Compare Stocks: ARVN, SION, AMLX, and HRMY

Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
AMLX Amylyx Pharmaceuticals	$19.92 -1.9%	$16.55	$7.48 ▼ $20.94	$2.22B	-0.21	1.37 million shs	127,731 shs
ARVN Arvinas	$7.98 -0.6%	$8.09	$6.05 ▼ $14.51	$514.17M	1.74	813,441 shs	22,578 shs
HRMY Harmony Biosciences	$35.03 -0.6%	$34.48	$25.52 ▼ $40.87	$2.03B	0.94	848,093 shs	37,295 shs
SION Sionna Therapeutics	$46.10 -2.2%	$41.66	$16.48 ▼ $51.56	$2.08B	1.33	389,539 shs	42,900 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
AMLX Amylyx Pharmaceuticals	0.00%	+10.32%	+11.17%	+26.86%	+163.08%
ARVN Arvinas	0.00%	0.00%	-4.29%	-23.60%	+8.22%
HRMY Harmony Biosciences	0.00%	-0.23%	-5.42%	+10.71%	+2.44%
SION Sionna Therapeutics	0.00%	+3.13%	+7.14%	+20.38%	+178.55%

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
AMLX Amylyx Pharmaceuticals	$19.92 -1.9%	$16.55	$7.48 ▼ $20.94	$2.22B	-0.21	1.37 million shs	127,731 shs
ARVN Arvinas	$7.98 -0.6%	$8.09	$6.05 ▼ $14.51	$514.17M	1.74	813,441 shs	22,578 shs
HRMY Harmony Biosciences	$35.03 -0.6%	$34.48	$25.52 ▼ $40.87	$2.03B	0.94	848,093 shs	37,295 shs
SION Sionna Therapeutics	$46.10 -2.2%	$41.66	$16.48 ▼ $51.56	$2.08B	1.33	389,539 shs	42,900 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
AMLX Amylyx Pharmaceuticals	0.00%	+10.32%	+11.17%	+26.86%	+163.08%
ARVN Arvinas	0.00%	0.00%	-4.29%	-23.60%	+8.22%
HRMY Harmony Biosciences	0.00%	-0.23%	-5.42%	+10.71%	+2.44%
SION Sionna Therapeutics	0.00%	+3.13%	+7.14%	+20.38%	+178.55%

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
AMLX Amylyx Pharmaceuticals	2.90	Moderate Buy	$24.63	23.64% Upside
ARVN Arvinas	2.46	Hold	$15.42	93.19% Upside
HRMY Harmony Biosciences	2.50	Moderate Buy	$42.63	21.68% Upside
SION Sionna Therapeutics	2.85	Moderate Buy	$53.22	15.45% Upside

Current Analyst Ratings Breakdown

Latest ARVN, SION, AMLX, and HRMY Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
7/31/2026	HRMY Harmony Biosciences	Mizuho Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Outperform	$50.00 ➝ $51.00
7/30/2026	ARVN Arvinas	Weiss Ratings Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Downgrade	Sell (D-) ➝ Sell (E+)
7/20/2026	AMLX Amylyx Pharmaceuticals	Mizuho Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Outperform	$21.00 ➝ $24.00
7/16/2026	HRMY Harmony Biosciences	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy	$55.00
7/13/2026	ARVN Arvinas	Weiss Ratings Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Sell (E+) ➝ Sell (D-)
7/13/2026	HRMY Harmony Biosciences	Zacks Research Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Hold ➝ Strong-Buy
6/30/2026	HRMY Harmony Biosciences	Deutsche Bank Aktiengesellschaft Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Hold	$30.00 ➝ $36.00
6/25/2026	ARVN Arvinas	Weiss Ratings Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Downgrade	Sell (D-) ➝ Sell (E+)
6/25/2026	AMLX Amylyx Pharmaceuticals	Guggenheim Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Buy	$30.00 ➝ $40.00
6/24/2026	HRMY Harmony Biosciences	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy
6/23/2026	HRMY Harmony Biosciences	Weiss Ratings Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Hold (C-) ➝ Hold (C)

(Data available from 8/3/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
AMLX Amylyx Pharmaceuticals	$87.37M	25.35	N/A	N/A	$2.78 per share	7.16
ARVN Arvinas	$89.40M	5.76	N/A	N/A	$6.76 per share	1.18
HRMY Harmony Biosciences	$899.11M	2.26	$3.16 per share	11.08	$15.11 per share	2.32
SION Sionna Therapeutics	N/A	N/A	N/A	N/A	$6.88 per share	N/A

