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ProShares Ultra Nasdaq Biotechnology (the Fund) seeks investment results for a single day only, not for longer periods. The Fund seeks daily investment results, before fees and expenses, that correspond to twice (200%) the daily performance of the Index. The return of the Fund for a period longer than a single trading day will be the result of each day's returns compounded over the period, which will very likely differ from twice (200%) the return of the Nasdaq Biotechnology Index (the Index) for that period. The Fund does not seek to achieve its stated investment objective over a period of time greater than one day. The Fund invests in equity securities and derivatives that have similar daily performance characteristics as twice (200%) the daily return of the Index. The Fund invests in financial instruments whose value is derived from the value of an underlying asset, interest rate or index. ProShare Advisors LLC is the investment advisor of the Fund.

The JPMorgan Healthcare Leaders ETF Healthcare Leaders ETF (JDOC) is an exchange-traded fund that mostly invests in health care equity. The fund is actively managed, investing in equity securities issued by pharmaceutical, biotechnology, healthcare services, healthcare technology, medical technology and life sciences companies located around the globe.The adviser seeks to provide long-term capital appreciation. JDOC was launched on Nov 1, 2023 and is issued by JPMorgan Chase.

The Horizon Kinetics Medical ETF (MEDX) is an exchange-traded fund that mostly invests in health care equity. The fund actively invests in global companies within the broad health care sector. Stock selection and weighting emphasizes those invested in cancer research and pharmaceutical developments. MEDX was launched on Jan 27, 2023 and is managed by Horizon Kinetics.