ▲84.1%54,5152.0%Computer and TechnologyCLDXCelldex Therapeutics$8,537,639$1,796,681 ▼-17.4%419,5402.0%MedicalNVONovo Nordisk A/S$7,293,827$856,055 ▼-10.5%105,6771.7%MedicalAMZNAmazon.com$7,117,231$913,979 ▼-11.4%32,4411.7%Retail/WholesaleCIDARA THERAPEUTICS INC$6,722,029$5,887,724 ▲705.7%138,0011.6%COM NEWORAOrmat Technologies$6,533,280$502,560 ▼-7.1%78,0001.5%EnergyMLYSMineralys Therapeutics$6,507,578$209,011 ▲3.3%480,9741.5%MedicalFORTE BIOSCIENCES INC$6,401,759$6,401,759 ▲New Holding495,1091.5%COM NEWMETAMeta Platforms$6,292,955$1,059,897 ▼-14.4%8,5261.5%Computer and TechnologyJNJJohnson & Johnson$6,236,935$1,833,000 ▼-22.7%40,8311.5%MedicalBBIOBridgeBio Pharma$5,916,005$9,914,127 ▼-62.6%137,0081.4%MedicalMLTXMoonLake Immunotherapeutics$5,900,000$5,900,000 ▲New Holding125,0001.4%MedicalMSFTMicrosoft$5,865,459$3,581,352 ▲156.8%11,7921.4%Computer and TechnologyFOLDAmicus Therapeutics$5,676,814$5,676,814 ▲New Holding990,7181.3%MedicalORMAT TECHNOLOGIES INC$5,609,9000.0%5,037,0001.3%DEBT 2.500% 7/1PHVSPharvaris$5,454,786$1,301,080 ▼-19.3%309,9311.3%MedicalELDNEledon Pharmaceuticals$5,395,095$857,197 ▼-13.7%1,990,8101.3%MedicalSRPTSarepta Therapeutics$5,289,423$2,588,803 ▲95.9%309,3231.2%MedicalTVTXTravere Therapeutics$4,962,928$2,002,928 ▲67.7%335,3331.2%MedicalABBVAbbVie$4,688,019$928,100 ▼-16.5%25,2561.1%MedicalGSKGSK$4,684,800$307,200 ▼-6.2%122,0001.1%MedicalNVSNovartis$4,477,370$1,573,130 ▼-26.0%37,0001.1%MedicalTRVITrevi Therapeutics$4,375,765$4,375,765 ▲New Holding799,9571.0%MedicalMAZE THERAPEUTICS INC$4,373,678$11,031 ▲0.3%356,4531.0%COMANNXAnnexon$4,234,5290.0%1,764,3871.0%MedicalTLTiShares 20+ Year Treasury Bond ETF$4,147,750$18,364,825 ▼-81.6%47,0001.0%ETFIMVTImmunovant$4,107,888$993,680 ▲31.9%256,7431.0%MedicalORICOric Pharmaceuticals$4,006,134$1,622,569 ▲68.1%394,6930.9%MedicalMRKMerck & Co., Inc.$3,847,176$870,760 ▼-18.5%48,6000.9%MedicalACADACADIA Pharmaceuticals$3,772,593$3,772,593 ▲New Holding174,9000.9%MedicalRNAAvidity Biosciences$3,578,400$568,000 ▲18.9%126,0000.8%MedicalALPHA COGNITION INC$3,514,135$2,055,800 ▼-36.9%376,6490.8%COM NEWRZLTRezolute$3,351,454$1,471,800 ▼-30.5%751,4470.8%MedicalCYBIN INC$3,341,812$1,081,580 ▼-24.5%398,3090.8%COM NEWAMATApplied Materials$3,295,2600.0%18,0000.8%Computer and TechnologyARWRArrowhead Pharmaceuticals$3,207,337$1,177,953 ▼-26.9%202,9960.8%MedicalIMTXImmatics$3,137,105$1,818,472 ▼-36.7%583,1050.7%MedicalSVRASavara$2,987,331$59,467 ▲2.0%1,310,2330.7%MedicalUBERUber Technologies$2,799,0000.0%30,0000.7%Computer and TechnologyCAMTCamtek$2,703,891$751,739 ▲38.5%31,9760.6%Computer and TechnologyESLTElbit Systems$2,697,000$2,697,000 ▲New Holding6,0000.6%AerospacePANWPalo Alto Networks$2,683,649$2,683,649 ▲New Holding13,1140.6%Computer and TechnologyWIXWix.com$2,682,886$1,288,438 ▲92.4%16,9310.6%Computer and TechnologyAMGNAmgen$2,652,495$139,605 ▼-5.0%9,5000.6%MedicalSEDGSolarEdge Technologies$2,610,506$3,697,499 ▼-58.6%127,9660.6%EnergyELVNEnliven