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
AMLX Amylyx Pharmaceuticals	-$144.74M	-$1.50	N/A	N/A	N/A	N/A	-55.69%	-50.73%	8/6/2026 (Estimated)
ARVN Arvinas	-$80.80M	-$3.32	N/A	N/A	N/A	-247.54%	-44.38%	-28.38%	8/4/2026 (Estimated)
HRMY Harmony Biosciences	$158.69M	$2.48	14.14	9.05	0.33	16.20%	17.19%	11.99%	8/4/2026 (Estimated)
SION Sionna Therapeutics	-$75.27M	-$1.93	N/A	N/A	N/A	N/A	-27.31%	-25.88%	N/A

Latest ARVN, SION, AMLX, and HRMY Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/6/2026	Q2 2026	AMLX Amylyx Pharmaceuticals	-$0.3609	N/A	N/A	N/A	N/A	N/A
8/4/2026	Q2 2026	ARVN Arvinas	-$0.24	N/A	N/A	N/A	$60.71 million	N/A
8/4/2026	Q2 2026	HRMY Harmony Biosciences	$0.9560	N/A	N/A	N/A	$250.77 million	N/A
5/12/2026	Q1 2026	SION Sionna Therapeutics	-$0.52	-$0.60	-$0.08	-$0.60	N/A	N/A
5/11/2026	Q1 2026	ARVN Arvinas	-$0.95	-$0.90	+$0.05	-$0.90	$16.61 million	$15.60 million
5/7/2026	Q1 2026	AMLX Amylyx Pharmaceuticals	-$0.34	-$0.37	-$0.03	-$0.37	N/A	N/A
5/7/2026	Q1 2026	HRMY Harmony Biosciences	$0.76	$0.55	-$0.21	$0.55	$220.84 million	$215.39 million

Compare Dividends

Company	Annual Payout	Dividend Yield	5-Year Annualized Dividend Growth	Payout Ratio	Years of Consecutive Growth
AMLX Amylyx Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
ARVN Arvinas	N/A	N/A	N/A	N/A	N/A
HRMY Harmony Biosciences	N/A	N/A	N/A	N/A	N/A
SION Sionna Therapeutics	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
AMLX Amylyx Pharmaceuticals	N/A	17.85	17.85
ARVN Arvinas	N/A	5.44	5.44
HRMY Harmony Biosciences	0.15	3.58	3.56
SION Sionna Therapeutics	N/A	22.60	22.60

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
AMLX Amylyx Pharmaceuticals	95.84%
ARVN Arvinas	95.19%
HRMY Harmony Biosciences	86.23%
SION Sionna Therapeutics	N/A

Insider Ownership

Company	Insider Ownership
AMLX Amylyx Pharmaceuticals	10.90%
ARVN Arvinas	7.30%
HRMY Harmony Biosciences	11.00%
SION Sionna Therapeutics	5.10%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
AMLX Amylyx Pharmaceuticals	200	111.19 million	99.07 million	Optionable
ARVN Arvinas	420	64.52 million	59.81 million	Optionable
HRMY Harmony Biosciences	200	57.89 million	51.53 million	Optionable
SION Sionna Therapeutics	35	45.15 million	42.85 million	N/A

ARVN, SION, AMLX, and HRMY Headlines

Recent News About These Companies

Perceptive Advisors LLC Decreases Position in Sionna Therapeutics, Inc. $SION

August 2 at 6:07 AM | marketbeat.com

36,540 Shares in Sionna Therapeutics, Inc. $SION Purchased by Stempoint Capital LP

July 30, 2026 | marketbeat.com

Brokerages Set Sionna Therapeutics, Inc. (NASDAQ:SION) Target Price at $53.22

July 30, 2026 | americanbankingnews.com

Sionna Therapeutics, Inc. $SION Position Decreased by Orbimed Advisors LLC

July 27, 2026 | marketbeat.com

Sionna Therapeutics, Inc. (NASDAQ:SION) Given Consensus Recommendation of "Moderate Buy" by Analysts

July 25, 2026 | marketbeat.com

Sionna Therapeutics (NASDAQ:SION) Stock Price Down 4.5% - What's Next?

July 20, 2026 | marketbeat.com

Jennison Associates LLC Has $58.18 Million Holdings in Sionna Therapeutics, Inc. $SION

July 20, 2026 | marketbeat.com

Sionna Therapeutics (NASDAQ:SION) Hits New 12-Month High - Should You Buy?

July 18, 2026 | marketbeat.com

Sionna Therapeutics (NASDAQ:SION) Trading Up 5.3% - Time to Buy?

