Spyre Therapeutics (SYRE) Stock Chart & Stock Price History $16.72 -0.42 (-2.45%) Closing price 08/28/2025 04:00 PM EasternExtended Trading$16.65 -0.07 (-0.42%) As of 08/28/2025 04:25 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Chart Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock Spyre Therapeutics Stock Price Performance The Spyre Therapeutics (SYRE) stock chart highlights key performance trends across multiple timeframes. Over the last 12 months, the stock's price has decreased 40.43%, with a year-to-date return of -28.18%. In the past month, the stock has decreased 0.30%, reflecting recent market activity. As of the latest close, Spyre Therapeutics traded at $16.72 with a market cap of $1.01 billion and volume of 298,692 shares. Receive SYRE Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spyre Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. 5 Day Performance-3.80%1 Month Performance-0.30%3 Month Performance+7.52%Year-To-Date Performance-28.18%1 Year Performance-40.43% SYRE Stock Chart for Friday, August, 29, 2025 SYRE Chart by TradingView Spyre Therapeutics Stock Price History Daily Weekly Monthly Yearly Time Frame Custom Range 1 Month 3 Months 6 Months Year-to-Date 1 Year 3 Year 5 Year Time Frame Start Date End Date Export to Excel DateOpening PriceClosing PriceHighLowVolumeMarket Capitalization08/28/2025$17.14$16.72-2.45%$17.39$16.65298,692 shs$1.01 billion08/27/2025$17.06$17.14+0.47%$17.34$16.89329,482 shs$1.04 billion08/26/2025$16.58$17.06+2.90%$17.12$16.38514,487 shs$1.03 billion08/25/2025$17.38$16.58-4.60%$17.46$16.46331,318 shs$1.00 billion08/22/2025$16.78$17.38+3.58%$17.80$16.77805,613 shs$1.05 billion08/21/2025$16.35$16.78+2.63%$16.91$15.92688,310 shs$1.01 billion08/20/2025$16.11$16.35+1.49%$16.53$15.73601,792 shs$987.56 million08/19/2025$16.94$16.11-4.90%$16.82$15.91530,058 shs$973.04 million08/18/2025$16.95$16.94-0.06%$17.40$16.69394,017 shs$1.02 billion08/15/2025$16.86$16.95+0.53%$17.42$16.86536,949 shs$1.02 billion Get the Latest News and Ratings for SYRE and Related StocksEnter your email address below to receive the latest news and analysts' ratings for Spyre Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 08/14/2025$17.40$16.86-3.10%$17.25$16.77270,930 shs$1.02 billion08/13/2025$15.89$17.40+9.50%$17.42$15.82559,408 shs$1.05 billion08/12/2025$15.25$15.89+4.20%$15.93$15.31213,001 shs$959.76 million08/11/2025$15.16$15.25+0.59%$15.79$14.72291,989 shs$921.10 million08/08/2025$15.24$15.16-0.52%$15.29$14.75263,009 shs$913.85 million08/07/2025$15.96$15.24-4.51%$15.90$14.94417,085 shs$918.61 million08/06/2025$16.87$15.96-5.39%$16.88$15.66631,443 shs$962.07 million08/05/2025$16.16$16.87+4.39%$16.99$15.97363,483 shs$1.02 billion08/04/2025$16.26$16.16-0.62%$17.01$15.81728,922 shs$974.06 million08/01/2025$16.97$16.26-4.18%$17.04$16.23551,674 shs$980.09 million07/31/2025$17.29$16.97-1.85%$17.32$16.57599,802 shs$1.02 billion07/30/2025$16.77$17.29+3.10%$17.70$16.78884,505 shs$1.04 billion07/29/2025$16.98$16.77-1.24%$17.20$16.42472,722 shs$1.01 billion07/28/2025$17.79$16.98-4.55%$18.00$16.84641,898 shs$1.02 billion Related Companies PCVX Stock Chart PTCT Stock Chart LNTH Stock Chart ACLX Stock Chart AKRO Stock Chart ZLAB Stock Chart MIRM Stock Chart MLTX Stock Chart PTGX Stock Chart APLS Stock Chart Receive SYRE Stock News and Ratings via EmailSign-up to receive the latest news and ratings for Spyre Therapeutics and its competitors with MarketBeat's FREE daily newsletter. 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