Spero Therapeutics (SPRO) Stock Chart & Stock Price History $0.69 +0.01 (+0.82%) Closing price 05/21/2025 04:00 PM EasternExtended Trading$0.68 -0.01 (-0.99%) As of 05/21/2025 07:20 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Spero Therapeutics Stock Price Performance The Spero Therapeutics (SPRO) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has decreased 54.43%, with a year-to-date return of -33.42%. In the past month, the stock has decreased 6.34%, reflecting recent market activity. As of the latest close, Spero Therapeutics traded at $0.69 with a market cap of $38.34 million and volume of 86,477 shares. Five years ago, the stock traded at $12.50, representing a 94.51% decrease over that period. At the time, it had a market cap of $249.76 million and a volume of 221,912 shares. Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Email Address 5 Day Performance+5.35%1 Month Performance-6.34%3 Month Performance-17.47%Year-To-Date Performance-33.42%1 Year Performance-54.43%5 Year Performance-94.51% SPRO Stock Chart for Thursday, May, 22, 2025 SPRO Chart by TradingView Spero Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame * Start Date * End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization05/21/2025$0.68$0.69+0.82%$0.71$0.6886,477 shs$38.34 million05/20/2025$0.69$0.68-1.32%$0.70$0.6765,394 shs$38.03 million05/19/2025$0.65$0.69+5.88%$0.70$0.6599,298 shs$38.54 million05/16/2025$0.65$0.65-0.03%$0.68$0.6389,381 shs$36.40 million05/15/2025$0.65$0.65+0.17%$0.69$0.63119,549 shs$36.41 million05/14/2025$0.69$0.65-5.78%$0.70$0.6565,572 shs$36.35 million05/13/2025$0.61$0.69+13.11%$0.70$0.61286,803 shs$38.58 million05/12/2025$0.62$0.61-1.61%$0.64$0.60144,933 shs$34.11 million05/09/2025$0.58$0.62+7.83%$0.64$0.5781,453 shs$34.67 million05/08/2025$0.58$0.58-0.52%$0.61$0.58183,470 shs$32.15 million Get the Latest News and Ratings for SPRO and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 05/07/2025$0.59$0.58-2.03%$0.60$0.5857,128 shs$32.32 million05/06/2025$0.61$0.59-3.28%$0.64$0.5994,557 shs$32.99 million05/05/2025$0.65$0.61-5.72%$0.67$0.61107,193 shs$34.11 million05/02/2025$0.66$0.65-1.97%$0.67$0.6485,215 shs$36.17 million05/01/2025$0.66$0.66+0.30%$0.68$0.6627,448 shs$36.90 million04/30/2025$0.67$0.66-1.94%$0.69$0.6479,293 shs$36.78 million04/29/2025$0.71$0.67-5.49%$0.72$0.6752,340 shs$37.51 million04/28/2025$0.73$0.71-2.10%$0.74$0.7146,508 shs$39.69 million04/25/2025$0.73$0.73+0.03%$0.75$0.7371,847 shs$40.54 million04/24/2025$0.73$0.73-0.29%$0.74$0.7228,949 shs$40.53 million04/23/2025$0.73$0.73-0.70%$0.76$0.63246,771 shs$40.65 million04/22/2025$0.73$0.73+0.99%$0.78$0.7297,664 shs$40.93 million04/21/2025$0.75$0.73-3.87%$0.78$0.7325,518 shs$40.53 million Related Companies Aclaris Therapeutics Stock Price Chart ADC Therapeutics Stock Price Chart Larimar Therapeutics Stock Price Chart Editas Medicine Stock Price Chart Greenwich LifeSciences Stock Price Chart Protara Therapeutics Stock Price Chart scPharmaceuticals Stock Price Chart Lyell Immunopharma Stock Price Chart Tonix Pharmaceuticals Stock Price Chart Fate Therapeutics Stock Price Chart Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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