Spyre Therapeutics (SYRE) Stock Chart & Stock Price History $15.16 -0.08 (-0.52%) Closing price 04:00 PM EasternExtended Trading$15.00 -0.16 (-1.06%) As of 04:10 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock Spyre Therapeutics Stock Price Performance The Spyre Therapeutics (SYRE) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has decreased 39.96%, with a year-to-date return of -34.88%. In the past month, the stock has decreased 2.88%, reflecting recent market activity. As of the latest close, Spyre Therapeutics traded at $15.24 with a market cap of $918.61 million and volume of 417,085 shares. Receive SYRE Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spyre Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Email Address 5 Day Performance-6.77%1 Month Performance-2.88%3 Month Performance+17.80%Year-To-Date Performance-34.88%1 Year Performance-39.96% SYRE Stock Chart for Friday, August, 8, 2025 SYRE Chart by TradingView Spyre Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization08/07/2025$15.96$15.24-4.51%$15.90$14.94417,085 shs$918.61 million08/06/2025$16.87$15.96-5.39%$16.88$15.66631,443 shs$962.07 million08/05/2025$16.16$16.87+4.39%$16.99$15.97363,483 shs$1.02 billion08/04/2025$16.26$16.16-0.62%$17.01$15.81728,922 shs$974.06 million08/01/2025$16.97$16.26-4.18%$17.04$16.23551,674 shs$980.09 million07/31/2025$17.29$16.97-1.85%$17.32$16.57599,802 shs$1.02 billion07/30/2025$16.77$17.29+3.10%$17.70$16.78884,505 shs$1.04 billion07/29/2025$16.98$16.77-1.24%$17.20$16.42472,722 shs$1.01 billion07/28/2025$17.79$16.98-4.55%$18.00$16.84641,898 shs$1.02 billion07/25/2025$17.60$17.79+1.08%$17.95$17.06841,400 shs$1.07 billion Get the Latest News and Ratings for SYRE and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Spyre Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 07/24/2025$17.81$17.60-1.18%$18.31$17.38541,165 shs$1.06 billion07/23/2025$16.49$17.81+8.00%$18.03$16.53339,746 shs$1.07 billion07/22/2025$16.35$16.49+0.86%$16.73$16.16654,412 shs$994.02 million07/21/2025$16.29$16.35+0.37%$17.08$16.23513,550 shs$985.58 million07/18/2025$16.89$16.29-3.55%$17.19$16.08333,165 shs$981.96 million07/17/2025$16.20$16.89+4.26%$16.90$16.22475,304 shs$1.02 billion07/16/2025$15.31$16.20+5.81%$16.27$15.44382,463 shs$976.47 million07/15/2025$16.41$15.31-6.70%$17.09$15.05703,584 shs$922.89 million07/14/2025$15.69$16.41+4.59%$16.56$15.61520,177 shs$989.20 million07/11/2025$15.96$15.69-1.69%$15.96$15.47491,411 shs$945.79 million07/10/2025$16.55$15.96-3.56%$16.57$15.83482,877 shs$962.01 million07/09/2025$15.61$16.55+6.02%$16.92$15.79566,300 shs$997.63 million07/08/2025$15.30$15.61+2.03%$16.10$15.37555,714 shs$940.97 million07/07/2025$15.84$15.30-3.41%$15.84$14.97804,594 shs$922.28 million Related Companies ACLX Stock Chart AKRO Stock Chart VKTX Stock Chart MTSR Stock Chart SWTX Stock Chart SRRK Stock Chart MLTX Stock Chart PTGX Stock Chart AAPG Stock Chart HCM Stock Chart Receive SYRE Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spyre Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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