Spero Therapeutics (SPRO) Stock Chart & Stock Price History $1.91 -0.07 (-3.54%) Closing price 04:00 PM EasternExtended Trading$1.91 0.00 (0.00%) As of 04:10 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Spero Therapeutics Stock Price Performance The Spero Therapeutics (SPRO) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has increased 57.85%, with a year-to-date return of 85.44%. In the past month, the stock has decreased 23.29%, reflecting recent market activity. As of the latest close, Spero Therapeutics traded at $1.98 with a market cap of $110.70 million and volume of 625,315 shares. Five years ago, the stock traded at $12.50, representing a 84.72% decrease over that period. At the time, it had a market cap of $278.33 million and a volume of 6,942 shares. Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Email Address 5 Day Performance-12.79%1 Month Performance-23.29%3 Month Performance+193.30%Year-To-Date Performance+85.44%1 Year Performance+57.85%5 Year Performance-84.72% SPRO Stock Chart for Friday, August, 15, 2025 SPRO Chart by TradingView Spero Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization08/14/2025$1.93$1.98+2.59%$2.01$1.92625,315 shs$110.70 million08/13/2025$2.36$1.93-18.22%$2.15$1.922.49 million shs$107.91 million08/12/2025$2.20$2.36+7.27%$2.38$2.21639,539 shs$131.95 million08/11/2025$2.19$2.20+0.46%$2.23$2.15360,239 shs$123.00 million08/08/2025$2.17$2.19+0.92%$2.22$2.16402,052 shs$122.44 million08/07/2025$2.26$2.17-3.98%$2.27$2.131.00 million shs$121.33 million08/06/2025$2.12$2.26+6.60%$2.31$2.15817,652 shs$126.36 million08/05/2025$2.26$2.12-6.19%$2.33$2.112.32 million shs$118.53 million08/04/2025$2.30$2.26-1.74%$2.39$2.20950,256 shs$126.36 million08/01/2025$2.32$2.30-0.86%$2.33$2.22518,730 shs$128.59 million Get the Latest News and Ratings for SPRO and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 07/31/2025$2.17$2.32+6.91%$2.44$2.17915,799 shs$129.71 million07/30/2025$2.20$2.17-1.36%$2.26$2.16483,328 shs$121.33 million07/29/2025$2.30$2.20-4.35%$2.31$2.17879,074 shs$123.00 million07/28/2025$2.33$2.30-1.29%$2.35$2.29295,408 shs$128.60 million07/25/2025$2.35$2.33-0.85%$2.40$2.32350,749 shs$130.27 million07/24/2025$2.38$2.35-1.26%$2.41$2.35368,489 shs$131.39 million07/23/2025$2.41$2.38-1.24%$2.45$2.37656,677 shs$133.07 million07/22/2025$2.32$2.41+3.88%$2.45$2.32552,623 shs$134.75 million07/21/2025$2.37$2.32-2.11%$2.41$2.30534,870 shs$129.71 million07/18/2025$2.48$2.37-4.44%$2.53$2.35969,965 shs$132.51 million07/17/2025$2.47$2.48+0.40%$2.51$2.47500,806 shs$138.66 million07/16/2025$2.49$2.47-0.80%$2.52$2.45865,146 shs$138.10 million07/15/2025$2.64$2.49-5.68%$2.63$2.471.02 million shs$139.22 million07/14/2025$2.81$2.64-6.05%$2.84$2.61909,238 shs$147.60 million Related Companies Solid Biosciences Stock Price Chart Kura Oncology Stock Price Chart Prime Medicine Stock Price Chart Arvinas Stock Price Chart Eton Pharmaceuticals Stock Price Chart Savara Stock Price Chart Palvella Therapeutics Stock Price Chart iTeos Therapeutics Stock Price Chart SNDL Stock Price Chart Cullinan Therapeutics Stock Price Chart Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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