Vertex Pharmaceuticals (VRTX) Competitors $396.62 -4.38 (-1.09%) Closing price 09/3/2025 04:00 PM EasternExtended Trading$396.83 +0.21 (+0.05%) As of 09/3/2025 07:57 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock VRTX vs. AMZN, AXSM, CRSP, EDIT, GOOG, ISRG, MRNA, ABBV, LLY, and PFEShould you be buying Vertex Pharmaceuticals stock or one of its competitors? The main competitors of Vertex Pharmaceuticals include Amazon.com (AMZN), Axsome Therapeutics (AXSM), CRISPR Therapeutics (CRSP), Editas Medicine (EDIT), Alphabet (GOOG), Intuitive Surgical (ISRG), Moderna (MRNA), AbbVie (ABBV), Eli Lilly and Company (LLY), and Pfizer (PFE). Vertex Pharmaceuticals vs. Its Competitors Amazon.com Axsome Therapeutics CRISPR Therapeutics Editas Medicine Alphabet Intuitive Surgical Moderna AbbVie Eli Lilly and Company Pfizer Vertex Pharmaceuticals (NASDAQ:VRTX) and Amazon.com (NASDAQ:AMZN) are related large-cap companies, but which is the better stock? We will compare the two businesses based on the strength of their profitability, media sentiment, earnings, analyst recommendations, valuation, risk, dividends and institutional ownership. Is VRTX or AMZN more profitable? Vertex Pharmaceuticals has a net margin of 31.86% compared to Amazon.com's net margin of 10.54%. Vertex Pharmaceuticals' return on equity of 23.91% beat Amazon.com's return on equity.Company Net Margins Return on Equity Return on Assets Vertex Pharmaceuticals31.86% 23.91% 17.14% Amazon.com 10.54%23.84%11.14% Which has more volatility & risk, VRTX or AMZN? Vertex Pharmaceuticals has a beta of 0.44, meaning that its stock price is 56% less volatile than the S&P 500. Comparatively, Amazon.com has a beta of 1.3, meaning that its stock price is 30% more volatile than the S&P 500. Do institutionals & insiders have more ownership in VRTX or AMZN? 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. Comparatively, 72.2% of Amazon.com shares are owned by institutional investors. 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Comparatively, 10.8% of Amazon.com shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term. Which has preferable earnings and valuation, VRTX or AMZN? Amazon.com has higher revenue and earnings than Vertex Pharmaceuticals. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Amazon.com, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioVertex Pharmaceuticals$11.02B9.23-$535.60M$13.9928.35Amazon.com$637.96B3.78$59.25B$6.5634.45 Do analysts recommend VRTX or AMZN? Vertex Pharmaceuticals currently has a consensus target price of $497.10, indicating a potential upside of 25.33%. Amazon.com has a consensus target price of $262.87, indicating a potential upside of 16.32%. Given Vertex Pharmaceuticals' higher possible upside, equities analysts clearly believe Vertex Pharmaceuticals is more favorable than Amazon.com.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Vertex Pharmaceuticals 0 Sell rating(s) 13 Hold rating(s) 13 Buy rating(s) 1 Strong Buy rating(s) 2.56Amazon.com 0 Sell rating(s) 2 Hold rating(s) 46 Buy rating(s) 2 Strong Buy rating(s) 3.00 Does the media prefer VRTX or AMZN? In the previous week, Amazon.com had 206 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 239 mentions for Amazon.com and 33 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.46 beat Amazon.com's score of 1.06 indicating that Vertex Pharmaceuticals is being referred to more favorably in the media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Vertex Pharmaceuticals 30 Very Positive mention(s) 1 Positive mention(s) 2 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Amazon.com 177 Very Positive mention(s) 17 Positive mention(s) 23 Neutral mention(s) 18 Negative mention(s) 4 Very Negative mention(s) Positive SummaryAmazon.com beats Vertex Pharmaceuticals on 9 of the 17 factors compared between the two stocks. Get Vertex Pharmaceuticals News Delivered to You Automatically Sign up to receive the latest news and ratings for VRTX and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding VRTX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart VRTX vs. The Competition Export to ExcelMetricVertex PharmaceuticalsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$100.25B$3.11B$5.77B$9.76BDividend YieldN/A2.28%6.66%4.49%P/E Ratio28.3521.1082.3726.60Price / Sales9.23371.03525.77170.66Price / CashN/A43.5325.7028.92Price / Book5.928.1310.646.56Net Income-$535.60M-$53.35M$3.28B$266.04M7 Day Performance1.17%0.73%0.09%-0.89%1 Month Performance-16.02%7.76%8.90%4.34%1 Year Performance-17.12%11.97%48.37%24.06% Vertex Pharmaceuticals Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)VRTXVertex Pharmaceuticals4.982 of 5 stars$396.62-1.1%$497.10+25.3%-16.6%$100.25B$11.02B28.356,100Positive NewsAnalyst ForecastAMZNAmazon.com4.7886 of 5 stars$227.94-0.4%$262.87+15.3%+28.2%$2.43T$637.96B34.751,556,000Trending NewsAXSMAxsome Therapeutics4.7627 of 5 stars$116.31-1.9%$178.00+53.0%+36.1%$5.80B$495.03M-22.94380Positive NewsAnalyst ForecastInsider TradeCRSPCRISPR Therapeutics3.5926 of 5 stars$54.13-0.3%$71.60+32.3%+16.4%$4.92B$35M-9.97460Analyst RevisionEDITEditas Medicine4.0267 of 5 stars$2.72-2.9%$5.10+87.5%-28.4%$244.58M$38.90M-0.95230News CoverageAnalyst ForecastGap UpGOOGAlphabet4.5612 of 5 stars$209.16+1.2%$215.19+2.9%+45.7%$2.53T$371.40B22.27190,200Trending NewsAnalyst ForecastGap UpISRGIntuitive Surgical4.9567 of 5 stars$468.44-1.6%$595.95+27.2%-8.7%$167.93B$8.35B65.3315,638Positive NewsInsider TradeMRNAModerna4.5519 of 5 stars$25.35-6.5%$42.88+69.2%-67.0%$9.86B$3.24B-3.375,800ABBVAbbVie4.6298 of 5 stars$207.58-1.4%$214.95+3.6%+7.1%$366.70B$58.33B98.8555,000Trending NewsLLYEli Lilly and Company5 of 5 stars$696.08-2.2%$950.17+36.5%-23.0%$658.81B$45.04B45.5047,000Trending NewsAnalyst RevisionPFEPfizer4.8441 of 5 stars$25.15-2.8%$28.12+11.8%-12.5%$142.99B$63.63B13.3881,000Trending News Related Companies and Tools Related Companies Amazon.com Alternatives Axsome Therapeutics Alternatives CRISPR Therapeutics Alternatives Editas Medicine Alternatives Alphabet Alternatives Intuitive Surgical Alternatives Moderna Alternatives AbbVie Alternatives Eli Lilly and Company Alternatives Pfizer Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:VRTX) was last updated on 9/4/2025 by MarketBeat.com Staff From Our PartnersCrypto Income (almost instantly)How would you like to collect a small percentage of the $4 billion changing hands daily in the crypto market? ...Awesomely, LLC | SponsoredRetire Comfortably with These New Monthly Income ETFs?Too many retirees lie awake at night, worried their savings won’t last. 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