Udit Batra
President and Chief Executive Officer at Waters
I would like to start the call on Slide three by paying our respects to the founder of our company, Jim Waters, who passed away on May 17. Jim was a brilliant and spirited scientist and a pioneer in liquid chromatography. I met Jim the first time in 2019 when he came to talk to me about the merits of a technology we had acquired in a previous company. We spent hours in front of a whiteboard debating how to manage innovation and, in particular, how the application of certain technology could deliver benefit. Jim continued reaching out to me, not just on technology, but also on our mutual love for science education and then, more recently, on Waters. Jim's legacy will live on with each and every one of our innovations as we continue to strive to deliver benefits. Our teams around the globe have continued to manage admirably through the pandemic, which is still very much with us. Most of all, we've kept the working environment safe for our employees and have remained flexible and resourceful as we continue to support our customers. I remain grateful for the ongoing resilience, commitment and dedication that our team has shown. Moving on to Slide 4. During today's call, I will provide a brief overview of our second quarter operating results as well as some commentary on our end markets, geographies and technologies. I will also update you on the progress of our transformation plan.
We continue to be focused on three primary objectives: number one, regaining our commercial momentum; number two, further strengthening our organization; and number three, building on a core -- on a strong core to access even higher growth areas. Amol will then review our financial results in detail and provide comments on our updated third quarter and full year financial outlook. We will then open up the phone lines to take your questions. As outlined on Slide 5, in the second quarter, our revenue grew 31% as reported and 27% on a constant currency basis, reflecting continued strength in our pharma and industrial end markets with strong demand for both our instrument systems and recurring revenue products across our major geographies. Sales for this quarter represent a 6% compounded average yearly growth versus our 2019 results on a constant currency basis. This translates to a 7% stacked CAGR versus 2019 for the first half of the year, again, on a constant currency basis. Our strong top line growth resulted in year-over-year Q2 non-GAAP adjusted earnings per share growth of 24% to $2.60 per share. Our top and bottom line performance translated into solid free cash flow performance and allowed us to strengthen our balance sheet. Looking more closely at our top line results in the quarter on Slide 6. First, by operating segment, our Waters Division grew 27%, while TA grew by 32% on a constant currency basis.
By end market, our largest market category, pharma, grew 31% in constant currency; industrial grew 28%; and academia and government grew 7%. Continued strength in sales to pharma customers was broad-based across customer segments, geographies and applications. Late-stage drug development activity drove sales of our tandem quad MS instrument systems such as the Xevo TQ-XS and Xevo TQ-S micro. Small molecule applications in manufacturing QA and QC grew across Asia, Europe and North America and were particularly strong in India. Industrial end market growth was also broad-based across geographies and applications, continuing its recovery so far this year. Food testing and environmental demand grew nicely in the quarter, as did our thermal and geometric portfolios. Turning to academic and government, which is less than 10% of our business, growth in the U.S. and Europe was partially offset by lumpiness in China. Year-to-date, our primary geographies have all returned to growth versus last year. Moving now to our sales performance by geography on a constant currency basis. Sales in Asia grew 28%, with China up almost 40% and India up almost 60%. Sales in the Americas grew 28% with the U.S. growing 26%, and sales in Europe grew 25%.
In the U.S., all end markets had strong year-over-year performance led by pharma and industrial. Academic and government saw a return to growth for the quarter as the market continues to recover. Europe's growth was also broad-based across end markets and subregions. Overall, pharma drove growth with strong demand in small molecule and large molecule applications. Industrial and academic and government markets continued their recovery, with both having strong quarters and strong starts to the first half of the year. China sales were up sharply in our pharma business, and we had solid growth in our industrial and applied end markets there as well. We're encouraged by our continued strength in the contract labs business due to strong execution of our growth initiatives. In India, sales for the quarter were again very strong even as the country continued to feel the effects from the pandemic. We're really grateful for the hard work and dedication of our colleagues who persevered through these challenging and tragic conditions.
Trends in Q2 and year-to-date for our LC instrument portfolio is a positive indicator for sustainable growth in consumables and service plans. In the second quarter, LC instruments grew across all major geographies with more than 40% growth, driven by our instrument replacement initiatives and new products, especially Arc HPLC and a strong uptake of our Premier instruments, both Arc and ACQUITY lines. This week, I spent time with customers at our Immerse innovation lab in Cambridge discussing the separation and purification of mRNA and oligonucleotide molecules. While mRNA vaccines have developed at a record pace, we are far from solving key issues such as aggregation and selective binding of plasmids and mRNA molecules to various surfaces, something that our Premier technology addresses really well. Further strengthening our UPLC portfolio, the Arc system was launched earlier this year for customers who need ultimate sensitivity.