Therapeutics$2,578,011$336,446 ▲15.0%128,5150.6%MedicalCOGTCogent Biosciences$2,467,716$62,243 ▲2.6%343,6930.6%MedicalSKYE BIOSCIENCE INC$2,250,654$3,920,501 ▼-63.5%538,4340.5%COM NEWDYNE THERAPEUTICS INC$2,107,880$1,026,694 ▼-32.8%221,4160.5%COMPFEPfizer$2,084,640$96,960 ▼-4.4%86,0000.5%MedicalBHVNBiohaven$2,051,199$643,247 ▲45.7%145,3720.5%MedicalSRRKScholar Rock$2,036,544$733,052 ▼-26.5%57,4970.5%MedicalETNB89BIO$2,019,729$4,052,401 ▼-66.7%205,6750.5%MedicalGPCRStructure Therapeutics$1,989,609$247,449 ▲14.2%95,9310.5%MedicalJANXJanux Therapeutics$1,982,904$924,000 ▼-31.8%85,8400.5%MedicalAPLSApellis Pharmaceuticals$1,979,329$1,159,770 ▼-36.9%114,3460.5%MedicalCRMSalesforce$1,854,292$627,187 ▼-25.3%6,8000.4%Computer and TechnologyENGENE HOLDINGS INC$1,836,049$87,200 ▼-4.5%504,4090.4%COMCYBRCyberArk Software$1,627,520$1,627,520 ▲New Holding4,0000.4%Computer and TechnologyMRVLMarvell Technology$1,449,702$283,284 ▲24.3%18,7300.3%Computer and TechnologyATXSAstria Therapeutics$1,379,675$362,347 ▲35.6%257,4020.3%MedicalKURAKura Oncology$1,358,962$623,160 ▼-31.4%235,5220.3%MedicalISHARES BITCOIN TRUST ETF$1,313,261$814,399 ▲163.3%21,4550.3%SHS BEN INTNTLAIntellia Therapeutics$1,207,956$2,366,573 ▼-66.2%128,7800.3%MedicalVTYXVentyx Biosciences$1,189,442$977,841 ▼-45.1%555,8140.3%MedicalAMDAdvanced Micro Devices$1,170,675$1,170,675 ▲New Holding8,2500.3%Computer and TechnologyNNDMNano Dimension$1,162,3790.0%717,5180.3%Computer and TechnologyDAWNDay One Biopharmaceuticals$1,139,912$1,037,504 ▼-47.6%175,3710.3%MedicalCEVACeva$1,075,2620.0%48,9200.3%Computer and TechnologyPERSPECTIVE THERAPEUTICS INC$1,067,580$515,670 ▼-32.6%310,3430.3%COM NEWKRYSKrystal Biotech$1,008,269$1,008,269 ▲New Holding7,3350.2%MedicalTSHATaysha Gene Therapies$970,200$970,200 ▲New Holding420,0000.2%MedicalPMNPromis Neurosciences$918,880$14,514 ▼-1.6%1,899,2970.2%MedicalVTGNVistaGen Therapeutics$895,878$685,222 ▼-43.3%447,9390.2%MedicalCMMBChemomab Therapeutics$856,136$188,361 ▼-18.0%738,0480.2%MedicalBMYBristol Myers Squibb$810,075$115,725 ▼-12.5%17,5000.2%MedicalCRVSCorvus Pharmaceuticals$732,376$91,060 ▼-11.1%183,0940.2%MedicalHOWLWerewolf Therapeutics$683,2230.0%626,8100.2%MedicalVSTMVerastem$677,724$677,724 ▲New Holding163,3070.2%MedicalBICARA THERAPEUTICS INC$610,158$610,158 ▲New Holding65,6790.1%COMLRMRLarimar Therapeutics$568,275$490,343 ▼-46.3%196,6350.1%MedicalSSentinelOne$493,560$493,560 ▲New Holding27,0000.1%Computer and TechnologyAPREAprea Therapeutics$456,3000.0%270,0000.1%MedicalCGNTCognyte Software$417,472$417,472 ▲New Holding45,1810.1%Computer and TechnologyKEZAR LIFE SCIENCES INC$268,109$228,698 ▼-46.0%58,5390.1%COM NEWELYMEliem Therapeutics$260,198$39,802 ▼-13.3%209,8370.1%MedicalSLDBSolid Biosciences$244,425$244,425 ▲New Holding50,1900.1%MedicalPEPGPepGen$173,678$173,678 ▲New Holding156,4670.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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