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OnKure Therapeutics (OKUR) Competitors

OnKure Therapeutics logo
$4.58 0.00 (0.00%)
Closing price 07/2/2026 04:00 PM Eastern
Extended Trading
$4.58 +0.00 (+0.11%)
As of 07/2/2026 04:10 PM Eastern
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OKUR vs. GYRE, AURA, EIKN, ACRS, and FDMT

Should you buy OnKure Therapeutics stock or one of its competitors? MarketBeat compares OnKure Therapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with OnKure Therapeutics include Gyre Therapeutics (GYRE), Aura Biosciences (AURA), Eikon Therapeutics (EIKN), Aclaris Therapeutics (ACRS), and 4D Molecular Therapeutics (FDMT). These companies are all part of the "pharmaceutical products" industry.

How does OnKure Therapeutics compare to Gyre Therapeutics?

OnKure Therapeutics (NASDAQ:OKUR) and Gyre Therapeutics (NASDAQ:GYRE) are both small-cap medical companies, but which is the superior stock? We will contrast the two businesses based on the strength of their risk, earnings, valuation, institutional ownership, media sentiment, analyst recommendations, dividends and profitability.

Gyre Therapeutics has higher revenue and earnings than OnKure Therapeutics. Gyre Therapeutics is trading at a lower price-to-earnings ratio than OnKure Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
OnKure TherapeuticsN/AN/A-$59.52M-$4.33N/A
Gyre Therapeutics$117.05M6.99$5.03M-$0.09N/A

OnKure Therapeutics has a net margin of 0.00% compared to Gyre Therapeutics' net margin of -5.44%. Gyre Therapeutics' return on equity of 3.13% beat OnKure Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
OnKure TherapeuticsN/A -61.02% -55.99%
Gyre Therapeutics -5.44%3.13%2.67%

91.0% of OnKure Therapeutics shares are held by institutional investors. Comparatively, 24.0% of Gyre Therapeutics shares are held by institutional investors. 2.3% of OnKure Therapeutics shares are held by company insiders. Comparatively, 9.5% of Gyre Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

In the previous week, OnKure Therapeutics had 2 more articles in the media than Gyre Therapeutics. MarketBeat recorded 2 mentions for OnKure Therapeutics and 0 mentions for Gyre Therapeutics. OnKure Therapeutics' average media sentiment score of 0.00 equaled Gyre Therapeutics'average media sentiment score.

Company Overall Sentiment
OnKure Therapeutics Neutral
Gyre Therapeutics Neutral

OnKure Therapeutics presently has a consensus price target of $27.00, indicating a potential upside of 489.52%. Gyre Therapeutics has a consensus price target of $17.00, indicating a potential upside of 131.61%. Given OnKure Therapeutics' higher possible upside, equities analysts clearly believe OnKure Therapeutics is more favorable than Gyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
OnKure Therapeutics
1 Sell rating(s)
2 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Gyre Therapeutics
2 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.00

OnKure Therapeutics has a beta of 0.27, suggesting that its stock price is 73% less volatile than the broader market. Comparatively, Gyre Therapeutics has a beta of 1.89, suggesting that its stock price is 89% more volatile than the broader market.

Summary

Gyre Therapeutics beats OnKure Therapeutics on 8 of the 13 factors compared between the two stocks.

How does OnKure Therapeutics compare to Aura Biosciences?

Aura Biosciences (NASDAQ:AURA) and OnKure Therapeutics (NASDAQ:OKUR) are both small-cap medical companies, but which is the superior business? We will contrast the two businesses based on the strength of their institutional ownership, media sentiment, risk, profitability, analyst recommendations, valuation, earnings and dividends.

Aura Biosciences is trading at a lower price-to-earnings ratio than OnKure Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Aura BiosciencesN/AN/A-$106.19M-$1.74N/A
OnKure TherapeuticsN/AN/A-$59.52M-$4.33N/A

Aura Biosciences presently has a consensus target price of $20.50, indicating a potential upside of 164.86%. OnKure Therapeutics has a consensus target price of $27.00, indicating a potential upside of 489.52%. Given OnKure Therapeutics' higher probable upside, analysts plainly believe OnKure Therapeutics is more favorable than Aura Biosciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Aura Biosciences
1 Sell rating(s)
1 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.25
OnKure Therapeutics
1 Sell rating(s)
2 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00

OnKure Therapeutics' return on equity of -61.02% beat Aura Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Aura BiosciencesN/A -78.12% -64.08%
OnKure Therapeutics N/A -61.02%-55.99%

In the previous week, OnKure Therapeutics had 1 more articles in the media than Aura Biosciences. MarketBeat recorded 2 mentions for OnKure Therapeutics and 1 mentions for Aura Biosciences. Aura Biosciences' average media sentiment score of 1.97 beat OnKure Therapeutics' score of 0.00 indicating that Aura Biosciences is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Aura Biosciences
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
OnKure Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

96.8% of Aura Biosciences shares are owned by institutional investors. Comparatively, 91.0% of OnKure Therapeutics shares are owned by institutional investors. 1.9% of Aura Biosciences shares are owned by insiders. Comparatively, 2.3% of OnKure Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term.

