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ProShares Ultra Nasdaq Biotechnology (the Fund) seeks daily investment results, before fees and expenses, that correspond to twice (200%) the daily performance of the Index. The return of the Fund for a period longer than a single trading day will be the result of each day's returns compounded over the period, which will very likely differ from the inverse of the return of the Dow Jones United States Basic Materials Index (the Index) for that period. The Fund does not seek to achieve its stated investment objective over a period of time greater than one day. The Fund invests in derivatives that have similar daily performance characteristics as the inverse of the daily return of the Index. The Fund invests in financial instruments whose value is derived from the value of an underlying asset, interest rate or index. ProShare Advisors LLC is the investment advisor of the Fund.

The Principal Healthcare Innovators ETF (BTEC) is an exchange-traded fund that mostly invests in health care equity. The fund is actively managed to hold equities of small- and mid-cap healthcare firms in the US. The fund uses a proprietary, quantitative model to construct the portfolio. BTEC was launched on Aug 19, 2016 and is managed by Principal.

PowerShares S&P SmallCap Health Care Portfolio (the Fund) seeks investment results that correspond generally to the price and yield performance of the index called the S&P SmallCap 600 Capped HealthCare Index (the Underlying Index). The Underlying Index consists of common stocks of the United States healthcare companies. These are companies that are principally engaged in the business of providing healthcare-related products and services, including biotechnology, pharmaceuticals, medical technology and supplies, and facilities. The Fund seeks to normally invest at least 90% of its total assets in common stocks that comprise the Underlying Index. The Fund seeks to invest 25% or more of the value of its total assets in securities of issuers in an industry or group of industries to the extent that the Underlying Index concentrates in an industry or group of industries. The Fund's investment adviser is Invesco PowerShares Capital Management LLC.

PowerShares Dynamic Healthcare Sector Portfolio (the Fund) seeks investment results that correspond generally to the price and yield of the Dynamic Healthcare Sector Intellidex Index (the Index). The Fund will normally invest at least 90% of its total assets in common stocks that comprise the Index. The Index thoroughly evaluates companies based on a variety of investment merit criteria, including fundamental growth, stock valuation, investments and risk factors. Securities shown to possess the greatest capital appreciation potential are selected by the Index.The Fund invests only in health care sector. The Fund's investment advisor is PowerShares Capital Management LLC.