The Arc Premier delivered fivefold improvement in detector sensitivity and tenfold improvement in assay-to-assay precision, helping labs accelerate time to market. Mass spec sales grew in excess of 30%, driven by demand from pharma research and development and food and environmental applications. This included high-resolution systems used for research applications such as the Xevo QTof, tandem quad led by our Xevo TQ-XS and TQ-S micro systems and our SQD and QDa single quad detectors utilized in high-performance LC-MS applications. We introduced the Waters SELECT SERIES MRT, a high-resolution mass spectrometer that combines multi-reflecting time-of-flight MRT technology with both enhanced DESI and new MALDI imaging sources. The MRT provides scientists with a unique combination of speed, resolution and mass accuracy especially relevant for applications in proteomics. We have been in conversations with customers to see how we can collaborate using MRT to analyze libraries of samples to create a database of proteins and metabolites to further understand the impact of therapeutics on a variety of tissues. Sales of precision chemistry columns, sample prep kits and reagents grew 28%, driven by increased utilization by our pharma customers and improved industrial demand.
Demand for our Premier Columns continues to be strong. The low double-digit 2-year stack growth of chemistry columns revenue in Q2 when compared to our 2019 base underscores the rebound in customer activity, the strong position of our portfolio and building momentum of our e-commerce initiative. Service also showed strong double-digit growth. Our service engineers continue to have good and improved access to our customer sites, and I'm grateful for the way they have served customers while continuing to navigate the challenges of the pandemic. Finally, with respect to TA, demand continues to rebound and was balanced across all major geographies and product lines, with particular strength in the U.S. and Europe. Let me now give you some highlights on our progress with the implementation of our transformation plan on Slide 7. Starting with our first priority, regaining our commercial momentum. We continue to see progress in our instrument replacement initiative.
Our recently released Arc HPLC has played an important role in the LC replacement initiative. Its improved mechanical specs and ability to seamlessly transfer networks from Alliance HPLC or other HPLC platforms have been very well received by our customers. We are already crossing a mid-single-digit stack growth versus 2019 on a year-to-date basis in LC. With our CRO and CDMO customers, our ability to develop and provide method transfer support continues to be a strong driver of growth. This segment grew 60% on a year-to-date basis versus the comparable period in 2019. Early strength that we saw in China has now been replicated in Europe as well as in the U.S. Our e-commerce and recurring revenue attachment initiatives are also starting to boost the momentum observed in our year-to-date 2-year stacked CAGR for chemistry and service revenue. Moving on to our second priority on Slide 8. We have strengthened our organization with the addition of Wei Jiang to our Board of Directors. Wei currently serves as President of Bayer Pharmaceuticals for China and APAC.
His results-driven experience will further expand the perspective of the Board that directly aligns with what is the strategy to accelerate growth and innovation. I'm also pleased to welcome Dr. Daniel Rush to Waters as Senior Vice President of Strategy and Transformation. Dan joins us from Bristol Myers, where he was VP of Worldwide Commercialization Strategy and Innovation. Dan joins several of our other technically trained Executive Committee members with experience in orchestrating transformations and M&A in relevant customer segments like pharma and diagnostics. This brings me to our third priority of building our core to drive durable growth. As you will see on Slide 9, Waters already has a strong foundation in large and growing end markets with a leading position of science and innovation in a roughly $65 billion market, a high exposure to end markets that grow around mid-single digits with a deep rooted presence in regulated end markets like QA/QC, a large installed base of instruments with over 50% recurring revenues, a diversified geographic base with over -- almost 40% sales in Asia and industry-leading margins with a strong financial flexibility. So you'll agree with me that this is a solid base to build off.
Now I'm on Slide 10. We built a team of leaders who have a strong track record of execution. Both Jon Pratt and Jianqing Bennett, Heads of the Waters Division and the TA Division, respectively, are highly experienced commercial leaders and are now very focused on building capabilities to sustain our commercial momentum. What gives me most pleasure is that we have started to hit our stride with new product introductions across the portfolio, and these are contributing to our sales momentum already. The leadership that is focused on execution and innovation is preparing us well to further build our portfolio to access even faster-growing adjacencies. We're exploring and nurturing opportunities both organic and inorganic to increase our exposure to biologics, be it bioprocessing reagents or novel modalities. We're actively shaping the promise of LC-MS in diagnostics and proteomics discovery applications and advancing lab connectivity applications through our informatics portfolio.
High growth areas such as sustainable polymers and renewable energy are a focus of the TA division. In summary, we've had a strong start to the year with a broad base -- with broad-based contributions from our end markets, product portfolio and geographies to our revenue growth. In addition to the impressive growth versus our 2020 base of comparison, our business dynamics and customer demand look healthy on a 2-year run rate basis. Markets we serve are in a healthy state, and our geographic regions are rebounding solidly from pandemic lows. We remain focused on the continued progress and success of our short-term initiatives aimed at tactically strengthening our core business. We're confident in the opportunities ahead to bring LC-MS products, separations expertise and compliant data management experience into high-growth biopharma and diagnostic applications. I look forward to continuing to share more with you as we progress on these various fronts.
With that, I'd like to pass the call over to Amol for a deeper review of the second quarter financials and our outlook for the remainder of 2021. Amol?