Vertex Pharmaceuticals (VRTX) Competitors $383.12 -3.99 (-1.03%) Closing price 09/19/2025 04:00 PM EasternExtended Trading$386.60 +3.48 (+0.91%) As of 09/19/2025 07:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock VRTX vs. AMZN, AXSM, CRSP, EDIT, GOOG, ISRG, MRNA, ABBV, LLY, and PFEShould you be buying Vertex Pharmaceuticals stock or one of its competitors? The main competitors of Vertex Pharmaceuticals include Amazon.com (AMZN), Axsome Therapeutics (AXSM), CRISPR Therapeutics (CRSP), Editas Medicine (EDIT), Alphabet (GOOG), Intuitive Surgical (ISRG), Moderna (MRNA), AbbVie (ABBV), Eli Lilly and Company (LLY), and Pfizer (PFE). Vertex Pharmaceuticals vs. Its Competitors Amazon.com Axsome Therapeutics CRISPR Therapeutics Editas Medicine Alphabet Intuitive Surgical Moderna AbbVie Eli Lilly and Company Pfizer Amazon.com (NASDAQ:AMZN) and Vertex Pharmaceuticals (NASDAQ:VRTX) are related large-cap companies, but which is the better investment? We will contrast the two companies based on the strength of their analyst recommendations, valuation, media sentiment, profitability, risk, dividends, earnings and institutional ownership. Is AMZN or VRTX more profitable? Vertex Pharmaceuticals has a net margin of 31.86% compared to Amazon.com's net margin of 10.54%. Vertex Pharmaceuticals' return on equity of 23.91% beat Amazon.com's return on equity.Company Net Margins Return on Equity Return on Assets Amazon.com10.54% 23.84% 11.14% Vertex Pharmaceuticals 31.86%23.91%17.14% Which has more risk and volatility, AMZN or VRTX? Amazon.com has a beta of 1.3, suggesting that its stock price is 30% more volatile than the S&P 500. Comparatively, Vertex Pharmaceuticals has a beta of 0.44, suggesting that its stock price is 56% less volatile than the S&P 500. Do institutionals and insiders have more ownership in AMZN or VRTX? 72.2% of Amazon.com shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 9.7% of Amazon.com shares are owned by company insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth. Do analysts prefer AMZN or VRTX? Amazon.com presently has a consensus price target of $263.30, indicating a potential upside of 13.75%. Vertex Pharmaceuticals has a consensus price target of $496.05, indicating a potential upside of 29.48%. Given Vertex Pharmaceuticals' higher probable upside, analysts plainly believe Vertex Pharmaceuticals is more favorable than Amazon.com.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Amazon.com 0 Sell rating(s) 2 Hold rating(s) 46 Buy rating(s) 2 Strong Buy rating(s) 3.00Vertex Pharmaceuticals 0 Sell rating(s) 13 Hold rating(s) 14 Buy rating(s) 1 Strong Buy rating(s) 2.57 Which has stronger valuation & earnings, AMZN or VRTX? Amazon.com has higher revenue and earnings than Vertex Pharmaceuticals. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Amazon.com, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioAmazon.com$637.96B3.87$59.25B$6.5635.29Vertex Pharmaceuticals$11.02B8.91-$535.60M$13.9927.39 Does the media favor AMZN or VRTX? In the previous week, Amazon.com had 205 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 238 mentions for Amazon.com and 33 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.38 beat Amazon.com's score of 1.06 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Amazon.com 172 Very Positive mention(s) 26 Positive mention(s) 22 Neutral mention(s) 11 Negative mention(s) 5 Very Negative mention(s) Positive Vertex Pharmaceuticals 30 Very Positive mention(s) 0 Positive mention(s) 2 Neutral mention(s) 1 Negative mention(s) 0 Very Negative mention(s) Positive SummaryAmazon.com beats Vertex Pharmaceuticals on 9 of the 17 factors compared between the two stocks. Get Vertex Pharmaceuticals News Delivered to You Automatically Sign up to receive the latest news and ratings for VRTX and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding VRTX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart VRTX vs. The Competition Export to ExcelMetricVertex PharmaceuticalsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$99.25B$3.16B$5.79B$10.40BDividend YieldN/A2.37%5.63%4.60%P/E Ratio27.3920.5276.4826.75Price / Sales8.91446.54531.72124.23Price / CashN/A46.0037.9261.55Price / Book6.019.6613.726.40Net Income-$535.60M-$53.02M$3.29B$271.62M7 Day Performance-2.89%3.12%2.66%3.46%1 Month Performance-2.85%7.57%6.02%9.87%1 Year Performance-17.59%11.17%80.02%28.45% Vertex Pharmaceuticals Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)VRTXVertex