Aura Biosciences has a beta of 0.4, indicating that its stock price is 60% less volatile than the broader market. Comparatively, OnKure Therapeutics has a beta of 0.27, indicating that its stock price is 73% less volatile than the broader market.

Summary

OnKure Therapeutics beats Aura Biosciences on 7 of the 13 factors compared between the two stocks.

How does OnKure Therapeutics compare to Eikon Therapeutics?

OnKure Therapeutics (NASDAQ:OKUR) and Eikon Therapeutics (NASDAQ:EIKN) are both small-cap pharmaceutical products companies, but which is the better business? We will contrast the two companies based on the strength of their profitability, dividends, analyst recommendations, institutional ownership, valuation, risk, earnings and media sentiment.

OnKure Therapeutics presently has a consensus target price of $27.00, indicating a potential upside of 489.52%. Eikon Therapeutics has a consensus target price of $25.20, indicating a potential upside of 100.96%. Given OnKure Therapeutics' higher probable upside, equities research analysts plainly believe OnKure Therapeutics is more favorable than Eikon Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
OnKure Therapeutics
1 Sell rating(s)
2 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Eikon Therapeutics
2 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.38

Eikon Therapeutics' return on equity of 0.00% beat OnKure Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
OnKure TherapeuticsN/A -61.02% -55.99%
Eikon Therapeutics N/A N/A N/A

91.0% of OnKure Therapeutics shares are held by institutional investors. 2.3% of OnKure Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

In the previous week, OnKure Therapeutics had 1 more articles in the media than Eikon Therapeutics. MarketBeat recorded 2 mentions for OnKure Therapeutics and 1 mentions for Eikon Therapeutics. Eikon Therapeutics' average media sentiment score of 1.86 beat OnKure Therapeutics' score of 0.00 indicating that Eikon Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
OnKure Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Eikon Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

Eikon Therapeutics is trading at a lower price-to-earnings ratio than OnKure Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
OnKure TherapeuticsN/AN/A-$59.52M-$4.33N/A
Eikon TherapeuticsN/AN/AN/A-$2.46N/A

Summary

Eikon Therapeutics beats OnKure Therapeutics on 6 of the 11 factors compared between the two stocks.

How does OnKure Therapeutics compare to Aclaris Therapeutics?

OnKure Therapeutics (NASDAQ:OKUR) and Aclaris Therapeutics (NASDAQ:ACRS) are both small-cap medical companies, but which is the better investment? We will compare the two businesses based on the strength of their media sentiment, risk, profitability, dividends, analyst recommendations, earnings, institutional ownership and valuation.

OnKure Therapeutics has a beta of 0.27, meaning that its stock price is 73% less volatile than the broader market. Comparatively, Aclaris Therapeutics has a beta of 0.76, meaning that its stock price is 24% less volatile than the broader market.

OnKure Therapeutics has a net margin of 0.00% compared to Aclaris Therapeutics' net margin of -832.58%. Aclaris Therapeutics' return on equity of -55.89% beat OnKure Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
OnKure TherapeuticsN/A -61.02% -55.99%
Aclaris Therapeutics -832.58%-55.89%-38.49%

In the previous week, OnKure Therapeutics had 1 more articles in the media than Aclaris Therapeutics. MarketBeat recorded 2 mentions for OnKure Therapeutics and 1 mentions for Aclaris Therapeutics. Aclaris Therapeutics' average media sentiment score of 0.50 beat OnKure Therapeutics' score of 0.00 indicating that Aclaris Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
OnKure Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Aclaris Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

91.0% of OnKure Therapeutics shares are owned by institutional investors. Comparatively, 98.3% of Aclaris Therapeutics shares are owned by institutional investors. 2.3% of OnKure Therapeutics shares are owned by company insiders. Comparatively, 4.8% of Aclaris Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

OnKure Therapeutics has higher earnings, but lower revenue than Aclaris Therapeutics. Aclaris Therapeutics is trading at a lower price-to-earnings ratio than OnKure Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
OnKure TherapeuticsN/AN/A-$59.52M-$4.33N/A
Aclaris Therapeutics$8.37M92.81-$64.92M-$0.56N/A

OnKure Therapeutics currently has a consensus price target of $27.00, suggesting a potential upside of 489.52%. Aclaris Therapeutics has a consensus price target of $11.50, suggesting a potential upside of 106.83%. Given OnKure Therapeutics' higher probable upside, research analysts plainly believe OnKure Therapeutics is more favorable than Aclaris Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
OnKure Therapeutics
1 Sell rating(s)
2 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Aclaris Therapeutics
1 Sell rating(s)
0 Hold rating(s)
4 Buy rating(s)
3 Strong Buy rating(s)
3.13

Summary

Aclaris Therapeutics beats OnKure Therapeutics on 11 of the 16 factors compared between the two stocks.