July 17, 2026 | marketbeat.com

Sionna Therapeutics

July 13, 2026 | fool.com

Candriam S.C.A. Buys New Position in Sionna Therapeutics, Inc. $SION

July 13, 2026 | marketbeat.com

Insider Selling: Sionna Therapeutics (NASDAQ:SION) Director Sells 85,918 Shares

July 10, 2026 | insidertrades.com

Insider Selling: Sionna Therapeutics (NASDAQ:SION) Director Sells $3,854,281.48 in Stock

July 9, 2026 | marketbeat.com

Sionna Therapeutics (NASDAQ:SION) Director Sells 115,844 Shares

July 3, 2026 | insidertrades.com

Sionna Therapeutics: NBD1 Stabilization Could Redefine Cystic Fibrosis Treatment

June 30, 2026 | seekingalpha.com

Sionna Therapeutics, Inc. Common Stock (SION) Institutional Holdings

June 23, 2026 | nasdaq.com

Sionna Stockholders Reelect Directors, Ratify Deloitte as Auditor

June 18, 2026 | tipranks.com

Sionna Therapeutics, Inc. (SION) Presents at Goldman Sachs 47th Annual Global Healthcare Conference 2026 Transcript

June 10, 2026 | seekingalpha.com

Sionna Therapeutics to Participate in Upcoming June 2026 Investor Conferences

May 27, 2026 | globenewswire.com

Stifel Nicolaus Sticks to Their Buy Rating for Sionna Therapeutics, Inc. (SION)

May 26, 2026 | theglobeandmail.com

Freedom Broker downgrades Sionna Therapeutics (SION)

May 21, 2026 | msn.com

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ARVN, SION, AMLX, and HRMY Company Descriptions

Amylyx Pharmaceuticals NASDAQ:AMLX

$19.92 -0.39 (-1.94%)

As of 10:07 AM Eastern

Amylyx Pharmaceuticals, Inc., a commercial-stage biotechnology company, engages in the discovery and development of treatment for amyotrophic lateral sclerosis (ALS) and neurodegenerative diseases. The company's products include RELYVRIO, a dual UPR-Bax apoptosis inhibitor composed of sodium phenylbutyrate and taurursodiol for the treatment of ALS in adults in the United States and marketed as ALBRIOZA for the treatment of ALS in Canada. It is also developing AMX0114 for other neurodegenerative diseases. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.

Arvinas NASDAQ:ARVN

$7.98 -0.05 (-0.62%)

As of 10:07 AM Eastern

Arvinas, Inc., a clinical-stage biotechnology company, engages in the discovery, development, and commercialization of therapies to degrade disease-causing proteins. The company engineers proteolysis targeting chimeras (PROTAC) targeted protein degraders that are designed to harness the body's own natural protein disposal system to degrade and remove disease-causing proteins. Its product pipeline includes Bavdegalutamide and ARV-766, investigational orally bioavailable PROTAC protein degraders for the treatment of men with metastatic castration-resistant prostate cancer, which are in Phase 1/2 clinical trials; and ARV-471, an orally bioavailable estrogen receptor degrading PROTAC targeted protein degrader for the treatment of patients with locally advanced or metastatic estrogen receptor+/human epidermal growth factor receptor 2-breast cancer, which is Phase 3 clinical trial. Arvinas, Inc. has collaborations with Pfizer Inc., Genentech, Inc., F. Hoffman-La Roche Ltd., Carrick Therapeutics Limited, and Bayer AG. The company was founded in 2013 and is based in New Haven, Connecticut.

Harmony Biosciences NASDAQ:HRMY

$35.03 -0.21 (-0.60%)

As of 10:07 AM Eastern

Harmony Biosciences Holdings, Inc., a commercial-stage pharmaceutical company, focuses on developing and commercializing therapies for patients with rare and other neurological diseases in the United States. The company offers WAKIX (pitolisant), a molecule with a novel mechanism of action for the treatment of excessive daytime sleepiness in adult patients with narcolepsy. It also offers HBS-102, a melanin-concentrating hormone receptor 1 for MCH neurons. The company was formerly known as Harmony Biosciences II, Inc. and changed its name to Harmony Biosciences Holdings, Inc. in February 2020. Harmony Biosciences Holdings, Inc. was incorporated in 2017 and is headquartered in Plymouth Meeting, Pennsylvania.

