Vertex Pharmaceuticals (VRTX) Competitors $407.90 -6.97 (-1.68%) Closing price 03:59 PM EasternExtended Trading$407.78 -0.12 (-0.03%) As of 04:15 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock VRTX vs. AMZN, AXSM, CRSP, GOOG, ISRG, MRNA, RGEN, ABBV, LLY, and PFEShould you be buying Vertex Pharmaceuticals stock or one of its competitors? The main competitors of Vertex Pharmaceuticals include Amazon.com (AMZN), Axsome Therapeutics (AXSM), CRISPR Therapeutics (CRSP), Alphabet (GOOG), Intuitive Surgical (ISRG), Moderna (MRNA), Repligen (RGEN), AbbVie (ABBV), Eli Lilly and Company (LLY), and Pfizer (PFE). Vertex Pharmaceuticals vs. Its Competitors Amazon.com Axsome Therapeutics CRISPR Therapeutics Alphabet Intuitive Surgical Moderna Repligen AbbVie Eli Lilly and Company Pfizer Amazon.com (NASDAQ:AMZN) and Vertex Pharmaceuticals (NASDAQ:VRTX) are related large-cap companies, but which is the better business? We will contrast the two businesses based on the strength of their profitability, earnings, risk, dividends, analyst recommendations, media sentiment, institutional ownership and valuation. Is AMZN or VRTX more profitable? Vertex Pharmaceuticals has a net margin of 31.86% compared to Amazon.com's net margin of 10.54%. Vertex Pharmaceuticals' return on equity of 23.91% beat Amazon.com's return on equity.Company Net Margins Return on Equity Return on Assets Amazon.com10.54% 23.84% 11.14% Vertex Pharmaceuticals 31.86%23.91%17.14% Which has better earnings and valuation, AMZN or VRTX? Amazon.com has higher revenue and earnings than Vertex Pharmaceuticals. Vertex Pharmaceuticals is trading at a lower price-to-earnings ratio than Amazon.com, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioAmazon.com$637.96B3.62$59.25B$6.5632.97Vertex Pharmaceuticals$11.42B9.16-$535.60M$13.9929.16 Do analysts prefer AMZN or VRTX? Amazon.com presently has a consensus target price of $266.26, indicating a potential upside of 23.11%. Vertex Pharmaceuticals has a consensus target price of $494.38, indicating a potential upside of 21.20%. Given Amazon.com's stronger consensus rating and higher probable upside, equities research analysts clearly believe Amazon.com is more favorable than Vertex Pharmaceuticals.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Amazon.com 0 Sell rating(s) 1 Hold rating(s) 47 Buy rating(s) 3 Strong Buy rating(s) 3.04Vertex Pharmaceuticals 0 Sell rating(s) 12 Hold rating(s) 16 Buy rating(s) 1 Strong Buy rating(s) 2.62 Do institutionals and insiders believe in AMZN or VRTX? 72.2% of Amazon.com shares are held by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are held by institutional investors. 9.7% of Amazon.com shares are held by insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term. Does the media prefer AMZN or VRTX? In the previous week, Amazon.com had 202 more articles in the media than Vertex Pharmaceuticals. MarketBeat recorded 234 mentions for Amazon.com and 32 mentions for Vertex Pharmaceuticals. Vertex Pharmaceuticals' average media sentiment score of 1.19 beat Amazon.com's score of 0.96 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Amazon.com 147 Very Positive mention(s) 35 Positive mention(s) 30 Neutral mention(s) 13 Negative mention(s) 5 Very Negative mention(s) Positive Vertex Pharmaceuticals 21 Very Positive mention(s) 2 Positive mention(s) 6 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Which has more risk & volatility, AMZN or VRTX? Amazon.com has a beta of 1.28, suggesting that its share price is 28% more volatile than the S&P 500. Comparatively, Vertex Pharmaceuticals has a beta of 0.43, suggesting that its share price is 57% less volatile than the S&P 500. SummaryAmazon.com beats Vertex Pharmaceuticals on 10 of the 17 factors compared between the two stocks. Get Vertex Pharmaceuticals News Delivered to You Automatically Sign up to receive the latest news and ratings for VRTX and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding VRTX and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart VRTX vs. The Competition Export to ExcelMetricVertex PharmaceuticalsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$104.58B$3.32B$6.02B$10.26BDividend YieldN/A2.29%5.66%4.69%P/E Ratio29.1622.1485.3626.60Price / Sales9.16417.33583.50178.23Price / CashN/A47.1938.3262.20Price / Book6.4010.2312.736.54Net Income-$535.60M-$52.40M$3.30B$275.87M7 Day Performance1.14%0.94%1.04%-1.32%1 Month Performance4.98%12.42%7.62%5.24%1 Year Performance-14.33%30.20%79.71%31.56% Vertex Pharmaceuticals Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)VRTXVertex Pharmaceuticals4.8159 of 5 stars$407.90-1.7%$494.38+21.2%-11.3%$104.58B$11.42B29.166,100Positive NewsAnalyst ForecastAMZNAmazon.com4.7988 of 5 stars$222.17+1.1%$264.13+18.9%+23.0%$2.37T$637.96B33.871,556,000Trending NewsAnalyst ForecastOptions VolumeAXSMAxsome Therapeutics4.713 of 5 stars$117.62+0.7%$177.86+51.2%+46.7%$5.87B$385.69M-23.20380Trending NewsAnalyst ForecastInsider TradeAnalyst RevisionCRSPCRISPR Therapeutics1.5288 of 5 stars$63.77+3.4%$71.50+12.1%+65.0%$5.80B$37.31M-11.74460News CoverageAnalyst ForecastGOOGAlphabet4.5013 of 5 stars$244.36-1.1%$230.35-5.7%+48.5%$2.96T$350.02B26.02190,200Trending NewsAnalyst UpgradeISRGIntuitive Surgical4.9397 of 5 stars$439.22-0.4%$595.95+35.7%-9.5%$157.45B$8.35B61.2615,638Positive NewsAnalyst ForecastMRNAModerna4.291 of 5 stars$25.33+3.4%$41.81+65.1%-53.2%$9.86B$3.24B-3.365,800Analyst ForecastRGENRepligen4.602 of 5 stars$124.09-1.2%$168.75+36.0%+9.0%$6.98B$634.44M-496.341,778Analyst ForecastABBVAbbVie4.5977 of 5 stars$222.93+1.1%$223.45+0.2%+18.7%$393.82B$56.33B106.1655,000Positive NewsAnalyst ForecastLLYEli Lilly and Company4.9928 of 5 stars$725.54+0.1%$939.61+29.5%-7.1%$686.69B$45.04B47.4247,000Trending NewsAnalyst ForecastPFEPfizer4.9619 of 5 stars$23.84+0.3%$28.12+17.9%-16.5%$135.54B$63.63B12.6881,000Trending NewsDividend AnnouncementAnalyst ForecastOptions Volume Related Companies and Tools Related Companies Amazon.com Alternatives Axsome Therapeutics Alternatives CRISPR Therapeutics Alternatives Alphabet Alternatives Intuitive Surgical Alternatives Moderna Alternatives Repligen Alternatives AbbVie Alternatives Eli Lilly and Company Alternatives Pfizer Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:VRTX) was last updated on 10/10/2025 by MarketBeat.com Staff From Our PartnersBitcoin grabs headlines, but smart money likes this tokenIf you're a futures trader (or want to be one), this could be the biggest shift you'll ever see in the prop fi...Neuro Street Trading Academy | SponsoredYour Bank Account Is No Longer SafeWhat If Washington Declared That: YOUR Money ISN'T Actually Yours? 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