How does OnKure Therapeutics compare to 4D Molecular Therapeutics?

OnKure Therapeutics (NASDAQ:OKUR) and 4D Molecular Therapeutics (NASDAQ:FDMT) are both small-cap medical companies, but which is the better stock? We will contrast the two companies based on the strength of their analyst recommendations, valuation, institutional ownership, risk, media sentiment, earnings, dividends and profitability.

91.0% of OnKure Therapeutics shares are held by institutional investors. Comparatively, 99.3% of 4D Molecular Therapeutics shares are held by institutional investors. 2.3% of OnKure Therapeutics shares are held by insiders. Comparatively, 7.9% of 4D Molecular Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth.

OnKure Therapeutics has a beta of 0.27, indicating that its share price is 73% less volatile than the broader market. Comparatively, 4D Molecular Therapeutics has a beta of 2.7, indicating that its share price is 170% more volatile than the broader market.

OnKure Therapeutics has higher earnings, but lower revenue than 4D Molecular Therapeutics. 4D Molecular Therapeutics is trading at a lower price-to-earnings ratio than OnKure Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
OnKure TherapeuticsN/AN/A-$59.52M-$4.33N/A
4D Molecular Therapeutics$85.21M7.98-$140.11M-$2.57N/A

OnKure Therapeutics currently has a consensus price target of $27.00, indicating a potential upside of 489.52%. 4D Molecular Therapeutics has a consensus price target of $29.88, indicating a potential upside of 129.81%. Given OnKure Therapeutics' higher probable upside, analysts plainly believe OnKure Therapeutics is more favorable than 4D Molecular Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
OnKure Therapeutics
1 Sell rating(s)
2 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
4D Molecular Therapeutics
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.67

OnKure Therapeutics has a net margin of 0.00% compared to 4D Molecular Therapeutics' net margin of -182.34%. 4D Molecular Therapeutics' return on equity of -36.83% beat OnKure Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
OnKure TherapeuticsN/A -61.02% -55.99%
4D Molecular Therapeutics -182.34%-36.83%-32.55%

In the previous week, 4D Molecular Therapeutics had 7 more articles in the media than OnKure Therapeutics. MarketBeat recorded 9 mentions for 4D Molecular Therapeutics and 2 mentions for OnKure Therapeutics. 4D Molecular Therapeutics' average media sentiment score of 0.36 beat OnKure Therapeutics' score of 0.00 indicating that 4D Molecular Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
OnKure Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
4D Molecular Therapeutics
2 Very Positive mention(s)
1 Positive mention(s)
6 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

4D Molecular Therapeutics beats OnKure Therapeutics on 11 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding OKUR and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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OKUR vs. The Competition

MetricOnKure TherapeuticsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$185.01M$3.78B$7.16B$12.48B
Dividend YieldN/A2.16%2.66%6.52%
P/E Ratio-1.0621.6128.0224.70
Price / SalesN/A340.19540.3799.49
Price / CashN/A147.1249.2657.09
Price / Book1.118.6610.966.46
Net Income-$59.52M$23.81M$3.57B$337.01M
7 Day Performance1.78%3.39%2.12%1.69%
1 Month Performance9.31%10.81%5.25%3.81%
1 Year Performance90.83%62.61%33.29%23.90%

OnKure Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
OKUR
OnKure Therapeutics
2.141 of 5 stars
$4.58
flat
$27.00
+489.5%
+90.8%$185.01MN/AN/AN/A
GYRE
Gyre Therapeutics
1.7971 of 5 stars
$6.59
+2.2%
$17.00
+158.0%
-9.8%$719.10M$116.59MN/A40
AURA
Aura Biosciences
2.2934 of 5 stars
$7.10
+3.2%
$20.50
+188.7%
+17.5%$711.30MN/AN/A50
EIKN
Eikon Therapeutics
2.3788 of 5 stars
$13.05
+2.4%
$25.20
+93.1%
N/A$706.51MN/AN/A384
ACRS
Aclaris Therapeutics
3.179 of 5 stars
$5.29
+5.4%
$11.50
+117.4%
+284.8%$701.11M$7.83MN/A100

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This page (NASDAQ:OKUR) was last updated on 7/5/2026 by MarketBeat.com Staff.
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