Sionna Therapeutics NASDAQ:SION

$46.10 -1.03 (-2.19%)

As of 10:07 AM Eastern

We are a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (“CF”) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (“CFTR”) protein to deliver clinically meaningful benefit to CF patients. Our goal is to deliver differentiated medicines for people living with CF that can restore their CFTR function to as close to normal as possible by directly stabilizing CFTR’s nucleotide-binding domain 1 (“NBD1”). Despite having long been identified as a critical component for proper CFTR function, NBD1 has been considered “undruggable,” and none of the currently approved CF therapies directly stabilizes NBD1. Worldwide revenue for approved CFTR modulators was approximately $10 billion in 2023 and is expected to grow to $15 billion by 2029. Leveraging more than a decade of our co-founders’ research on NBD1, we are advancing a pipeline of small molecules engineered to correct the defects caused by the F508del genetic mutation, which resides in the NBD1 domain. Approximately 90% of people with CF carry at least one copy of the F508del genetic mutation. We believe stabilizing NBD1 is central to unlocking dramatic improvements in clinical outcomes and quality of life for CF patients. We have employed biophysical, cell-based and virtual screening campaigns and extensive use of structural biology to guide the optimization of novel small molecule NBD1 stabilizers. We are conducting ongoing Phase 1 trials of our two highly potent NBD1 stabilizers, SION-719 and SION-451, evaluating the safety, tolerability and pharmacokinetic (“PK”) profile of single and multiple ascending doses in healthy subjects. These trials are randomized (3:1 active:placebo), doubled-blinded, placebo-controlled and are being conducted in Australia. As of January 14, 2025, five single ascending dose (“SAD”) cohorts and three multiple ascending dose (“MAD”) cohorts of SION-719 have been completed, with over 60 healthy subjects dosed, and six SAD cohorts and three MAD cohorts of SION-451 have been completed, with over 70 healthy subjects dosed. Both SION-719 and SION-451 have been generally well tolerated based on interim Phase 1 clinical data as of the data cutoff date of January 14, 2025. We have established target exposure levels for SION-719 and SION-451 to potentially provide clinically meaningful benefit, if administered as part of a dual combination or as an add-on to the current standard of care (“SOC”), based on our preclinical cystic fibrosis human bronchial epithelial (“CFHBE”) model. In these trials, we have achieved the target concentrations for SION-719 and SION-451 with single and multiple doses. We plan to continue enrolling healthy subjects in additional MAD cohorts. We are also developing a portfolio of complementary CFTR modulators designed to work synergistically with our NBD1 stabilizers to improve CFTR function, as seen in preclinical models. In July 2024, we in-licensed three clinical-stage compounds from AbbVie Global Enterprises Ltd. (“AbbVie”) to expand our portfolio of combination product opportunities, including galicaftor (SION-2222), which targets CFTR’s transmembrane domain 1 (“TMD1”), and has completed Phase 2 clinical trials. In addition, we recently completed a Phase 1 clinical trial evaluating SION-109, which targets CFTR’s intracellular loop 4 (“ICL4”) region. We plan to evaluate multiple NBD1 stabilizer candidates and complementary modulator candidates and select the most promising candidates to advance into later-stage development. Initially, we intend to evaluate the lead NBD1 stabilizer candidate in combination with the current standard of care, Trikafta, in a proof-of-concept trial. In parallel, we will determine the proprietary dual combination that we believe is optimal to advance into a later-stage clinical trial in CF patients. We were incorporated under the laws of the State of Delaware in August 2019 under the name Sling Therapeutics, Inc., and changed our name to Sionna Therapeutics, Inc. in July 2021. Our principal executive offices are located at 21 Hickory Drive, Suite 500, Waltham, MA. We have one subsidiary, Sionna Therapeutics Securities Corporation (f/k/a Sling Therapeutics Securities Corporation), formed in 2020 under the laws of the Commonwealth of Massachusetts.

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Compare Stocks

Comparative Price Performance Over Time

Compare Price & Volume

Compare Price Performance

Compare Price & Volume

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Current Analyst Ratings Breakdown

Latest ARVN, SION, AMLX, and HRMY Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest ARVN, SION, AMLX, and HRMY Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

ARVN, SION, AMLX, and HRMY Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

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ARVN, SION, AMLX, and HRMY Company Descriptions

Amylyx Pharmaceuticals NASDAQ:AMLX

Arvinas NASDAQ:ARVN

Harmony Biosciences NASDAQ:HRMY

Sionna Therapeutics NASDAQ:SION

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Latest ARVN, SION, AMLX, and HRMY Earnings

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ARVN, SION, AMLX, and HRMY Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

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ARVN, SION, AMLX, and HRMY Company Descriptions

Amylyx Pharmaceuticals NASDAQ:AMLX

Arvinas NASDAQ:ARVN

Harmony Biosciences NASDAQ:HRMY

Sionna Therapeutics NASDAQ:SION

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