Spero Therapeutics (SPRO) Stock Chart & Stock Price History $2.80 -0.05 (-1.75%) Closing price 04:00 PM EasternExtended Trading$2.81 +0.01 (+0.36%) As of 07:55 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock Spero Therapeutics Stock Price Performance The Spero Therapeutics (SPRO) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has increased 88.55%, with a year-to-date return of 171.84%. In the past month, the stock has increased 351.61%, reflecting recent market activity. As of the latest close, Spero Therapeutics traded at $2.85 with a market cap of $159.35 million and volume of 2.22 million shares. Five years ago, the stock traded at $12.80, representing a 78.13% decrease over that period. At the time, it had a market cap of $256.20 million and a volume of 118,800 shares. Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Email Address 5 Day Performance+12.00%1 Month Performance+351.61%3 Month Performance+279.76%Year-To-Date Performance+171.84%1 Year Performance+88.55%5 Year Performance-78.13% SPRO Stock Chart for Wednesday, June, 11, 2025 SPRO Chart by TradingView Spero Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization06/11/2025$2.85$2.80-1.75%$2.89$2.641.89 million shs$156.55 million06/10/2025$2.76$2.85+3.26%$2.93$2.722.22 million shs$159.35 million06/09/2025$2.50$2.76+10.40%$2.81$2.503.99 million shs$154.31 million06/06/2025$2.56$2.50-2.34%$2.74$2.452.55 million shs$139.78 million06/05/2025$2.66$2.56-3.76%$2.69$2.521.70 million shs$143.13 million06/04/2025$2.64$2.66+0.76%$2.90$2.472.65 million shs$148.72 million06/03/2025$2.74$2.64-3.65%$2.78$2.552.10 million shs$147.61 million06/02/2025$2.58$2.74+6.20%$2.95$2.426.58 million shs$153.20 million05/30/2025$2.13$2.58+21.13%$2.80$2.3524.29 million shs$144.25 million05/29/2025$2.35$2.13-9.36%$2.34$2.107.33 million shs$119.09 million Get the Latest News and Ratings for SPRO and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 05/28/2025$0.68$2.35+244.57%$2.48$1.85182.84 million shs$131.39 million05/27/2025$0.70$0.68-2.05%$0.70$0.6668,596 shs$38.13 million05/26/2025$0.70$0.70$0.70$0.6740,431 shs$38.93 million05/23/2025$0.70$0.70-0.24%$0.70$0.6740,431 shs$38.93 million05/22/2025$0.69$0.70+1.78%$0.71$0.6630,245 shs$39.03 million05/21/2025$0.68$0.69+0.82%$0.71$0.6886,477 shs$38.34 million05/20/2025$0.69$0.68-1.32%$0.70$0.6765,394 shs$38.03 million05/19/2025$0.65$0.69+5.88%$0.70$0.6599,298 shs$38.54 million05/16/2025$0.65$0.65-0.03%$0.68$0.6389,381 shs$36.40 million05/15/2025$0.65$0.65+0.17%$0.69$0.63119,549 shs$36.41 million05/14/2025$0.69$0.65-5.78%$0.70$0.6565,572 shs$36.35 million05/13/2025$0.61$0.69+13.11%$0.70$0.61286,803 shs$38.58 million05/12/2025$0.62$0.61-1.61%$0.64$0.60144,933 shs$34.11 million Related Companies ChromaDex Stock Price Chart Xencor Stock Price Chart ORIC Pharmaceuticals Stock Price Chart GH Research Stock Price Chart Taysha Gene Therapies Stock Price Chart Keros Therapeutics Stock Price Chart Bicycle Therapeutics Stock Price Chart Iovance Biotherapeutics Stock Price Chart Upstream Bio Stock Price Chart VectivBio Stock Price Chart Receive SPRO Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spero Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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