Spero Therapeutics (SPRO) Stock Chart & Stock Price History $1.96 -0.02 (-0.76%) As of 01:32 PM Eastern This is a fair market value price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Spero Therapeutics Stock Price Performance The Spero Therapeutics (SPRO) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has increased 52.73%, with a year-to-date return of 89.81%. In the past month, the stock has increased 5.68%, reflecting recent market activity. As of the latest close, Spero Therapeutics traded at $1.97 with a market cap of $110.87 million and volume of 254,487 shares. Five years ago, the stock traded at $9.53, representing a 79.49% decrease over that period. At the time, it had a market cap of $201.59 million and a volume of 146,010 shares. Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. 5 Day Performance-2.25%1 Month Performance+5.68%3 Month Performance-32.59%Year-To-Date Performance+89.81%1 Year Performance+52.73%5 Year Performance-79.49% SPRO Stock Chart for Thursday, September, 25, 2025 SPRO Chart by TradingView Spero Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization09/24/2025$2.01$1.97-1.99%$2.04$1.97254,487 shs$110.87 million09/23/2025$2.03$2.01-0.99%$2.05$1.98192,982 shs$113.12 million09/22/2025$2.00$2.03+1.50%$2.03$1.97345,786 shs$114.24 million09/19/2025$2.00$2.00$2.05$1.96393,615 shs$112.55 million09/18/2025$1.90$2.00+5.26%$2.01$1.90272,991 shs$112.56 million09/17/2025$1.90$1.90$1.95$1.89148,467 shs$106.93 million09/16/2025$1.88$1.90+1.06%$1.91$1.87133,679 shs$106.92 million09/15/2025$1.90$1.88-1.05%$1.92$1.87289,435 shs$105.81 million09/12/2025$1.95$1.90-2.56%$1.99$1.89391,231 shs$106.93 million09/11/2025$1.94$1.95+0.52%$2.02$1.94286,585 shs$109.75 million Get the Latest News and Ratings for SPRO and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 09/10/2025$1.98$1.94-2.02%$2.02$1.91357,306 shs$109.17 million09/09/2025$2.00$1.98-1.00%$2.01$1.94222,566 shs$111.43 million09/08/2025$2.15$2.00-6.98%$2.18$1.86518,968 shs$112.56 million09/05/2025$2.14$2.15+0.47%$2.17$2.13175,498 shs$121.00 million09/04/2025$2.08$2.14+2.88%$2.20$2.07520,609 shs$120.44 million09/03/2025$2.05$2.08+1.46%$2.12$2.04291,283 shs$117.05 million09/02/2025$2.07$2.05-0.97%$2.12$2.03416,916 shs$115.37 million09/01/2025$2.07$2.07$2.07$2.00395,346 shs$116.50 million08/29/2025$2.00$2.07+3.50%$2.07$2.00395,346 shs$116.50 million08/28/2025$1.98$2.00+1.01%$2.04$1.96254,895 shs$112.55 million08/27/2025$1.85$1.98+7.03%$2.01$1.85554,715 shs$111.43 million08/26/2025$1.85$1.85$1.88$1.83161,205 shs$104.12 million08/25/2025$1.87$1.85-1.07%$1.90$1.85185,297 shs$104.11 million Related Companies REGENXBIO Stock Price Chart iTeos Therapeutics Stock Price Chart Corvus Pharmaceuticals Stock Price Chart Zhengye Biotechnology Stock Price Chart Prothena Stock Price Chart Alumis Stock Price Chart Zevra Therapeutics Stock Price Chart Flag Ship Acquisition Stock Price Chart Evolus Stock Price Chart Inhibrx Biosciences Stock Price Chart Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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