Pharmaceuticals4.9058 of 5 stars$383.12-1.0%$496.05+29.5%-19.8%$99.25B$11.02B27.396,100Positive NewsHigh Trading VolumeAMZNAmazon.com4.794 of 5 stars$231.43+1.4%$262.87+13.6%+21.9%$2.47T$637.96B35.281,556,000Trending NewsAnalyst ForecastAXSMAxsome Therapeutics4.8935 of 5 stars$116.78-1.4%$177.86+52.3%+22.9%$5.83B$385.69M-23.03380Insider TradeAnalyst RevisionCRSPCRISPR Therapeutics2.9721 of 5 stars$57.84+2.8%$71.60+23.8%+25.9%$5.26B$37.31M-10.65460News CoverageAnalyst ForecastEDITEditas Medicine3.9609 of 5 stars$2.67-0.7%$5.10+91.0%-27.6%$240.09M$32.31M-0.94230GOOGAlphabet4.6674 of 5 stars$251.76+4.3%$227.56-9.6%+56.4%$3.04T$350.02B26.81190,200Trending NewsInsider TradeShort Interest ↓ISRGIntuitive Surgical4.9525 of 5 stars$433.99-3.5%$595.95+37.3%-10.5%$155.58B$8.35B60.5315,638Positive NewsAnalyst RevisionMRNAModerna4.4542 of 5 stars$23.88+1.6%$41.81+75.1%-62.9%$9.29B$3.24B-3.175,800ABBVAbbVie4.7632 of 5 stars$217.92-0.2%$218.76+0.4%+14.8%$384.97B$58.33B103.7755,000Trending NewsAnalyst ForecastAnalyst RevisionLLYEli Lilly and Company4.9971 of 5 stars$748.26-0.9%$941.35+25.8%-17.7%$708.20B$53.26B48.9147,000Trending NewsAnalyst ForecastPFEPfizer4.9832 of 5 stars$23.98+0.5%$28.12+17.3%-19.0%$136.34B$63.63B12.7681,000Positive NewsAnalyst Upgrade Related Companies and Tools Related Companies Amazon.com Alternatives Axsome Therapeutics Alternatives CRISPR Therapeutics Alternatives Editas Medicine Alternatives Alphabet Alternatives Intuitive Surgical Alternatives Moderna Alternatives AbbVie Alternatives Eli Lilly and Company Alternatives Pfizer Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:VRTX) was last updated on 9/20/2025 by MarketBeat.com Staff From Our PartnersForget NVDA. Put $1,000 into this stock nowA massive money shift is underway in the AI market. And it's opening up an extraordinary opportunity in a NEW ...Chaikin Analytics | SponsoredCrypto Gets Official Government Backing—Here's the WinnerTrump Just Signed the GENIUS Act—One Coin is About to Explode We're at the BEGINNING of smart money really ...Crypto 101 Media | SponsoredHe Called Nvidia at $1.10. Now, He Says THIS Stock Will…The original Magnificent Seven returned 16,894%—turning $7K into $1.18 million. Now, the man who called Nvi...The Oxford Club | SponsoredElon’s Out 🚫. Trump’s DOGE Payouts Keep Flowing (Up to $32K a Year)DOGE payouts are already moving. Every 90 days, billions flow out — whether you’ve claimed your share or not. ...Angel Publishing | SponsoredNvidia CEO Makes First Ever Tesla AnnouncementWhile headlines focus on Tesla’s car sales, tech analyst Jeff Brown says the real story is Tesla’s role in a $...Brownstone Research | SponsoredForget Tesla — This Tiny AI Stock Is Musk’s Real PlayWhile Wall Street focused on Tesla’s earnings, Elon Musk was quietly building a supercomputer so powerful it c...Behind the Markets | SponsoredAn $8 trillion-dollar discovery 17,000 ft underwater A strange rock pulled from the ocean floor may hold the key to a $16 trillion resource boom. Inside it: materi...Porter & Company | SponsoredWhy silver could go 100X higherInflation is destroying purchasing power at 10–14% per year. Gold will protect you — but not the way you think...Golden Portfolio | Sponsored Adding Choose a watchlist: Watchlist Adding You have already added ten stocks to your watchlist. Upgrade to MarketBeat All Access to add more stocks to your watchlist. Adding Vertex Pharmaceuticals Incorporated Please log in to your account or sign up in order to add this asset to your watchlist. Share Vertex Pharmaceuticals With A Colleague Link copied to clipboard. Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. Real-time analyst ratings, insider transactions, earnings data, and more. Our daily ratings and market update email newsletter. Sign in to your free account to enjoy all that MarketBeat has to offer. Sign In Create Account Your Email Address: Email Address Required Your Password: Password Required Log In or Sign in with Facebook Sign in with Google Forgot your password? Your Email Address: Please enter your email address. Please enter a valid email address Choose a Password: Please enter your password. Your password must be at least 8 characters long and contain at least 1 number, 1 letter, and 1 special character. Create My Account (Free) or Sign in with Facebook Sign in with Google By creating a free account, you agree to our terms of service. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Free VRTX Stock Alerts