Spero Therapeutics (SPRO) Stock Chart & Stock Price History $2.33 -0.02 (-0.85%) Closing price 07/25/2025 04:00 PM EasternExtended Trading$2.33 0.00 (0.00%) As of 07/25/2025 05:24 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Spero Therapeutics Stock Price Performance The Spero Therapeutics (SPRO) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has increased 62.37%, with a year-to-date return of 126.21%. In the past month, the stock has decreased 19.66%, reflecting recent market activity. As of the latest close, Spero Therapeutics traded at $2.33 with a market cap of $130.27 million and volume of 350,749 shares. Five years ago, the stock traded at $12.12, representing a 80.78% decrease over that period. At the time, it had a market cap of $250.37 million and a volume of 85,712 shares. Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Email Address 5 Day Performance+0.43%1 Month Performance-19.66%3 Month Performance+221.29%Year-To-Date Performance+126.21%1 Year Performance+62.37%5 Year Performance-80.78% SPRO Stock Chart for Saturday, July, 26, 2025 SPRO Chart by TradingView Spero Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization07/25/2025$2.35$2.33-0.85%$2.40$2.32350,749 shs$130.27 million07/24/2025$2.38$2.35-1.26%$2.41$2.35368,489 shs$131.39 million07/23/2025$2.41$2.38-1.24%$2.45$2.37656,677 shs$133.07 million07/22/2025$2.32$2.41+3.88%$2.45$2.32552,623 shs$134.75 million07/21/2025$2.37$2.32-2.11%$2.41$2.30534,870 shs$129.71 million07/18/2025$2.48$2.37-4.44%$2.53$2.35969,965 shs$132.51 million07/17/2025$2.47$2.48+0.40%$2.51$2.47500,806 shs$138.66 million07/16/2025$2.49$2.47-0.80%$2.52$2.45865,146 shs$138.10 million07/15/2025$2.64$2.49-5.68%$2.63$2.471.02 million shs$139.22 million07/14/2025$2.81$2.64-6.05%$2.84$2.61909,238 shs$147.60 million Get the Latest News and Ratings for SPRO and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 07/11/2025$2.84$2.81-1.06%$2.90$2.76989,807 shs$157.11 million07/10/2025$3.04$2.84-6.58%$3.07$2.831.84 million shs$158.78 million07/09/2025$2.94$3.04+3.40%$3.22$2.951.72 million shs$164.38 million07/08/2025$2.90$2.94+1.38%$3.00$2.89629,953 shs$164.38 million07/07/2025$2.91$2.90-0.34%$2.94$2.90844,769 shs$162.14 million07/04/2025$2.91$2.91$2.94$2.90390,072 shs$162.70 million07/03/2025$2.90$2.91+0.34%$2.94$2.90390,072 shs$162.70 million07/02/2025$2.90$2.90$3.03$2.901.10 million shs$162.14 million07/01/2025$2.90$2.90$2.95$2.90639,760 shs$162.14 million06/30/2025$2.94$2.90-1.36%$3.00$2.901.15 million shs$162.14 million06/27/2025$2.90$2.94+1.38%$3.09$2.901.69 million shs$164.38 million06/26/2025$2.90$2.90$2.94$2.87557,949 shs$162.14 million06/25/2025$2.88$2.90+0.69%$2.93$2.791.46 million shs$162.14 million Related Companies Opthea Stock Price Chart Precigen Stock Price Chart Solid Biosciences Stock Price Chart Terns Pharmaceuticals Stock Price Chart Tourmaline Bio Stock Price Chart PureTech Health Stock Price Chart Siga Technologies Stock Price Chart Rezolute Stock Price Chart Cullinan Therapeutics Stock Price Chart Kamada Stock Price Chart Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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